SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004936
Gene Symbol:	CDKN2B
Description:	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA.
Gene Location:	chr9(-):22002901-22009312
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.22003274T>A			COSN9280321		C0080T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3140-3p	ttttttattAAAAGCaaac	2	AGCUUUUG	m6b	Created	0.022000	-0.033000	-0.070000
hsa-miR-5692a	ttttTTATTTaaagcaaac	0	CAAAUAAU	m6b	Disrupted	0.214000	0.144000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.22003318A>C			COSN2316002		RK061_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1277-5p	cacagtacTATATTacact	2	AAAUAUAU	m6b	Disrupted	0.176000	0.109000	No effect
hsa-miR-1278	caCAGTACTAtattacact	3	UAGUACUG	m8a	(m8a->m7b)	-0.343000	-0.195000	-0.220000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.22003611T>-			ICGC_sm163541		RK046_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.22003887A>T			9_31913		CRC-4-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.22005934A>C			COSN9705636		AOCS-086-3-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4651	caatttcCCACCCCcaccc	0	CGGGGUGG	m7b	Disrupted	-0.252000	no TS	1.620000
hsa-miR-608	caatttcCCACCCCcaccc	0	AGGGGUGG	m7b	Disrupted	-0.280000	no TS	11.030000
hsa-miR-625-5p	caatTTCCCCCccccaccc	0	AGGGGGAA	m7b	Created	no TS	-0.218000	-2.390000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
22003879	rs149822153	-	-	hsa-miR-3140-3p hsa-miR-544a hsa-miR-6071 hsa-miR-6738-3p hsa-miR-6828-3p	2 3 3 3 3	aaAAAAGCAgaaa aaaaaaGCAGAAA aaaaaAGCAGAAa aaaaaaGCAGAAA aaaaaAGCAGAAa	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.004 -0.003 No Change 0.001 No Change
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