SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001171174
Gene Symbol: CX3CR1
Description: Homo sapiens chemokine (C-X3-C motif) receptor 1 (CX3CR1), transcript variant 2, mRNA.
Gene Location: chr3(-):39304984-39323226
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.39263823A>C COSN7608392 8067211 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-618 catgttTAGAGTTgcaatc
 4
 AAACUCUA m7b Disrupted -0.124000 no TS 5.180000
hsa-miR-891a catgtttagCGTTGCAatc
 0 UGCAACGA m7a (m6a->m7a) no TS -0.235000 -6.920000
hsa-miR-891b catgtttagAGTTGCAatc
 4
 UGCAACUU m7a (m7a->m6a) -0.139000 no TS 5.410000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.39264138C>A COSN7608393 8031681 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-122-5p gagCACTCCAaagtctaca
 0 UGGAGUGU m7a (m6b->m7a) no TS -0.094000 -0.030000
hsa-miR-30b-3p gagcaCTCCCAagtctaca
 5
 CUGGGAGG m6b Disrupted -0.129000 -0.092000 0.130000
hsa-miR-30c-1-3p gagcaCTCCCAagtctaca
 2
 CUGGGAGA m6b Disrupted -0.045000 no TS No effect
hsa-miR-30c-2-3p gagcaCTCCCAagtctaca
 2
 CUGGGAGA m6b Disrupted -0.048000 no TS No effect
hsa-miR-3198 gagcACTCCAaagtctaca
 0 GUGGAGUC m6b Created -0.086000 -0.150000 No effect
hsa-miR-3689a-3p gagcaCTCCCAagtctaca
 5
 CUGGGAGG m6b Disrupted -0.163000 -0.129000 0.010000
hsa-miR-3689b-3p gagcaCTCCCAagtctaca
 5
 CUGGGAGG m6b Disrupted -0.172000 -0.138000 0.040000
hsa-miR-3689c gagcaCTCCCAagtctaca
 5
 CUGGGAGG m6b Disrupted -0.172000 -0.138000 0.040000
hsa-miR-4309 gagcACTCCAaagtctaca
 0 CUGGAGUC m6b Created -0.030000 -0.087000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.39264260C>G COSN5535850 RK124_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4519 cacctggCACTGCTGtgct
 2
 CAGCAGUG m8a Disrupted -0.042000 no TS 1.020000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.39264883T>G COSN15246270 LP6007420-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1261 aaggtgctgTTATCCATgg
 2
 AUGGAUAA m8a (m8a->m7a) 0.001000 no TS No effect
hsa-miR-634 aaggTGCTGGTatccatgg
 0 AACCAGCA m7b Created no TS -0.234000 -4.550000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.39265006G>A COSN6574322 ICGC_MB61 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-379-3p actTTACATAacacagctt
 0 UAUGUAAC m7a (m6b->m7a) no TS 0.014000 -2.270000
hsa-miR-380-3p actTTACATAacacagctt
 0 UAUGUAAU m7a (m6b->m7a) no TS 0.019000 -2.290000
hsa-miR-3924 acttTACATAacacagctt
 0 AUAUGUAU m6b Created -0.240000 -0.229000 -2.170000
hsa-miR-411-3p actTTACATAacacagctt
 0 UAUGUAAC m7a (m6b->m7a) no TS 0.014000 -2.280000
hsa-miR-592 actttacaTGACACAgctt
 2
 UUGUGUCA m7b Disrupted -0.124000 no TS 0.360000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
39263825 rs41481047 A A hsa-miR-520f-5p
hsa-miR-618
5
4
 atgTTTAGAGttg
atgttTAGAGTTg
 Disrupted
Disrupted
N
N
 -0.068
-0.124
C hsa-miR-494-3p
4
 ATGTTTCgagttg
 Created
N
 -0.011

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