SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000088
Gene Symbol:	COL1A1
Description:	Homo sapiens collagen, type I, alpha 1 (COL1A1), mRNA.
Gene Location:	chr17(-):48261456-48279000
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.50184475G>T			COSN8603362		J17_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3613-3p	tttTTTTTTGTggatgggg	0	ACAAAAAA	m8a	Disrupted	0.161000	0.158000	0.590000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.50184643C>T			COSN8838177		AOCS-055-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2115-5p	gggTGGAAGCggctcccca	11	AGCUUCCA	m7b	(m7b->m6c)	-0.154000	-0.143000	0.010000
hsa-miR-505-5p	gggtggaagTGGCTCCCca	10	GGGAGCCA	m8a	(m7a->m8a)	-0.276000	-0.393000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.50184767A>C			COSN5179345		PD3945a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3173-5p	ttgtgccGCAGGGCtgggc	4	UGCCCUGC	m7b	Disrupted	-0.071000	no TS	0.720000
hsa-miR-3940-3p	ttgtgccgCCGGGCTGggc	0	CAGCCCGG	m8a	Created	no TS	-0.131000	-6.480000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
50184194	rs12944834	A	A	hsa-miR-2115-5p hsa-miR-3977 hsa-miR-516a-3p hsa-miR-516b-3p hsa-miR-6885-3p hsa-miR-7162-5p	11 11 11 11 3 11	GGAAGCAaaagac gGAAGCAAaagac GGAAGCAaaagac GGAAGCAaaagac ggAAGCAAAAgac GGAAGCAaaagac	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.143 -0.108 -0.184 -0.184 -0.163 -0.183
			G	hsa-miR-4790-5p hsa-miR-6830-3p	3 14	ggAAGCGAAagac ggaagcGAAAGAC	Created Created	N N	-0.18 -0.138
50184475	rs200882287	G	G	hsa-miR-3613-3p	3	TTTTTTGtggatg	Disrupted	N	0.003
50184476	rs58879635	-	TT	hsa-miR-3613-3p	3	ttTTTTTTGtggatg	Unknown	N	-0.001
			-
50185481	rs201085309	G	G	hsa-miR-505-5p hsa-miR-6827-5p	10 11	aaccTGGCTCCct aacctGGCTCCCt	Disrupted Disrupted	N N	-0.165 -0.267
			C	hsa-miR-1321 hsa-miR-1827 hsa-miR-3612 hsa-miR-4736 hsa-miR-4739 hsa-miR-4756-5p hsa-miR-650 hsa-miR-657 hsa-miR-6808-5p hsa-miR-6893-5p hsa-miR-940	11 9 10 7 11 11 10 7 7 7 7	aacctgCCTCCCT aacCTGCCTCcct aaccTGCCTCCct aACCTGCCtccct aacctgCCTCCCT aacctgCCTCCCT aaccTGCCTCCct AACCTGCctccct aaCCTGCCTccct aaCCTGCCTccct aaCCTGCCTccct	Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N	-0.128 -0.129 -0.155 -0.206 -0.138 -0.11 -0.136 -0.086 -0.205 -0.186 -0.13
50185482	rs199806909	G	G	hsa-miR-505-5p hsa-miR-6827-5p	10 11	caaccTGGCTCCc caacctGGCTCCC	Disrupted Disrupted	N N	-0.165 -0.267
			A	hsa-miR-4300 hsa-miR-4633-3p hsa-miR-5591-5p hsa-miR-6500-5p hsa-miR-6726-5p hsa-miR-920	11 10 11 10 11 11	caacctAGCTCCC caaccTAGCTCCc caacctAGCTCCC caaccTAGCTCCc caacctAGCTCCC caacctAGCTCCC	Created Created Created Created Created Created	N N N N N N	-0.197 -0.135 -0.234 -0.117 -0.215 -0.197

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