SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_000389 |
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Gene Symbol: | CDKN1A |
Description: | Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 1, mRNA. |
Gene Location: | chr6(+):36646455-36655116 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.36686315G>T | COSN8514252 | J30_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1283 |
aaaacTTTGTAGtcccctc |
0 | UCUACAAA | m7b | Created | no TS | 0.052000 |
-3.590000 |
|
hsa-miR-3145-5p |
aaaactTTGGAGTcccctc |
0 | AACUCCAA | m7b | Disrupted | -0.323000 | -0.283000 |
0.070000 |
|
hsa-miR-3973 |
aaaACTTTGTagtcccctc |
9 |
ACAAAGUA | m7a | (m6a->m7a) | 0.011000 | 0.011000 | No effect | |
hsa-miR-520d-5p |
aaaaCTTTGTAGtcccctc |
0 | CUACAAAG | m8a | Created | no TS | 0.010000 |
-8.890000 |
|
hsa-miR-520g |
aaaACTTTGTagtcccctc |
9 |
ACAAAGUG | m7a | (m6a->m7a) | -0.210000 | -0.210000 |
-1.060000 |
|
hsa-miR-520h |
aaaACTTTGTagtcccctc |
9 |
ACAAAGUG | m7a | (m6a->m7a) | -0.210000 | -0.210000 |
-0.910000 |
|
hsa-miR-524-5p |
aaaaCTTTGTAGtcccctc |
0 | CUACAAAG | m8a | Created | no TS | 0.038000 |
-3.780000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.36686647C>T | COSN8514253 | 308_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3160-3p |
gtaccctcTCAGCTCcagg |
9 |
AGAGCUGA | m7b | Disrupted | -0.127000 | -0.099000 |
1.510000 |
|
hsa-miR-4633-3p |
gtaccctctTAGCTCCagg |
2 |
AGGAGCUA | m7b | (m6c->m7b) | -0.079000 | -0.212000 |
-0.820000 |
|
hsa-miR-610 |
gtaccctcTTAGCTCcagg |
0 | UGAGCUAA | m7b | Created | no TS | -0.012000 |
-10.290000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr6:g.36687005G>C | COSN9781735 | AOCS-106-1-1 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-103b |
gcagtagaGGCTATGgaca |
0 | UCAUAGCC | m7b | Disrupted | -0.182000 | no TS |
1.470000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
36687269 | rs71803037 | - | CA | 0 |
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- |
hsa-miR-3160-3p hsa-miR-4766-5p |
5 2 |
tgtcttTCAGCTC tgtCTTTCAGctc |
Unknown Unknown |
N N |
-0.233 -0.085 |