SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_078487
Gene Symbol: CDKN2B
Description: Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA.
Gene Location: chr9(-):22002901-22009312
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Somatic mutations that impact miRNA target sites




Mutation Mutation ID Sample Name Cancer Type
chr9:g.22003611T>- ICGC_sm163541 RK046_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr9:g.22003887A>T 9_31913 CRC-4-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.22006037T>T ICGC_59229 TCGA-G2-A2EK-01A-22D-A18F-08 BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4268 gccGAGGAGCggggccacc
0 GGCUCCUC m7b (m7b->m6c) -0.172 -0.114 No effect
hsa-miR-4286 gccgaggAGTGGGGccacc
0 ACCCCACU m7b Created no TS -0.063 -3.2
hsa-miR-4758-3p gccgaggaGTGGGGCcacc
0 UGCCCCAC m7b Created no TS -0.179 -0.05
hsa-miR-483-3p gccgAGGAGTGgggccacc
0 UCACUCCU m7b Created -0.251 -0.274 -0.01

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
22006042 rs191233212 A A hsa-miR-4268
8
tggccGAGGAGCg
Disrupted
N
-0.058

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