SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_000103 |
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Gene Symbol: | CYP19A1 |
Description: | Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 1, mRNA. |
Gene Location: | chr15(-):51500253-51630795 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.51208422A>T | COSN1678698 | RK165_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-181b-3p |
taaattaTCAGTGAaatgc |
6 |
CUCACUGA | m7b | Disrupted | -0.457000 | -0.130000 |
0.770000 |
|
hsa-miR-27a-3p |
taaattatCTGTGAAatgc |
3 |
UUCACAGU | m7a | Created | -0.076000 | -0.184000 |
-0.380000 |
|
hsa-miR-27b-3p |
taaattatCTGTGAAatgc |
3 |
UUCACAGU | m7a | Created | -0.076000 | -0.184000 |
-0.150000 |
|
hsa-miR-4420 |
taaattaTCAGTGAaatgc |
6 |
GUCACUGA | m7b | Disrupted | -0.503000 | -0.176000 |
0.010000 |
|
hsa-miR-513a-5p |
taaattatCTGTGAAatgc |
3 |
UUCACAGG | m7a | Created | -0.085000 | -0.192000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.51208497G>A | COSN5398394 | RK134_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4765 |
tgcttaaccATCACTCttg |
0 | UGAGUGAU | m7b | (m6b->m7b) | no TS | -0.144000 |
-0.140000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.51208524T>C | COSN8174427 | PCSI_0303_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-148a-5p |
tcttcAGAACTTTgcccca |
0 | AAAGUUCU | m8a | Created | no TS | -0.046000 |
-0.760000 |
|
hsa-miR-148b-5p |
tcttCAGAACTTtgcccca |
0 | AAGUUCUG | m8a | Created | no TS | -0.157000 |
-2.460000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.51209104G>A | COSN7047718 | 8058330 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3924 |
cctgaATACATATgtagtc |
0 | AUAUGUAU | m8a | Created | no TS | 0.041000 | No effect | |
hsa-miR-5580-3p |
cctgaataCATATGTagtc |
0 | CACAUAUG | m7b | Created | no TS | 0.003000 |
0.140000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.51209371G>C | COSN8746299 | AOCS-152-1-X | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1976 |
tccctgaaaGCAGGAGcta |
5 |
CCUCCUGC | m7b | (m7b->m6b) | -0.076000 | no TS |
3.450000 |
|
hsa-miR-29b-1-5p |
tccctgAAACCAGgagcta |
0 | GCUGGUUU | m7b | Created | no TS | 0.060000 | No effect | |
hsa-miR-29b-2-5p |
tccctGAAACCAGgagcta |
5 |
CUGGUUUC | m8a | Created | -0.030000 | 0.019000 | No effect | |
hsa-miR-3160-5p |
tccctGAAAGCaggagcta |
5 |
GGCUUUCU | m6b | Disrupted | 0.069000 | no TS | No effect | |
hsa-miR-370 |
tccctgaaAGCAGGagcta |
5 |
GCCUGCUG | m6b | Disrupted | -0.022000 | no TS |
0.020000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr15:g.51210002G>A | COSN6275179 | RK123_C01 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-373-3p |
tcacatgatGCACTTCaaa |
0 | GAAGUGCU | m7a | (m7a->m6a) | NA | NA |
0.530000 |
hsa-miR-519a-3p |
tcacatgaTGCACTTcaaa |
2 |
AAAGUGCA | m7b | Disrupted | -0.127000 | no TS |
5.250000 |
hsa-miR-519b-3p |
tcacatgaTGCACTTcaaa |
2 |
AAAGUGCA | m7b | Disrupted | -0.127000 | no TS |
5.140000 |
hsa-miR-519c-3p |
tcacatgaTGCACTTcaaa |
2 |
AAAGUGCA | m7b | Disrupted | -0.127000 | no TS |
6.630000 |
hsa-miR-595 |
tcacatgatACACTTCaaa |
0 | GAAGUGUG | m7a | (m6a->m7a) | NA | NA |
-0.090000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
51209885 | rs1050787 | T | T |
hsa-miR-127-5p hsa-miR-181b-3p hsa-miR-3928-5p hsa-miR-4420 hsa-miR-6806-3p |
2 3 2 3 2 |
acAGCTTCAgtga acagctTCAGTGA acAGCTTCAgtga acagctTCAGTGA acAGCTTCAgtga |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.027 -0.041 -0.037 -0.097 -0.034 |
A |
hsa-miR-1183 hsa-miR-1208 hsa-miR-3137 hsa-miR-6760-3p |
2 3 2 3 |
acagCTACAGTga acagctACAGTGA acaGCTACAGtga acagctACAGTGA |
Created Created Created Created |
N N N N |
-0.02 -0.001 -0.155 0.005 |