SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000609
Gene Symbol: CXCL12
Description: Homo sapiens chemokine (C-X-C motif) ligand 12 (CXCL12), transcript variant 2, mRNA.
Gene Location: chr10(-):44865604-44880545
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44370344G>A COSN1489832 RK001_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-380-3p gtttcaATTACATctccca
 0 UAUGUAAU m7b Created no TS -0.081000 No effect
hsa-miR-4708-5p gtttcaattGCATCTCcca
 10
 AGAGAUGC m7b (m7b->m6b) -0.255000 no TS No effect
hsa-miR-380-3p gtttcaATTACATctccca
 0 UAUGUAAU m7b Created no TS -0.081 No effect
hsa-miR-4708-5p gtttcaattGCATCTCcca
 0 AGAGAUGC m7b (m7b->m6b) -0.255 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44370497A>G COSN9209003 AOCS-131-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44370697T>C COSN6971132 8053200 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4773 tagaTGTTCTaagtctttc
 0 CAGAACAG m6b Disrupted -0.041000 -0.036000 No effect
hsa-miR-890 tagatgtTCCAAGTctttc
 0 UACUUGGA m7b Created no TS -0.149000 -0.760000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44371213G>A COSN9209004 AOCS-092-3-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3191-5p aaactgCAGAGAaaattat
 0 CUCUCUGG m6b Created no TS -0.054000 -0.080000
hsa-miR-4446-5p aaactgcAGGGAAAattat
 2
 AUUUCCCU m7b Disrupted -0.126000 -0.061000 7.060000
hsa-miR-4755-5p aaactgcAGGGAAAattat
 2
 UUUCCCUU m7a Disrupted -0.015000 0.019000 No effect
hsa-miR-4768-5p aaactgcAGAGAAaattat
 0 AUUCUCUC m6b Created no TS 0.025000 -1.960000
hsa-miR-5006-3p aaactgcAGGGAAAattat
 2
 UUUCCCUU m7a Disrupted -0.015000 0.019000 0.090000
hsa-miR-670 aaactgCAGGGAaaattat
 3
 GUCCCUGA m6b Disrupted -0.092000 no TS 0.190000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44371828C>A COSN10068061 C0053T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200b-3p tcattCAGTATTAcgaata
 0 UAAUACUG m8a Created no TS 0.092000 -1.250000
hsa-miR-200c-3p tcattCAGTATTAcgaata
 0 UAAUACUG m8a Created no TS 0.092000 -0.470000
hsa-miR-429 tcattCAGTATTAcgaata
 0 UAAUACUG m8a Created no TS 0.060000 -4.650000
hsa-miR-4432 tcattcAGTCTTacgaata
 2
 AAAGACUC m6b Disrupted 0.043000 no TS 5.390000
hsa-miR-4499 tcatTCAGTCTTacgaata
 5
 AAGACUGA m8a Disrupted -0.165000 -0.116000 0.020000
hsa-miR-499a-5p tcattcAGTCTTAcgaata
 2
 UUAAGACU m7b Disrupted 0.039000 no TS 0.140000


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44371834T>C COSN6071915 RK187_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372242C>G COSN5819267 SS6003117 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-5p gtgctCCCTCACatgtcag
 0 GUGAGGGC m7a Disrupted -0.115000 -0.115000 0.030000
hsa-miR-1321 gtgCTCCCTGacatgtcag
 0 CAGGGAGG m7a (m6b->m7a) NA NA No effect
hsa-miR-211-3p gtgcTCCCTGacatgtcag
 5
 GCAGGGAC m6b Created -0.164000 -0.192000 No effect
hsa-miR-3607-5p gtgctcccTCACATGtcag
 1
 GCAUGUGA m7b Disrupted 0.025000 no TS 0.910000
hsa-miR-4270 gtgCTCCCTGAcatgtcag
 5
 UCAGGGAG m8a Created -0.376000 -0.468000 No effect
hsa-miR-4316 gtgctcCCTCACatgtcag
 1
 GGUGAGGC m6b Disrupted -0.037000 no TS 0.020000
hsa-miR-4419a gtgCTCCCTCAcatgtcag
 2
 UGAGGGAG m8a Disrupted -0.160000 -0.031000 No effect
hsa-miR-4441 gtgCTCCCTGacatgtcag
 5
 ACAGGGAG m7b (m6c->m7b) -0.320000 -0.401000 No effect
hsa-miR-4510 gtgCTCCCTCAcatgtcag
 2
 UGAGGGAG m8a Disrupted -0.163000 -0.034000 No effect
hsa-miR-4756-5p gtgCTCCCTGacatgtcag
 0 CAGGGAGG m7a (m6b->m7a) NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372285C>T COSN15450601 AOCS-164-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548q cggtgtGCACCAGggttga
 2
 GCUGGUGC m7b Disrupted -0.070000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372733C>T COSN8640088 1428_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4492 gagtgagacCCAGCCCtca
 0 GGGGCUGG m7b (m7b->m6b) -0.108000 no TS 1.530000
hsa-miR-4498 gagtgagacCCAGCCCtca
 0 UGGGCUGG m7b (m7b->m6b) -0.117000 no TS 0.030000
hsa-miR-4505 gagtgagaCCCAGCCctca
 0 AGGCUGGG m7b Disrupted -0.136000 no TS No effect
hsa-miR-4656 gagtgagacTCAGCCCtca
 1
 UGGGCUGA m7b (m6b->m7b) -0.110000 -0.202000 0.070000
hsa-miR-5001-5p gagtgagacCCAGCCCTca
 0 AGGGCUGG m8a (m8a->m7a) -0.127000 no TS 0.010000
hsa-miR-5589-5p gagtgagACCCAGCCctca
 0 GGCUGGGU m8a Disrupted -0.112000 -0.055000 0.010000
hsa-miR-627 gagtgAGACTCAgccctca
 0 GUGAGUCU m7b Created no TS 0.014000 No effect
hsa-miR-762 gagtgagacCCAGCCCtca
 0 GGGGCUGG m7b (m7b->m6b) -0.108000 no TS 0.210000
hsa-miR-924 gagtgAGACTCagccctca
 0 AGAGUCUU m6b Created -0.038000 -0.068000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372765G>T COSN8640089 J88_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4711-5p ctgagCTGATGCAgcagtg
 0 UGCAUCAG m8a Created -0.016000 -0.168000 -0.020000


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372767G>A COSN14662077 8067509 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372965C>- ICGC_sm132613 RK026_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3675-5p cctgGCCCCATggtcagcc
 0 UAUGGGGC m7b Disrupted -0.398000 -0.299000 No effect
hsa-miR-591 cctggcccCATGGTCagcc
 0 AGACCAUG m7b Disrupted -0.172000 no TS 0.080000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.44372985G>C COSN1489834 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4690-3p gggagacTGGGCTGaggga
 0 GCAGCCCA m7b Disrupted -0.381000 -0.131000 0.090000
hsa-miR-5685 gggagacTGGGCTGaggga
 0 ACAGCCCA m7b Disrupted -0.371000 -0.131000 0.190000
hsa-miR-4690-3p gggagacTGGGCTGaggga
 0 GCAGCCCA m7b Disrupted -0.381 -0.131 0.09
hsa-miR-5685 gggagacTGGGCTGaggga
 0 ACAGCCCA m7b Disrupted -0.371 -0.131 0.19

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
44370496 rs184589176 T T hsa-miR-5584-5p
hsa-miR-6750-5p
hsa-miR-6822-5p
2
2
2
 gaaataTTCCCTA
gaaataTTCCCTA
gaaataTTCCCTA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.088
-0.108
-0.111
C hsa-miR-1321
hsa-miR-3162-5p
hsa-miR-4739
hsa-miR-4756-5p
hsa-miR-496
hsa-miR-6760-5p
2
2
2
2
1
2
 gaaataCTCCCTA
gaaataCTCCCTA
gaaataCTCCCTA
gaaataCTCCCTA
gaAATACTCccta
gaaataCTCCCTA
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.118
-0.227
-0.124
-0.121
-0.068
-0.137
44370969 rs186339497 T T hsa-miR-5095
hsa-miR-655-5p
hsa-miR-7151-3p
3
7
3
 tcCCTGTAAcctc
tccctgTAACCTC
tcCCTGTAAcctc
 Disrupted
Disrupted
Disrupted
N
N
N
 0.013
0.033
0.017
A hsa-miR-211-3p
hsa-miR-3127-5p
hsa-miR-4270
hsa-miR-4441
hsa-miR-6754-5p
2
2
2
2
2
 TCCCTGAaacctc
tCCCTGAAacctc
TCCCTGAaacctc
TCCCTGAaacctc
TCCCTGAaacctc
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.057
-0.041
-0.086
-0.079
-0.08
44371110 rs148728281 G G hsa-miR-204-5p
hsa-miR-211-5p
hsa-miR-4446-5p
hsa-miR-4755-5p
hsa-miR-4780
hsa-miR-5006-3p
hsa-miR-623
hsa-miR-6780b-3p
hsa-miR-6841-3p
2
2
2
2
2
2
2
2
2
 tgcAAGGGAAaag
tgcAAGGGAAaag
tgcaAGGGAAAAg
tgcAAGGGAAAag
tgCAAGGGAaaag
tgcAAGGGAAAag
tgCAAGGGAAaag
tgCAAGGGAaaag
TGCAAGGgaaaag
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.038
-0.038
-0.061
-0.053
-0.104
-0.053
-0.165
-0.098
-0.134
A hsa-miR-4753-3p
hsa-miR-4768-5p
hsa-miR-627-3p
hsa-miR-6809-3p
hsa-miR-6833-3p
2
2
12
2
2
 tgcAAGAGAAaag
tgcaAGAGAAAag
tgcaagAGAAAAG
tgcAAGAGAAAag
tgcaAGAGAAAag
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.027
0.043
0.063
0.067
0.047
44371113 rs143314774 A A hsa-miR-204-5p
hsa-miR-211-5p
hsa-miR-4755-5p
hsa-miR-4780
hsa-miR-5006-3p
hsa-miR-518a-5p
hsa-miR-527
hsa-miR-548aw
hsa-miR-623
hsa-miR-6780b-3p
hsa-miR-6841-3p
2
2
2
2
2
14
14
14
2
2
2
 atttgcAAGGGAA
atttgcAAGGGAA
atttgcAAGGGAA
atttgCAAGGGAa
atttgcAAGGGAA
aTTTGCAAgggaa
aTTTGCAAgggaa
aTTTGCAAgggaa
atttgCAAGGGAA
atttgCAAGGGAa
attTGCAAGGgaa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
N
 -0.038
-0.038
-0.034
-0.104
-0.034
0.046
0.046
0.06
-0.165
-0.098
-0.134
G hsa-miR-4655-3p
hsa-miR-642a-5p
hsa-miR-6803-3p
2
2
2
 atttgCGAGGGAa
atttgcGAGGGAA
atttGCGAGGGAa
 Created
Created
Created
N
N
N
 -0.195
-0.105
-0.453
44371989 rs76300950 G A hsa-miR-1303
hsa-miR-3123
hsa-miR-3925-5p
hsa-miR-4753-3p
hsa-miR-6809-3p
2
2
2
3
4
 tTCTCTAAgagaa
TTCTCTAagagaa
TTCTCTAagagaa
ttctctAAGAGAA
ttctctAAGAGAA
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.013
0.078
0.061
0.096
0.081
G hsa-miR-3919
hsa-miR-4330
hsa-miR-4756-3p
hsa-miR-4768-5p
hsa-miR-6833-3p
hsa-miR-6873-3p
1
2
2
4
4
4
 TTCTCTGAgagaa
ttcTCTGAGAgaa
tTCTCTGAgagaa
ttctctGAGAGAA
ttctctGAGAGAA
ttctctGAGAGAA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.07
0.009
0.033
0.046
0.027
0.048

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