SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_014043
Gene Symbol: CHMP2B
Description: Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA.
Gene Location: chr3(+):87276412-87304698
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.87253832G>C COSN1969937 RK041_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3168 tcaaaAGAACTCatactat
 10
 GAGUUCUA m7a Created -0.166000 -0.166000 No effect
hsa-miR-5584-3p tcaaAAGAACTcatactat
 0 UAGUUCUU m7b Created no TS 0.000000 No effect
hsa-miR-617 tcaaaaGAAGTCatactat
 1
 AGACUUCC m6b Disrupted 0.000000 no TS No effect
hsa-miR-3168 tcaaaAGAACTCatactat
 0 GAGUUCUA m7a Created -0.166 -0.166 No effect
hsa-miR-5584-3p tcaaAAGAACTcatactat
 0 UAGUUCUU m7b Created no TS 0 No effect
hsa-miR-617 tcaaaaGAAGTCatactat
 1
 AGACUUCC m6b Disrupted 0 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr3:g.87254064T>A COSN8489664 J52_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.87254351A>G COSN1969938 RK089_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548at-5p aactgtcaTAACTTTTctt
 2
 AAAAGUUA m8a Disrupted -0.085000 no TS 0.250000
hsa-miR-548at-5p aactgtcaTAACTTTTctt
 0 AAAAGUUA m8a Disrupted -0.085 no TS 0.25

Mutation Mutation ID Sample Name Cancer Type
chr3:g.87254582G>T COSN8489665 J30_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-122-5p tttagACACTCCtctgtta
 0 UGGAGUGU m7b Created no TS -0.144000 -7.570000
hsa-miR-187-3p tttAGACACGcctctgtta
 0 UCGUGUCU m7b (m7b->m6b) -0.200000 no TS 0.360000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
87254033 rs448316 G G hsa-miR-3168
hsa-miR-4277
hsa-miR-4735-5p
hsa-miR-576-5p
10
1
9
9
 taatTAGAACTgt
taattAGAACTGt
tAATTAGAactgt
taATTAGAActgt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.166
-0.213
-0.014
-0.123
A hsa-miR-4328
1
 taattAAAACTGt
 Created
N
 -0.152

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