SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_058195
Gene Symbol:	CDKN2A
Description:	Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1, mRNA.
Gene Location:	chr9(-):21967750-21994490
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.21970981C>T			ICGC_1364503		TCGA-A5-A0GP-01A-11W-A062-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273c	tcgcgaTGTCGCacggtac	0	GGCGACAA	m6b	Disrupted	-0.202	no TS	16.14
hsa-miR-1973	tcgcgatgtTGCACGGTac	0	ACCGUGCA	m8a	(m7a->m8a)	no TS	-0.278	-5.07
hsa-miR-3683	tcgcgATGTCGCAcggtac	0	UGCGACAU	m8a	Disrupted	-0.364	no TS	0.59

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
21970980	rs6413464	G	G	hsa-miR-1273c hsa-miR-3683	3 3	gaTGTCGCAcggt gATGTCGCAcggt	Disrupted Disrupted	N N	-0.202 -0.364
			T	hsa-miR-4524a-3p	3	gaTGTCTCAcggt	Created	N	-0.049
21970982	rs104894098	T	T	hsa-miR-1273c hsa-miR-3683	3 3	gcgaTGTCGCAcg gcgATGTCGCAcg	Disrupted Disrupted	N N	-0.202 -0.364
			A	hsa-miR-6785-3p	2	GCGATGAcgcacg	Created	N	-0.168

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