SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004369
Gene Symbol:	COL6A3
Description:	Homo sapiens collagen, type VI, alpha 3 (COL6A3), transcript variant 1, mRNA.
Gene Location:	chr2(-):238232654-238322850
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.237324297A>T			COSN1832541		RK015_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1275	cctgCCCCCAatttcccag	0	GUGGGGGA	m6b	Disrupted	-0.192000	no TS	10.490000
hsa-miR-4278	cctgCCCCCTAtttcccag	0	CUAGGGGG	m7b	Created	no TS	-0.235000	-4.690000
hsa-miR-4488	cctGCCCCCTatttcccag	0	AGGGGGCG	m7a	(m6b->m7a)	-0.236000	no TS	-0.040000
hsa-miR-4665-5p	cctgCCCCCAatttcccag	0	CUGGGGGA	m6b	Disrupted	-0.199000	no TS	2.630000
hsa-miR-4697-5p	cctGCCCCCTatttcccag	0	AGGGGGCG	m7a	(m6b->m7a)	-0.239000	no TS	-0.040000
hsa-miR-4716-3p	cctgCCCCCTatttcccag	0	AAGGGGGA	m6b	Created	no TS	-0.216000	-5.000000
hsa-miR-1275	cctgCCCCCAatttcccag	0	GUGGGGGA	m6b	Disrupted	-0.192	no TS	10.49
hsa-miR-4278	cctgCCCCCTAtttcccag	0	CUAGGGGG	m7b	Created	no TS	-0.235	-4.69
hsa-miR-4488	cctGCCCCCTatttcccag	0	AGGGGGCG	m7a	(m6b->m7a)	-0.236	no TS	-0.04
hsa-miR-4665-5p	cctgCCCCCAatttcccag	0	CUGGGGGA	m6b	Disrupted	-0.199	no TS	2.63
hsa-miR-4697-5p	cctGCCCCCTatttcccag	0	AGGGGGCG	m7a	(m6b->m7a)	-0.239	no TS	-0.04
hsa-miR-4716-3p	cctgCCCCCTatttcccag	0	AAGGGGGA	m6b	Created	no TS	-0.216	-5

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.237324559C>G			COSN7241178		8014573		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-146a-5p	ggcAGTTCTCtcgaatact	2	UGAGAACU	m7b	(m7b->m6c)	-0.075000	no TS	1.510000
hsa-miR-146b-5p	ggcAGTTCTCtcgaatact	2	UGAGAACU	m7b	(m7b->m6c)	-0.075000	no TS	1.510000
hsa-miR-196b-3p	ggcagttCTGTCGAatact	0	UCGACAGC	m7a	Created	no TS	-0.224000	-6.470000
hsa-miR-3925-5p	ggcaGTTCTCTcgaatact	2	AAGAGAAC	m7b	Disrupted	-0.131000	no TS	2.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.237324645C>G			COSN8991010		AOCS-108-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4740-3p	acactcgaaCTCGGGaggg	5	GCCCGAGA	m6b	Disrupted	-0.208000	no TS	0.330000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
237324303	rs71777598	-	CTG	hsa-miR-1207-5p hsa-miR-1237-5p hsa-miR-4488 hsa-miR-4697-5p hsa-miR-4763-3p hsa-miR-486-3p hsa-miR-6721-5p hsa-miR-6846-5p hsa-miR-6848-5p	2 2 2 2 2 2 2 2 2	cattCCCTGCCcccaat cattccctGCCCCCAat cattccctGCCCCCAat cattccctGCCCCCAat cattCCCTGCCcccaat cattccCTGCCCCcaat cattcCCTGCCCccaat cattccctGCCCCCAat cattccctGCCCCCAat	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N	-0.246 -0.246 -0.236 -0.239 -0.237 -0.206 -0.203 -0.231 -0.234
			-	hsa-miR-1275 hsa-miR-328-5p hsa-miR-4665-5p hsa-miR-625-5p hsa-miR-6751-5p hsa-miR-6795-5p hsa-miR-6803-5p hsa-miR-6885-5p hsa-miR-6887-5p hsa-miR-7109-5p	2 2 2 2 2 2 2 2 2 2	cattccCCCCCAAt cattcCCCCCCAat cattccCCCCCAAt caTTCCCCCccaat cattccCCCCCAAt catTCCCCCCcaat cattccCCCCCAAt cattcCCCCCCAat catTCCCCCCcaat cattcCCCCCCAAt	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N	-0.004 -0.266 -0.004 -0.218 -0.004 -0.638 0.006 -0.273 -0.612 -0.292

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