SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000745
Gene Symbol: CHRNA5
Description: Homo sapiens cholinergic receptor, nicotinic, alpha 5 (CHRNA5), mRNA.
Gene Location: chr15(+):78857861-78887611
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.78593399G>A COSN8176887 ASHPC_0017_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1246 ttaacagatAATCCATTtg
 0 AAUGGAUU m8a (m7b->m8a) no TS -0.187000 -1.730000
hsa-miR-452-3p ttaaCAGATGAtccatttg
 0 CUCAUCUG m7b Disrupted -0.205000 no TS 0.530000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78594416T>C ICGC_8A8D2172-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125a-3p tggctcaCACCTGTaatcc
 0 ACAGGUGA m7a Created -0.164 -0.164 No effect
hsa-miR-3934 tggctcACACCTGtaatcc
 0 UCAGGUGU m7b Created -0.188 -0.269 No effect
hsa-miR-552 tggctcaCACCTGTaatcc
 0 AACAGGUG m7b Created -0.503 -0.636 No effect
hsa-miR-5683 tggctcaCATCTGTAatcc
 2
 UACAGAUG m8a Disrupted -0.069 no TS No effect
hsa-miR-576-3p tggctCACATCTgtaatcc
 2
 AAGAUGUG m7b Disrupted -0.021 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78594426A>C ICGC_8A8D2636-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p ctgtaaTCCCAGCactttg
 0 GCUGGGAA m7a Created NA NA -0.4
hsa-miR-5004-3p ctgtAATCCAAGcactttg
 2
 CUUGGAUU m8a Disrupted 0.026 no TS 1.13
hsa-miR-5089 ctgtAATCCCAgcactttg
 0 GUGGGAUU m7b Created -0.049 -0.05 No effect
hsa-miR-512-3p ctgtaatccCAGCACTTtg
 0 AAGUGCUG m8a (m7b->m8a) -0.066 -0.086 3.26
hsa-miR-520f ctgtaatccAAGCACTTtg
 0 AAGUGCUU m8a (m8a->m7b) -0.03 no TS 2.55
hsa-miR-5589-5p ctgtaatCCCAGCactttg
 0 GGCUGGGU m6b Created -0.119 -0.208 -2.86
hsa-miR-636 ctgtaatcCAAGCACtttg
 0 UGUGCUUG m7b Disrupted -0.022 no TS 7.47

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78594501G>A ICGC_C88EB896-2A78-11E2-BDED-1EFD496BB9B8 CPCG_0103_Pr_P_P4 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-193b-5p catggtgAAACCCCGtctc
 0 CGGGGUUU m8a Created -0.193 -0.235 No effect
hsa-miR-412 catGGTGAAGccccgtctc
 2
 ACUUCACC m7b (m7b->m6b) -0.078 no TS -0.74
hsa-miR-4508 catggtgaAGCCCCGtctc
 0 GCGGGGCU m7b Disrupted -0.215 no TS No effect
hsa-miR-5096 catGGTGAAACcccgtctc
 0 GUUUCACC m8a Created -0.06 -0.201 -1.25

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78594572A>G ICGC_8A8D2C58-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1200 agctaCTCAGGAGgctgag
 0 CUCCUGAG m8a Created no TS -0.066 -0.16
hsa-miR-2682-3p agctactcAAGAGGCtgag
 0 CGCCUCUU m7b Disrupted -0.086 no TS 1.97
hsa-miR-4324 agctaCTCAGGaggctgag
 0 CCCUGAGA m6b Created no TS -0.022 6.93
hsa-miR-526b-5p agctaCTCAAGAGgctgag
 2
 CUCUUGAG m8a Disrupted -0.024 no TS 0.94
hsa-miR-544b agctaCTCAGGaggctgag
 0 ACCUGAGG m6b Created no TS -0.013 No effect
hsa-miR-660-3p agctactCAGGAGGctgag
 0 ACCUCCUG m7b Created no TS -0.097 -6.97

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78594765T>C COSN5756803 HX28T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-194-5p acaCTGTTACAtacctgta
 6
 UGUAACAG m8a Created -0.248000 -0.489000 -0.120000
hsa-miR-379-3p acactGTTACATAcctgta
 0 UAUGUAAC m8a Created no TS -0.140000 -0.360000
hsa-miR-410 acactGTTATATacctgta
 3
 AAUAUAAC m7b Disrupted -0.081000 -0.041000 -0.340000
hsa-miR-411-3p acactGTTACATAcctgta
 0 UAUGUAAC m8a Created no TS -0.140000 -1.510000
hsa-miR-4495 acactgTTACATacctgta
 0 AAUGUAAA m6b Created no TS 0.025000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.78595096T>G COSN6642913 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
78593545 rs199612620 C C hsa-miR-3691-5p
hsa-miR-376b-5p
hsa-miR-376c-5p
hsa-miR-4318
hsa-miR-4693-5p
hsa-miR-4752
hsa-miR-7114-5p
hsa-miR-8056
hsa-miR-892a
2
2
2
2
2
2
2
2
2
 aATCCACAgtaaa
aATCCACAgtaaa
aATCCACAgtaaa
aatCCACAGTAaa
aatcCACAGTAAa
aATCCACAgtaaa
aaTCCACAGtaaa
AATCCACAgtaaa
aatcCACAGTAaa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.15
-0.16
-0.16
-0.428
-0.29
-0.234
-0.259
-0.37
-0.14
T hsa-miR-1246
2
 AATCCATAgtaaa
 Created
N
 -0.304
78593870 rs200751877 G G hsa-miR-483-5p
2
 aacCCCGTCTcta
 Disrupted
N
 -0.177
A hsa-miR-1273f
hsa-miR-193b-5p
hsa-miR-3170
hsa-miR-6855-5p
hsa-miR-6890-5p
2
2
2
2
2
 aaccCCATCTCta
AACCCCAtctcta
AACCCCAtctcta
AACCCCAtctcta
aACCCCATctcta
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.108
-0.127
-0.148
-0.139
-0.175
78594506 rs55989223 G G hsa-miR-4508
hsa-miR-483-5p
2
2
 AGCCCCGtctcta
agcCCCGTCTcta
 Disrupted
Disrupted
N
N
 -0.215
-0.134
A hsa-miR-1273f
hsa-miR-185-3p
hsa-miR-3675-5p
hsa-miR-4283
hsa-miR-4489
2
2
2
2
2
 agccCCATCTCta
AGCCCCAtctcta
aGCCCCATctcta
AGCCCCAtctcta
AGCCCCAtctcta
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.063
-0.121
-0.193
-0.137
-0.143
78594576 rs144907889 G G hsa-miR-2682-3p
hsa-miR-6781-3p
hsa-miR-6819-3p
hsa-miR-6877-3p
2
2
2
2
 cAAGAGGCtgagg
cAAGAGGCtgagg
caAGAGGCTgagg
caAGAGGCTgagg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.086
-0.048
-0.068
-0.105
T hsa-miR-4494
hsa-miR-499b-5p
2
2
 caagAGTCTGAgg
caagAGTCTGAgg
 Created
Created
N
N
 -0.03
-0.033

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