SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_017738
Gene Symbol:	CNTLN
Description:	Homo sapiens centlein, centrosomal protein (CNTLN), transcript variant 2, mRNA.
Gene Location:	chr9(+):17135037-17503917
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.17502882C>T			COSN8520376		J30_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-338-5p	caaATATTGTcacaaatca	0	AACAAUAU	m7b	(m6b->m7b)	no TS	-0.090000	-6.620000
hsa-miR-3688-5p	caaataTTGCCACaaatca	10	AGUGGCAA	m7b	Disrupted	-0.460000	no TS	1.950000
hsa-miR-4474-3p	caaatattGCCACAAatca	10	UUGUGGCU	m7a	Disrupted	-0.198000	no TS	0.540000
hsa-miR-4504	caaataTTGTCACAaatca	0	UGUGACAA	m8a	Created	no TS	-0.365000	-5.420000
hsa-miR-542-3p	caaatatTGTCACAaatca	0	UGUGACAG	m7a	Created	no TS	-0.145000	-0.310000
hsa-miR-758	caaatattGTCACAAAtca	0	UUUGUGAC	m8a	Created	no TS	-0.337000	-3.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.17503127A>G			COSN2314342		RK016_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-574-3p	aactTGAGCGTttattgaa	0	CACGCUCA	m7b	Created	no TS	-0.320000	-5.460000
hsa-miR-574-3p	aactTGAGCGTttattgaa	0	CACGCUCA	m7b	Created	no TS	-0.32	-5.46

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.17503465C>T			COSN7560889		8047838		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1303	tttttggttTCTCTAAttc	0	UUUAGAGA	m7b	(m6c->m7b)	no TS	-0.076000	-0.210000
hsa-miR-3123	tttttggtTTCTCTaattc	3	CAGAGAAU	m6b	Created	-0.009000	-0.032000	-0.060000
hsa-miR-3125	tttttggTTCCTCTAattc	3	UAGAGGAA	m8a	Disrupted	-0.177000	no TS	2.730000
hsa-miR-3914	tttttGGTTCCTctaattc	4	AAGGAACC	m7b	Disrupted	-0.228000	no TS	0.570000
hsa-miR-3916	tttttggTTCCTCTaattc	3	AAGAGGAA	m7b	Disrupted	-0.177000	no TS	1.810000
hsa-miR-3925-5p	tttttggtTTCTCTaattc	0	AAGAGAAC	m6b	Created	no TS	-0.034000	-0.140000
hsa-miR-3928	tttttgGTTCCTCtaattc	2	GGAGGAAC	m7b	Disrupted	-0.347000	-0.200000	2.840000
hsa-miR-877-5p	tttttggtTCCTCTAattc	3	GUAGAGGA	m7b	Disrupted	-0.284000	no TS	0.330000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
17502887	rs147405918	A	A	hsa-miR-29a-5p hsa-miR-4474-3p hsa-miR-7108-5p	1 10 10	gccacAAATCAGt GCCACAAatcagt GCCACAAatcagt	Disrupted Disrupted Disrupted	N N N	-0.075 -0.198 -0.19
			C	hsa-miR-147a hsa-miR-3911 hsa-miR-644a	11 11 10	gCCACACAtcagt gCCACACAtcagt GCCACACAtcagt	Created Created Created	N N N	-0.198 -0.167 -0.49

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