SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015226
Gene Symbol:	CLEC16A
Description:	Homo sapiens C-type lectin domain family 16, member A (CLEC16A), transcript variant 2, mRNA.
Gene Location:	chr16(+):11038344-11276046
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.11179153G>A			COSN8484933		AOCS-092-3-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3614-5p	ttggcagCAAGTGaacatt	0	CCACUUGG	m6b	Created	no TS	-0.089000	No effect
hsa-miR-3622a-3p	ttggcagCAGGTGAacatt	2	UCACCUGA	m7a	Disrupted	-0.227000	-0.082000	0.020000
hsa-miR-3622b-3p	ttggcagCAGGTGAacatt	2	UCACCUGA	m7a	Disrupted	-0.220000	-0.082000	No effect
hsa-miR-370	ttggCAGCAGGtgaacatt	0	GCCUGCUG	m7b	Disrupted	-0.222000	-0.023000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.11179440G>C			COSN8484934		AOCS-142-3-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4251	taTTCTCAGGtacacacag	8	CCUGAGAA	m8a	(m8a->m7a)	-0.057000	-0.057000	No effect
hsa-miR-4324	tatTCTCAGGtacacacag	2	CCCUGAGA	m7b	(m7b->m6b)	-0.090000	0.055000	No effect
hsa-miR-4663	tattCTCAGCTacacacag	0	AGCUGAGC	m7a	Created	NA	NA	No effect
hsa-miR-544b	tattCTCAGGTacacacag	4	ACCUGAGG	m7a	Disrupted	0.004000	0.004000	0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.11179642G>A			COSN8484935		AOCS-004-1-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4746-5p	gaaccagttGGGACCGtga	3	CCGGUCCC	m7b	(m7b->m6c)	-0.527000	-0.282000	0.030000
hsa-miR-582-3p	gaACCAGTTAggaccgtga	0	UAACUGGU	m8a	(m7a->m8a)	0.002000	-0.072000	-2.940000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.11179869C>T			COSN6079552		RK119_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-455-3p	ttccccattTGGACTGggt	0	GCAGUCCA	m7b	(m6c->m7b)	no TS	-0.039000	-0.750000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.11181683C>T			COSN6079553		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
11178931	rs200938700	A	A	hsa-miR-20a-3p hsa-miR-452-3p	2 4	ATGCAGAtgactg atgCAGATGActg	Disrupted Disrupted	N N	-0.127 -0.022
			G	hsa-miR-3622a-3p hsa-miR-3622b-3p hsa-miR-4704-3p hsa-miR-6765-3p	4 4 2 4	atgCAGGTGActg atgCAGGTGActg atgcagGTGACTG atgCAGGTGActg	Created Created Created Created	N N N N	-0.088 -0.095 -0.043 -0.088
11179548	rs78736578	C	C	hsa-miR-1200 hsa-miR-1238-5p hsa-miR-1296-3p hsa-miR-4324 hsa-miR-4481 hsa-miR-4745-5p hsa-miR-4758-5p hsa-miR-491-5p hsa-miR-544b	4 3 3 4 3 3 3 3 4	tccccaCTCAGGA tccCCACTCAgga tCCCCACTcagga tccccaCTCAGGA tcCCCACTCAgga tcCCCACTCAgga tccCCACTCAgga TCCCCACtcagga tccccaCTCAGGA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.042 -0.014 -0.1 0.001 -0.185 -0.164 -0.014 -0.063 0.004
			A	hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-450a-2-3p hsa-miR-509-3p hsa-miR-6763-5p hsa-miR-6810-5p hsa-miR-6857-5p	3 3 3 3 3 3 3	TCCCCAAtcagga TCCCCAAtcagga TCCCCAAtcagga tccCCAATCAgga TCCCCAAtcagga TCCCCAAtcagga TCCCCAAtcagga	Created Created Created Created Created Created Created	N N N N N N N	-0.063 -0.118 -0.05 -0.025 -0.121 -0.072 -0.077
11179869	rs143141534	C
			T	hsa-miR-455-3p	0	cccattTGGACTG	Created	N	-0.039
11179947	rs201992232	G	G	hsa-miR-4740-3p	0	cagCTCGGGAgcc	Disrupted	N	-0.062
			A	hsa-miR-1200 hsa-miR-3160-3p hsa-miR-4324 hsa-miR-4487 hsa-miR-544b hsa-miR-558	0	cagCTCAGGAgcc CAGCTCAggagcc cagCTCAGGAgcc CAGCTCAggagcc cagCTCAGGAgcc CAGCTCAggagcc	Created Created Created Created Created Created	N N N N N N	0.085 0.007 0.041 -0.066 0.044 0.027
11181004	rs199749058	T	T	hsa-miR-1236-5p hsa-miR-4324 hsa-miR-4693-3p hsa-miR-5586-3p hsa-miR-6761-5p	1 2 1 1 2	gGTCACTCtcagg ggtcacTCTCAGG ggtCACTCTCAgg ggTCACTCTcagg ggtcaCTCTCAGg	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	0.039 0.054 -0.02 0.079 0.067
			A	hsa-miR-3659 hsa-miR-4658 hsa-miR-574-5p hsa-miR-6790-5p hsa-miR-6808-3p hsa-miR-7973	1 1 1 1 1 1	ggtcACACTCAgg ggtcACACTCAgg ggtCACACTCAgg ggtcACACTCAgg GGTCACActcagg GGTCACActcagg	Created Created Created Created Created Created	N N N N N N	0.036 0.055 -0.014 0.093 0.019 -0.075
11181789	rs200756753	G	G	hsa-miR-1913 hsa-miR-324-3p hsa-miR-3622a-3p hsa-miR-3622b-3p hsa-miR-412-3p hsa-miR-6754-3p hsa-miR-6765-3p	2 2 3 3 3 3 3	GGGGCAGgtgaag GGGGCAGgtgaag ggggCAGGTGAag ggggCAGGTGAag ggggcaGGTGAAG ggggcaGGTGAAG ggggCAGGTGAag	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.238 -0.238 -0.082 -0.082 -0.187 -0.187 -0.072
			A	hsa-miR-3614-5p hsa-miR-6500-3p hsa-miR-6837-3p	3 3 3	ggggCAAGTGAag ggggCAAGTGAag ggggcaAGTGAAG	Created Created Created	N N N	-0.029 -0.027 -0.125
11182051	rs201946429	G	G	hsa-miR-4281 hsa-miR-4740-3p hsa-miR-4746-5p	4 3 3	agcctCGGGACCg agcCTCGGGAccg agcctcGGGACCG	Disrupted Disrupted Disrupted	N N N	-0.234 -0.174 -0.282
			A	hsa-miR-1200 hsa-miR-2467-5p hsa-miR-3188 hsa-miR-3975 hsa-miR-4324 hsa-miR-4649-3p hsa-miR-485-5p hsa-miR-544b hsa-miR-6884-5p	3 2 2 2 3 3 2 3 2	agcCTCAGGAccg AGCCTCAggaccg AGCCTCAggaccg AGCCTCAggaccg agcCTCAGGAccg aGCCTCAGgaccg AGCCTCAggaccg agCCTCAGGAccg AGCCTCAggaccg	Created Created Created Created Created Created Created Created Created	N N N N N N N N N	-0.073 -0.203 -0.127 -0.132 -0.077 -0.154 -0.098 -0.326 -0.101
11182056	rs2040	C	C	hsa-miR-4281 hsa-miR-4746-5p	4 3	CGGGACCgctcta cGGGACCGctcta	Disrupted Disrupted	N N	-0.234 -0.282
			T	hsa-miR-2278 hsa-miR-4274	2 2	cgggaCTGCTCTA cggGACTGCTcta	Created Created	N N	-0.265 -0.122

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