| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
||||||||
| Home | Search | Help | Download | |||||
| RefSeq ID: | NM_000750 |
|---|---|
| Gene Symbol: | CHRNB4 |
| Description: | Homo sapiens cholinergic receptor, nicotinic, beta 4 (CHRNB4), mRNA. |
| Gene Location: | chr15(-):78916635-78933587 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.78624356C>A | COSN1180638 | HCC90T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4493 |
ctgagaGGCCTTCcctaac |
6 |
AGAAGGCC | m7b | Disrupted | -0.453000 | -0.227000 |
5.160000 |
|
| hsa-miR-4747-5p |
ctgagaggCCTTCCCTaac |
6 |
AGGGAAGG | m8a | Disrupted | -0.640000 | -0.480000 | No effect | |
| hsa-miR-4757-5p |
ctgAGAGGCCTtccctaac |
7 |
AGGCCUCU | m8a | Disrupted | -0.202000 | no TS |
5.840000 |
|
| hsa-miR-5196-5p |
ctgagaggCCTTCCCTaac |
6 |
AGGGAAGG | m8a | Disrupted | -0.709000 | -0.512000 | No effect | |
| hsa-miR-4493 |
ctgagaGGCCTTCcctaac |
6 |
AGAAGGCC | m7b | Disrupted | -0.453000 | -0.227000 |
5.160000 |
|
| hsa-miR-4747-5p |
ctgagaggCCTTCCCTaac |
6 |
AGGGAAGG | m8a | Disrupted | -0.640000 | -0.480000 | No effect | |
| hsa-miR-4757-5p |
ctgAGAGGCCTtccctaac |
7 |
AGGCCUCU | m8a | Disrupted | -0.202000 | no TS |
5.840000 |
|
| hsa-miR-5196-5p |
ctgagaggCCTTCCCTaac |
6 |
AGGGAAGG | m8a | Disrupted | -0.709000 | -0.512000 | No effect | |
| hsa-miR-4493 |
ctgagaGGCCTTCcctaac |
0 | AGAAGGCC | m7b | Disrupted | -0.453 | -0.227 |
5.16 |
|
| hsa-miR-4747-5p |
ctgagaggCCTTCCCTaac |
0 | AGGGAAGG | m8a | Disrupted | -0.64 | -0.48 | No effect | |
| hsa-miR-4757-5p |
ctgAGAGGCCTtccctaac |
0 | AGGCCUCU | m8a | Disrupted | -0.202 | no TS |
5.84 |
|
| hsa-miR-5196-5p |
ctgagaggCCTTCCCTaac |
0 | AGGGAAGG | m8a | Disrupted | -0.709 | -0.512 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.78624383G>A | COSN5401160 | RK172_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-186-5p |
ccATTCTTTGctccaatgt |
1 |
CAAAGAAU | m8a | (m8a->m7b) | 0.062000 | -0.010000 | No effect | |
| hsa-miR-3198 |
ccattctttACTCCAatgt |
0 | GUGGAGUC | m6b | Created | no TS | -0.159000 |
-5.780000 |
|
| hsa-miR-4309 |
ccattctttACTCCAatgt |
0 | CUGGAGUC | m6b | Created | no TS | -0.149000 |
-0.700000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.78624514A>G | ICGC_8A8D4AE4-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4530 |
caaagTGCTGGGattacaa |
0 | CCCAGCAG | m7a | Created | NA | NA |
-7.8 |
|
| hsa-miR-4733-5p |
caaagtgcTGGGATTacaa |
0 | AAUCCCAA | m7a | Created | NA | NA |
-0.85 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.78624754C>G | COSN7249436 | 8066491 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4795-5p |
cacaCACTTCTagattctt |
2 |
AGAAGUGG | m7a | Disrupted | -0.108000 | -0.108000 |
0.690000 |
|
| hsa-miR-595 |
caCACACTTCtagattctt |
4 |
GAAGUGUG | m8a | (m8a->m7b) | -0.111000 | -0.111000 |
0.350000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.78625008A>C | COSN14654357 | TCGA-HC-8264-01 | [prostate][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-29b-1-5p |
ccccatcAAACCAGCcaca |
4 |
GCUGGUUU | m8a | Disrupted | -0.082000 | no TS |
-1.470000 |
|
| hsa-miR-3940-5p |
ccccatCAACCCAgccaca |
0 | GUGGGUUG | m7b | Created | no TS | -0.176000 | No effect | |
| hsa-miR-4505 |
ccccatcaaCCCAGCCaca |
6 |
AGGCUGGG | m7b | (m6b->m7b) | -0.138000 | -0.420000 | No effect | |
| hsa-miR-4507 |
ccccatCAACCCAGccaca |
0 | CUGGGUUG | m8a | Created | no TS | -0.185000 | No effect | |
| hsa-miR-5087 |
ccccatCAAACCagccaca |
4 |
GGGUUUGU | m6b | Disrupted | -0.066000 | no TS |
5.620000 |
|
| hsa-miR-5589-5p |
ccccatcaACCCAGCCaca |
0 | GGCUGGGU | m8a | Created | no TS | -0.184000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr15:g.78625018A>C | COSN8478811 | AOCS-139-6-3 | [ovary][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-193b-5p |
tggccatcAACCCCatcaa |
5 |
CGGGGUUU | m6b | Disrupted | -0.167000 | no TS |
7.120000 |
| hsa-miR-3170 |
tggccatcAACCCCAtcaa |
5 |
CUGGGGUU | m7b | Disrupted | -0.175000 | no TS |
0.750000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 78625005 | rs143826466 | - | - |
hsa-miR-29b-1-5p hsa-miR-3652 hsa-miR-4430 hsa-miR-4474-3p hsa-miR-5087 hsa-miR-6842-3p |
4 6 6 3 4 6 |
cAAACCAGccaca caaaCCAGCCAca caaaCCAGCCAca caaaccAGCCACA CAAACCAgccaca caaaCCAGCCAca |
Unknown Unknown Unknown Unknown Unknown Unknown |
N N N N N N |
-0.082 0.008 0.004 -0.012 -0.066 -0.048 |
| C |
hsa-miR-4505 hsa-miR-5589-5p hsa-miR-5787 hsa-miR-629-5p hsa-miR-6839-3p |
4 4 4 4 4 |
caaaCCCAGCCAca caaACCCAGCcaca caaaCCCAGCCAca cAAACCCAgccaca cAAACCCAgccaca |
Unknown Unknown Unknown Unknown Unknown |
N N N N N |
-0.292 -0.2 -0.32 -0.089 -0.058 |