SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005214
Gene Symbol:	CTLA4
Description:	Homo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 2, mRNA.
Gene Location:	chr2(+):204732510-204738683
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.203872836C>T			cosmic_v64_1675361				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4517	gaagagagtTCATATTTca	0	AAAUAUGA	m8a	(m7b->m8a)	no TS	-0.137	0.02
hsa-miR-4680-5p	gaagAGAGTTCatatttca	0	AGAACUCU	m7b	Created	no TS	-0.39	-6.83
hsa-miR-5583-3p	gaagagagtCCATATTtca	0	GAAUAUGG	m7b	(m7b->m6c)	-0.156	no TS	1.99

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.203873372A>G			COSN14852701		LP6005334-DNA_C03		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1185-1-3p	tatatataTGTATATatat	18	AUAUACAG	m7a	Created	-0.073000	-0.073000	No effect
hsa-miR-1185-2-3p	tatatataTGTATATatat	18	AUAUACAG	m7a	Created	-0.073000	-0.073000	No effect
hsa-miR-5011-5p	tatatataTATATATAtat	0	UAUAUAUA	m8a	Disrupted	-2.690000	-2.224000	0.320000
hsa-miR-5580-3p	tatatATATGTatatatat	0	CACAUAUG	m6b	Created	no TS	-0.045000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.203873382A>T			COSN6933208		8014741		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1277-5p	tatatATATATTTtaattt	0	AAAUAUAU	m8a	Disrupted	-0.152000	-0.157000	-0.040000
hsa-miR-5011-5p	taTATATATAttttaattt	0	UAUAUAUA	m8a	(m8a->m7a)	-2.690000	-2.606000	-0.180000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.203873791C>A			COSN8608448		3402_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3658	caaTTCTTAAAaacatgtg	1	UUUAAGAA	m8a	Created	-0.132000	-0.285000	-0.450000
hsa-miR-4307	caattcttaAAAACATgtg	0	AAUGUUUU	m7b	(m6c->m7b)	no TS	-0.044000	-3.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.203873872T>G			COSN8608449		1287_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4519	aattaaCACTGCTtgtgtt	3	CAGCAGUG	m7b	Disrupted	-0.255000	no TS	1.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
203873320	rs66857345	-	ATATATACAT	hsa-miR-190a-3p hsa-miR-5011-5p	2 2	taaaggttgtattgcATATATAcatatatat taaaggttgtattgcATATATAcatatatat	Unknown Unknown	N N	-0.276 -0.121
			-
203873328	rs201484258	-	ATATATATATATATATATATATATAT	hsa-miR-190a-3p hsa-miR-3924 hsa-miR-5011-5p	1 1 1	agtgatgctaaaggttgtattgcatatatacATATATAtatatatatatatatatatatatat agtgatgctaaaggttgtattgcatatATACATAtatatatatatatatatatatatatatat agtgatgctaaaggttgtattgcatatatacATATATAtatatatatatatatatatatatat	Unknown Unknown Unknown	N N N	-1.861 No Change -1.52
			-
203873328	rs201801137	-	ATATATATATATATATATATATAT	hsa-miR-190a-3p hsa-miR-3924 hsa-miR-5011-5p	1 1 1	tgatgctaaaggttgtattgcatatatacATATATAtatatatatatatatatatatat tgatgctaaaggttgtattgcatatATACATAtatatatatatatatatatatatatat tgatgctaaaggttgtattgcatatatacATATATAtatatatatatatatatatatat	Unknown Unknown Unknown	N N N	-1.718 No Change -1.402
			-
203873344	rs71971632	-	ATATATATATATATATATAT	hsa-miR-190a-3p hsa-miR-5011-5p	0	catatatacatatatatatATATATAtatatatatatatatatatatatat catatatacatatatataTATATATAtatatatatatatatatatatatat	Unknown Unknown	N N	-1.433 -1.167
			-
203873369	rs59665421	-	T	hsa-miR-190a-3p hsa-miR-5011-5p	0	tATATATAtatat TATATATAtatat	Unknown Unknown	N N	-0.609 -0.568
			C	hsa-miR-3924	0	tatATACATAtat	Unknown	N	-0.164

Genome Browser