SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000389
Gene Symbol: CDKN1A
Description: Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 1, mRNA.
Gene Location: chr6(+):36646455-36655116
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.36686315G>T COSN8514252 J30_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1283 aaaacTTTGTAGtcccctc
0 UCUACAAA m7b Created no TS 0.052000 -3.590000
hsa-miR-3145-5p aaaactTTGGAGTcccctc
0 AACUCCAA m7b Disrupted -0.323000 -0.283000 0.070000
hsa-miR-3973 aaaACTTTGTagtcccctc
9
ACAAAGUA m7a (m6a->m7a) 0.011000 0.011000 No effect
hsa-miR-520d-5p aaaaCTTTGTAGtcccctc
0 CUACAAAG m8a Created no TS 0.010000 -8.890000
hsa-miR-520g aaaACTTTGTagtcccctc
9
ACAAAGUG m7a (m6a->m7a) -0.210000 -0.210000 -1.060000
hsa-miR-520h aaaACTTTGTagtcccctc
9
ACAAAGUG m7a (m6a->m7a) -0.210000 -0.210000 -0.910000
hsa-miR-524-5p aaaaCTTTGTAGtcccctc
0 CUACAAAG m8a Created no TS 0.038000 -3.780000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.36686647C>T COSN8514253 308_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3160-3p gtaccctcTCAGCTCcagg
9
AGAGCUGA m7b Disrupted -0.127000 -0.099000 1.510000
hsa-miR-4633-3p gtaccctctTAGCTCCagg
2
AGGAGCUA m7b (m6c->m7b) -0.079000 -0.212000 -0.820000
hsa-miR-610 gtaccctcTTAGCTCcagg
0 UGAGCUAA m7b Created no TS -0.012000 -10.290000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.36687005G>C COSN9781735 AOCS-106-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103b gcagtagaGGCTATGgaca
0 UCAUAGCC m7b Disrupted -0.182000 no TS 1.470000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
36687269 rs71803037 - CA 0
- hsa-miR-3160-3p
hsa-miR-4766-5p
5
2
tgtcttTCAGCTC
tgtCTTTCAGctc
Unknown
Unknown
N
N
-0.233
-0.085

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