| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_058197 |
|---|---|
| Gene Symbol: | CDKN2A |
| Description: | Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1, mRNA. |
| Gene Location: | chr9(-):21967750-21974826 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21970981C>T | ICGC_1364503 | TCGA-A5-A0GP-01A-11W-A062-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1273c |
tcgcgaTGTCGCacggtac |
0 | GGCGACAA | m6b | Disrupted | -0.158 | no TS |
9.2 |
|
| hsa-miR-1973 |
tcgcgatgtTGCACGGTac |
0 | ACCGUGCA | m8a | (m7a->m8a) | no TS | -0.236 |
-5.28 |
|
| hsa-miR-3683 |
tcgcgATGTCGCAcggtac |
0 | UGCGACAU | m8a | Disrupted | -0.301 | no TS |
0.09 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971004A>A | ICGC_60527 | TCGA-G2-A2EO-01A-11D-A17V-08 | BladderUrothelialCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3157-5p |
gaccTGGCTGAggagctgg |
0 | UUCAGCCA | m7b | Disrupted | -0.066 | no TS |
4.39 |
|
| hsa-miR-4268 |
gacctggctGAGGAGCtgg |
0 | GGCUCCUC | m7b | (m7b->m6b) | -0.168 | no TS |
1.09 |
|
| hsa-miR-4448 |
gacctggctAAGGAGCtgg |
0 | GGCUCCUU | m7b | (m6b->m7b) | no TS | -0.111 |
0.3 |
|
| hsa-miR-4691-3p |
gaccTGGCTGaggagctgg |
0 | CCAGCCAC | m6b | Disrupted | -0.063 | no TS |
0.48 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971029G>A | ICGC_1364504 | TCGA-BK-A0CB-01A-32D-A10B-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4645-5p |
cgaTGCCTGGggccgtctg |
0 | ACCAGGCA | m7b | (m7b->m6c) | -0.059 | no TS |
0.02 |
|
| hsa-miR-4673 |
cgaTGCCTGGggccgtctg |
0 | UCCAGGCA | m7b | (m7b->m6c) | -0.077 | no TS |
4.4 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971037A>A | ICGC_60528 | TCGA-G2-A2EO-01A-11D-A17V-08 | BladderUrothelialCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-let-7i-3p |
gacgTGCGCAatgcctggg |
0 | CUGCGCAA | m6b | Created | no TS | -0.187 |
0.13 |
|
| hsa-miR-1256 |
gacgtgcgCAATGCCTggg |
0 | AGGCAUUG | m8a | Created | no TS | -0.022 |
0.01 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971109G>A | ICGC_mut_121 | MBRep_T60 | [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-517a-3p |
cccgTGCACGAcgctgccc |
0 | AUCGUGCA | m7b | Disrupted | -0.117 | no TS |
4.43 |
|
| hsa-miR-517b-3p |
cccgTGCACGAcgctgccc |
0 | AUCGUGCA | m7b | Disrupted | -0.117 | no TS |
4.43 |
|
| hsa-miR-517c-3p |
cccgTGCACGAcgctgccc |
0 | AUCGUGCA | m7b | Disrupted | -0.117 | no TS |
4.43 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971109G>T | ICGC_ssm_v3_38928 | HCC111T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-130a-3p |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.04 |
4.12 |
|
| hsa-miR-130b-3p |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.04 |
2.42 |
|
| hsa-miR-301a-3p |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.047 |
8.02 |
|
| hsa-miR-301b |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.047 |
8.22 |
|
| hsa-miR-3666 |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.044 |
5.67 |
|
| hsa-miR-4295 |
cccgTGCACTacgctgccc |
0 | CAGUGCAA | m6b | Created | no TS | -0.047 |
8.62 |
|
| hsa-miR-4671-3p |
cccgTGCACTAcgctgccc |
0 | UUAGUGCA | m7b | Created | no TS | -0.029 |
-1.36 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.21971121T>T | ICGC_64099 | TCGA-GD-A3OS-01A-12D-A21Z-08 | BladderUrothelialCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-125a-3p |
actcTCACCTGacccgtgc |
0 | ACAGGUGA | m7b | Created | no TS | -0.207 |
-4.73 |
|
| hsa-miR-764 |
actctCACCTGacccgtgc |
0 | GCAGGUGC | m6b | Created | no TS | -0.057 |
0.46 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr9:g.21971187C>T | ICGC_ssm_v3_12926 | BN30T | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-3937 |
ggcagCGCCTGagtggcgg |
0 | ACAGGCGG | m6b | Created | no TS | -0.188 |
-1.48 |
| hsa-miR-4750 |
ggcagCGCCCGAGtggcgg |
0 | CUCGGGCG | m8a | Disrupted | -0.271 | no TS |
-0.02 |
| hsa-miR-510 |
ggcagcgCCTGAGTggcgg |
0 | UACUCAGG | m7b | Created | no TS | -0.064 |
-1.06 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 21971029 | rs121913389 | G | G |
hsa-miR-4645-5p hsa-miR-4673 hsa-miR-874-5p |
4 4 5 |
TGCCTGGggccgt TGCCTGGggccgt tgccTGGGGCCgt |
Disrupted Disrupted Disrupted |
N N N |
-0.059 -0.077 -0.127 |
| A |
hsa-miR-4269 hsa-miR-4514 hsa-miR-4692 hsa-miR-4742-5p hsa-miR-6715b-5p |
4 4 4 4 4 |
TGCCTGAggccgt TGCCTGAggccgt TGCCTGAggccgt TGCCTGAggccgt TGCCTGAggccgt |
Created Created Created Created Created |
N N N N N |
-0.042 -0.016 -0.03 -0.046 -0.042 |
|||
| 21971109 | rs11552822 | G | G |
hsa-miR-4536-3p hsa-miR-517a-3p hsa-miR-517b-3p hsa-miR-517c-3p |
1 1 1 1 |
gTGCACGAcgctg gTGCACGAcgctg gTGCACGAcgctg gTGCACGAcgctg |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.136 -0.117 -0.117 -0.117 |
| T |
hsa-miR-130a-3p hsa-miR-130b-3p hsa-miR-301a-3p hsa-miR-301b hsa-miR-3666 hsa-miR-4295 hsa-miR-454-3p hsa-miR-4671-3p |
1 1 1 1 1 1 1 1 |
gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg gTGCACTAcgctg |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
-0.04 -0.04 -0.047 -0.047 -0.044 -0.047 -0.04 -0.029 |
|||
| 21971110 | rs34968276 | C | C |
hsa-miR-4536-3p hsa-miR-517a-3p hsa-miR-517b-3p hsa-miR-517c-3p |
1 1 1 1 |
cgTGCACGAcgct cgTGCACGAcgct cgTGCACGAcgct cgTGCACGAcgct |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.136 -0.117 -0.117 -0.117 |
| A |
hsa-miR-431-5p |
1 |
cgtGCAAGACgct |
Created |
N |
-0.1 |
|||
| 21971112 | rs121913385 | C | C |
hsa-miR-3177-3p hsa-miR-4536-3p hsa-miR-517a-3p hsa-miR-517b-3p hsa-miR-517c-3p |
0 |
cCCGTGCAcgacg cccgTGCACGAcg cccgTGCACGAcg cccgTGCACGAcg cccgTGCACGAcg |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.188 -0.136 -0.117 -0.117 -0.117 |
| T |
hsa-miR-602 |
0 |
CCCGTGTAcgacg |
Created |
N |
-0.397 |
|||
| 21971121 | rs121913388 | C | |||||||
| T |
hsa-miR-125a-3p hsa-miR-3934-5p hsa-miR-764 |
16 16 16 |
cTCACCTGAcccg ctCACCTGAcccg ctCACCTGAcccg |
Created Created Created |
N N N |
-0.207 -0.052 -0.057 |
|||
| 21971187 | rs121913387 | C | C |
hsa-miR-4750-5p hsa-miR-6499-5p |
5 2 |
agCGCCCGAgtgg aGCGCCCGAgtgg |
Disrupted Disrupted |
N N |
-0.271 -0.611 |
| T |
hsa-miR-3937 hsa-miR-510-5p |
5 5 |
agCGCCTGAgtgg agcgCCTGAGTgg |
Created Created |
N N |
-0.188 -0.064 |