| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001190455 |
|---|---|
| Gene Symbol: | CHRNA7 |
| Description: | Homo sapiens cholinergic receptor, nicotinic, alpha 7 (CHRNA7), transcript variant 1, mRNA. |
| Gene Location: | chr15(+):32322690-32462384 |
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| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32168959A>G | COSN15020419 | LP6005409-DNA_A02 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-183-3p |
ttttctgcAATTCAacttt |
1 |
GUGAAUUA | m6b | Disrupted | 0.013000 | 0.019000 |
0.420000 |
|
| hsa-miR-219-2-3p |
ttttctgCAATTCaacttt |
4 |
AGAAUUGU | m6b | Disrupted | -0.063000 | no TS | No effect | |
| hsa-miR-2964a-3p |
ttttctGCAATTCaacttt |
3 |
AGAAUUGC | m7b | Disrupted | -0.331000 | -0.060000 |
0.290000 |
|
| hsa-miR-3158-5p |
tttTCTGCAGttcaacttt |
2 |
CCUGCAGA | m7b | (m6b->m7b) | -0.218000 | -0.474000 |
-2.920000 |
|
| hsa-miR-3545-3p |
ttttctgCAGTTCAActtt |
0 | UUGAACUG | m8a | Created | no TS | -0.258000 |
-7.670000 |
|
| hsa-miR-4418 |
ttttCTGCAGTtcaacttt |
0 | CACUGCAG | m7b | Created | no TS | -0.250000 |
-10.280000 |
|
| hsa-miR-509-3-5p |
ttttCTGCAGTtcaacttt |
0 | UACUGCAG | m7b | Created | no TS | -0.231000 |
-2.940000 |
|
| hsa-miR-509-5p |
ttttCTGCAGTtcaacttt |
0 | UACUGCAG | m7b | Created | no TS | -0.231000 |
-2.370000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr15:g.32169132C>A | COSN8589784 | J30_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-204-5p |
tcAAAGGGAAgcaggtttc |
2 |
UUCCCUUU | m8a | (m7a->m8a) | -0.043000 | -0.134000 |
-0.280000 |
| hsa-miR-211-5p |
tcAAAGGGAAgcaggtttc |
2 |
UUCCCUUU | m8a | (m7a->m8a) | -0.052000 | -0.145000 |
-0.280000 |
| hsa-miR-2115-5p |
tcaaagGGAAGCaggtttc |
0 | AGCUUCCA | m6b | Created | no TS | -0.105000 |
-12.470000 |
| hsa-miR-3193 |
tcaaagggACGCAGGtttc |
0 | UCCUGCGU | m7b | Disrupted | -0.222000 | no TS |
5.940000 |
| hsa-miR-4755-5p |
tcaAAGGGAAgcaggtttc |
0 | UUUCCCUU | m7b | (m6b->m7b) | no TS | -0.064000 |
-0.480000 |
| hsa-miR-5006-3p |
tcaAAGGGAAgcaggtttc |
0 | UUUCCCUU | m7b | (m6b->m7b) | no TS | -0.083000 |
-0.030000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 32168959 | rs199564975 | A | A |
hsa-miR-1273h-3p hsa-miR-183-3p hsa-miR-219a-2-3p hsa-miR-219b-3p hsa-miR-3678-3p hsa-miR-4452 |
5 1 4 3 5 1 |
TCTGCAAttcaac tctgcAATTCAAc tctgCAATTCAac tctGCAATTCAac TCTGCAAttcaac tctgcAATTCAAc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.138 -0.006 -0.063 -0.271 -0.128 -0.008 |
| G |
hsa-miR-203b-3p hsa-miR-3158-5p hsa-miR-4418 hsa-miR-509-3-5p hsa-miR-509-5p hsa-miR-7158-3p |
1 5 5 5 5 1 |
tctgCAGTTCAAc TCTGCAGttcaac tCTGCAGTtcaac tCTGCAGTtcaac tCTGCAGTtcaac tctgcAGTTCAAc |
Created Created Created Created Created Created |
N N N N N N |
-0.258 -0.256 -0.25 -0.231 -0.231 -0.066 |