SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001145306
Gene Symbol: CDK6
Description: Homo sapiens cyclin-dependent kinase 6 (CDK6), transcript variant 2, mRNA.
Gene Location: chr7(-):92234234-92465941
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.92606195C>G COSN8046958 8067211 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-526b-5p aaaactaaTCAAGAatata
 5
 CUCUUGAG m6b Disrupted -0.045000 -0.056000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92606334G>T COSN9515964 AOCS-085-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3914 ctagagatGGTTCCTgatg
 2
 AAGGAACC m7b Disrupted -0.072000 -0.016000 0.070000
hsa-miR-4261 ctagagaTGTTTCCTgatg
 5
 AGGAAACA m8a Created 0.105000 0.189000 No effect
hsa-miR-4496 ctagagatGTTTCCTgatg
 2
 GAGGAAAC m7b Created 0.244000 0.297000 No effect
hsa-miR-494 ctagagATGTTTCctgatg
 2
 UGAAACAU m7b Created 0.382000 0.524000 No effect
hsa-miR-873-5p ctagagatgGTTCCTGatg
 6
 GCAGGAAC m7b (m7b->m6b) 0.049000 0.066000 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92606426C>T COSN8046959 8031121 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3663-3p catGGTGCTCtccatcttc
 1
 UGAGCACC m7b (m7b->m6c) -0.119000 -0.062000 2.060000
hsa-miR-3688-3p catggtgcTTTCCATcttc
 3
 UAUGGAAA m7b Created 0.171000 0.345000 No effect
hsa-miR-3978 catggtgCTTTCCAtcttc
 0 GUGGAAAG m7b Created 0.087000 0.194000 -0.220000
hsa-miR-4534 catggtgctCTCCATCttc
 6
 GGAUGGAG m7b (m7b->m6b) -0.018000 -0.054000 No effect
hsa-miR-5192 catggtgCTCTCCatcttc
 2
 AGGAGAGU m6b Disrupted -0.349000 -0.365000 5.200000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92607172G>T 0_270 Small cell lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3183 tgttGAGAGGagagcagtg
 7
 GCCUCUCU m6b Disrupted 0.191 0.167 No effect
hsa-miR-4279 tgttgaGAGGAGAGcagtg
 6
 CUCUCCUC m8a Disrupted -0.251 -0.307 No effect
hsa-miR-4723-3p tgttGAGAGGagagcagtg
 7
 CCCUCUCU m6b Disrupted 0.162 0.135 0.04

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92608638A>T COSN9774134 C0031T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130b-5p tcgggtaaAAAGAGatgcg
 2
 ACUCUUUC m6b Disrupted 0.375000 0.239000 No effect
hsa-miR-138-2-3p tcgggtAAATAGagatgcg
 0 GCUAUUUC m6b Created no TS 0.193000 No effect
hsa-miR-2681-5p tcgGGTAAAAagagatgcg
 1
 GUUUUACC m7b (m7b->m6c) 0.695000 0.491000 1.320000
hsa-miR-3675-3p tcgggtaaaTAGAGATGcg
 2
 CAUCUCUA m8a (m7a->m8a) 0.113000 0.196000 No effect
hsa-miR-4699-3p tcggGTAAATagagatgcg
 0 AAUUUACU m6b Created 0.238000 0.423000 No effect
hsa-miR-4753-3p tcgggtaaAAAGAGAtgcg
 2
 UUCUCUUU m7b Disrupted 0.404000 0.282000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92608996G>A COSN7659724 PCSI_0356_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-153 cccCTATGCAAaaggccga
 0 UUGCAUAG m8a Created no TS 0.098000 -0.020000
hsa-miR-3680-3p cccctATGCAAAAggccga
 0 UUUUGCAU m8a Created 0.206000 0.417000 -2.060000
hsa-miR-448 ccccTATGCAAaaggccga
 9
 UUGCAUAU m7a Created -0.050000 0.042000 No effect
hsa-miR-557 cccctaTGCAAAaggccga
 0 GUUUGCAC m6b Created 0.228000 0.340000 -0.160000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92609132A>T COSN2243924 RK061_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20a-3p tgagtggcATGCAGatgag
 11
 ACUGCAUU m6b Created 0.028000 0.086000 No effect
hsa-miR-4327 tgagtgGCAAGCagatgag
 2
 GGCUUGCA m6b Disrupted -0.017000 no TS No effect
hsa-miR-4686 tgagtggcaAGCAGATgag
 2
 UAUCUGCU m7b (m7b->m6b) 0.044000 0.007000 0.860000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92609253T>G COSN4935855 PD4109a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-513a-3p cttGAAATTTAgtagggaa
 0 UAAAUUUC m8a Disrupted 0.951000 0.682000 1.390000
hsa-miR-513c-3p cttGAAATTTAgtagggaa
 0 UAAAUUUC m8a Disrupted 0.951000 0.682000 0.480000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610064A>T COSN14566536 8064157 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2115-3p acaaaTCTGATGaagacta
 2
 CAUCAGAA m7a Disrupted 0.167000 0.167000 No effect
hsa-miR-421 acaaatCTGTTGAagacta
 13
 AUCAACAG m7b Created -0.011000 0.005000 -0.010000
hsa-miR-4709-5p acaaatCTGTTGaagacta
 4
 ACAACAGU m6b Created 0.163000 0.188000 No effect
hsa-miR-676-5p acaaatctGTTGAAGActa
 0 UCUUCAAC m8a Created no TS 0.066000 -0.180000
hsa-miR-2115-3p acaaaTCTGATGaagacta
 2
 CAUCAGAA m7a Disrupted 0.167000 0.167000 No effect
hsa-miR-421 acaaatCTGTTGAagacta
 13
 AUCAACAG m7b Created -0.011000 0.005000 -0.010000
hsa-miR-4709-5p acaaatCTGTTGaagacta
 4
 ACAACAGU m6b Created 0.163000 0.188000 No effect
hsa-miR-676-5p acaaatctGTTGAAGActa
 0 UCUUCAAC m8a Created no TS 0.066000 -0.180000
hsa-miR-2115-3p acaaaTCTGATGaagacta
 2
 CAUCAGAA m7a Disrupted 0.167000 0.167000 No effect
hsa-miR-421 acaaatCTGTTGAagacta
 13
 AUCAACAG m7b Created -0.011000 0.005000 -0.010000
hsa-miR-4709-5p acaaatCTGTTGaagacta
 4
 ACAACAGU m6b Created 0.163000 0.188000 No effect
hsa-miR-676-5p acaaatctGTTGAAGActa
 0 UCUUCAAC m8a Created no TS 0.066000 -0.180000
hsa-miR-2115-3p acaaaTCTGATGaagacta
 2
 CAUCAGAA m7a Disrupted 0.167000 0.167000 No effect
hsa-miR-421 acaaatCTGTTGAagacta
 13
 AUCAACAG m7b Created -0.011000 0.005000 -0.010000
hsa-miR-4709-5p acaaatCTGTTGaagacta
 4
 ACAACAGU m6b Created 0.163000 0.188000 No effect
hsa-miR-676-5p acaaatctGTTGAAGActa
 0 UCUUCAAC m8a Created no TS 0.066000 -0.180000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610075A>G COSN14565661 8064157 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2116-5p tttagagAAGAACaaatct
 0 GGUUCUUA m6b Created 0.338000 0.404000 No effect
hsa-miR-22-5p tttagaGAAGAACaaatct
 0 AGUUCUUC m7b Created no TS 0.020000 No effect
hsa-miR-4273 tttagagaAGAACAaatct
 4
 GUGUUCUC m6b Created -0.059000 0.017000 No effect
hsa-miR-4659a-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4659b-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4677-5p tttagagAAGAACAAatct
 0 UUGUUCUU m8a Created no TS 0.121000 No effect
hsa-miR-942 tttAGAGAAGAacaaatct
 12
 UCUUCUCU m8a Created -0.133000 -0.124000 No effect
hsa-miR-2116-5p tttagagAAGAACaaatct
 0 GGUUCUUA m6b Created 0.338000 0.404000 No effect
hsa-miR-22-5p tttagaGAAGAACaaatct
 0 AGUUCUUC m7b Created no TS 0.020000 No effect
hsa-miR-4273 tttagagaAGAACAaatct
 4
 GUGUUCUC m6b Created -0.059000 0.017000 No effect
hsa-miR-4659a-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4659b-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4677-5p tttagagAAGAACAAatct
 0 UUGUUCUU m8a Created no TS 0.121000 No effect
hsa-miR-942 tttAGAGAAGAacaaatct
 12
 UCUUCUCU m8a Created -0.133000 -0.124000 No effect
hsa-miR-2116-5p tttagagAAGAACaaatct
 0 GGUUCUUA m6b Created 0.338000 0.404000 No effect
hsa-miR-22-5p tttagaGAAGAACaaatct
 0 AGUUCUUC m7b Created no TS 0.020000 No effect
hsa-miR-4273 tttagagaAGAACAaatct
 4
 GUGUUCUC m6b Created -0.059000 0.017000 No effect
hsa-miR-4659a-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4659b-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4677-5p tttagagAAGAACAAatct
 0 UUGUUCUU m8a Created no TS 0.121000 No effect
hsa-miR-942 tttAGAGAAGAacaaatct
 12
 UCUUCUCU m8a Created -0.133000 -0.124000 No effect
hsa-miR-2116-5p tttagagAAGAACaaatct
 0 GGUUCUUA m6b Created 0.338000 0.404000 No effect
hsa-miR-22-5p tttagaGAAGAACaaatct
 0 AGUUCUUC m7b Created no TS 0.020000 No effect
hsa-miR-4273 tttagagaAGAACAaatct
 4
 GUGUUCUC m6b Created -0.059000 0.017000 No effect
hsa-miR-4659a-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4659b-3p tttagAGAAGAAcaaatct
 6
 UUUCUUCU m7b Created 0.296000 0.403000 No effect
hsa-miR-4677-5p tttagagAAGAACAAatct
 0 UUGUUCUU m8a Created no TS 0.121000 No effect
hsa-miR-942 tttAGAGAAGAacaaatct
 12
 UCUUCUCU m8a Created -0.133000 -0.124000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610554A>G COSN4922528 CPCG_0042_Pr_P_F0 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-3p agcatttCTATCTTgtact
 6
 AAAGAUAG m7b Disrupted 0.193000 0.209000 0.980000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610554A>T COSN8572893 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-3p agcatttCTATCTTgtact
 6
 AAAGAUAG m7b Disrupted 0.193000 0.209000 1.120000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610554A>G ICGC_68FD8F24-2A78-11E2-B3FD-00FD496BB9B8 CPCG_0042_Pr_P_F0 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-3p agcatttCTATCTTgtact
 0 AAAGAUAG m7b Disrupted 0.193 0.209 0.98

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610559T>C COSN8572894 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302a-3p tctcaAGCACTTctatctt
 8
 UAAGUGCU m7b Created -0.020000 -0.015000 -2.100000
hsa-miR-302b-3p tctcaAGCACTTctatctt
 8
 UAAGUGCU m7b Created -0.020000 -0.015000 -0.610000
hsa-miR-302c-3p tctcaAGCACTTctatctt
 8
 UAAGUGCU m7b Created -0.020000 -0.015000 -0.350000
hsa-miR-302d-3p tctcaAGCACTTctatctt
 8
 UAAGUGCU m7b Created -0.020000 -0.015000 -0.810000
hsa-miR-302e tctcaAGCACTTctatctt
 8
 UAAGUGCU m7b Created 0.018000 0.023000 -0.430000
hsa-miR-372 tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.010000 -0.014000 -0.010000
hsa-miR-373-3p tctcaAGCACTTCtatctt
 8
 GAAGUGCU m8a Created -0.001000 -0.005000 -2.650000
hsa-miR-4795-5p tctcaagCACTTCTatctt
 0 AGAAGUGG m7a Created NA NA -0.030000
hsa-miR-520a-3p tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.001000 0.004000 -0.200000
hsa-miR-520b tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.010000 -0.024000 -1.340000
hsa-miR-520c-3p tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.010000 -0.024000 -1.650000
hsa-miR-520d-3p tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.001000 0.004000 -1.400000
hsa-miR-520e tctcaAGCACTTctatctt
 8
 AAAGUGCU m7b Created -0.001000 -0.005000 -2.000000
hsa-miR-520f tctcAAGCACTTctatctt
 1
 AAGUGCUU m8a Created -0.017000 -0.030000 -0.040000
hsa-miR-5680 tctcaagCATTTCTatctt
 10
 GAGAAAUG m7b Disrupted 1.248000 1.070000 0.160000
hsa-miR-636 tctCAAGCACttctatctt
 6
 UGUGCUUG m7b (m6c->m7b) 0.071000 0.043000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92610585T>C COSN8572895 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4282 caacccAATTTTAatacat
 3
 UAAAAUUU m7a Disrupted 2.144000 1.907000 No effect
hsa-miR-4477a caacccaatCTTAATAcat
 0 CUAUUAAG m7b (m6b->m7b) no TS 0.078000 -2.020000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92612239T>C COSN7659725 ASHPC_0007_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-498 gaaatcatGCTTGAAtttc
 2
 UUUCAAGC m7b Created 0.455000 0.450000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92613022A>G COSN6898757 RK210_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-101-3p gtcaGTACTGTAaatgctt
 9
 UACAGUAC m8a Created 0.099000 0.091000 -1.650000
hsa-miR-1278 gtCAGTACTAtaaatgctt
 2
 UAGUACUG m8a (m8a->m7b) 0.022000 0.046000 0.030000
hsa-miR-144-3p gtcagTACTGTAaatgctt
 2
 UACAGUAU m7a Created 0.030000 0.083000 No effect
hsa-miR-4729 gtcagtactATAAATGctt
 8
 UCAUUUAU m7b (m7b->m6b) 0.468000 0.327000 No effect
hsa-miR-582-5p gtcagtACTGTAAatgctt
 4
 UUACAGUU m7a Created -0.140000 -0.084000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92613312A>G COSN15438115 AOCS-088-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1200 tgcaCTCAGGAaataattc
 9
 CUCCUGAG m7b Created 0.021000 -0.024000 -0.040000
hsa-miR-3074-5p tgcactCAGGAAataattc
 2
 GUUCCUGC m6b Created -0.119000 -0.071000 No effect
hsa-miR-378a-5p tgcacTCAGGAaataattc
 10
 CUCCUGAC m6b Created 0.072000 0.078000 No effect
hsa-miR-4303 tgcaCTCAGAAaataattc
 0 UUCUGAGC m7a Disrupted 0.029000 no TS 0.020000
hsa-miR-4324 tgcaCTCAGGaaataattc
 10
 CCCUGAGA m6b Created 0.097000 0.083000 -1.970000
hsa-miR-4682 tgcACTCAGAaaataattc
 0 UCUGAGUU m7a (m7a->m6b) 0.047000 0.034000 -0.070000
hsa-miR-4762-3p tgcacTCAGAAaataattc
 2
 CUUCUGAU m6b Disrupted 0.186000 0.113000 No effect
hsa-miR-544b tgcaCTCAGGaaataattc
 11
 ACCUGAGG m6b Created -0.118000 -0.116000 No effect
hsa-miR-1200 tgcaCTCAGGAaataattc
 9
 CUCCUGAG m7b Created 0.021000 -0.024000 -0.040000
hsa-miR-3074-5p tgcactCAGGAAataattc
 2
 GUUCCUGC m6b Created -0.119000 -0.071000 No effect
hsa-miR-378a-5p tgcacTCAGGAaataattc
 10
 CUCCUGAC m6b Created 0.072000 0.078000 No effect
hsa-miR-4303 tgcaCTCAGAAaataattc
 0 UUCUGAGC m7a Disrupted 0.029000 no TS 0.020000
hsa-miR-4324 tgcaCTCAGGaaataattc
 10
 CCCUGAGA m6b Created 0.097000 0.083000 -1.970000
hsa-miR-4682 tgcACTCAGAaaataattc
 0 UCUGAGUU m7a (m7a->m6b) 0.047000 0.034000 -0.070000
hsa-miR-4762-3p tgcacTCAGAAaataattc
 2
 CUUCUGAU m6b Disrupted 0.186000 0.113000 No effect
hsa-miR-544b tgcaCTCAGGaaataattc
 11
 ACCUGAGG m6b Created -0.118000 -0.116000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.92613629C>T COSN6597360 ICGC_MB91 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273f ttctCCATCTCCcaggctg
 0 GGAGAUGG m8a Created 0.029000 0.057000 -0.010000
hsa-miR-1275 ttctccaTCCCCCAggctg
 5
 GUGGGGGA m7b Disrupted -0.111000 -0.088000 0.010000
hsa-miR-30c-1-3p ttctccaTCTCCCAGgctg
 2
 CUGGGAGA m8a Created 0.050000 0.093000 -0.010000
hsa-miR-30c-2-3p ttctccaTCTCCCAGgctg
 2
 CUGGGAGA m8a Created 0.050000 0.093000 -0.010000
hsa-miR-3192 ttctccatCTCCCAGgctg
 0 UCUGGGAG m7b Created 0.050000 0.031000 -0.040000
hsa-miR-4525 ttctccATCCCCCaggctg
 2
 GGGGGGAU m7b Disrupted -0.027000 -0.009000 0.010000
hsa-miR-4534 ttCTCCATCCcccaggctg
 6
 GGAUGGAG m8a (m8a->m7b) -0.018000 -0.045000 -0.530000
hsa-miR-4665-5p ttctccaTCCCCCAGgctg
 5
 CUGGGGGA m8a Disrupted -0.127000 -0.085000 No effect
hsa-miR-5010-5p ttctccATCCCCCaggctg
 2
 AGGGGGAU m7b Disrupted -0.078000 -0.028000 2.350000
hsa-miR-625-5p ttctccaTCCCCCaggctg
 5
 AGGGGGAA m6b Disrupted -0.023000 no TS 0.090000
hsa-miR-637 ttctccatCCCCCAGgctg
 5
 ACUGGGGG m7b Disrupted -0.128000 -0.069000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr7:g.92613790G>A COSN14533677 8068588 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.92614270T>A COSN8046962 8062308 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4668-3p gataGATTTTaaaaaaaag
 0 GAAAAUCC m6b Disrupted 0.819000 0.755000 No effect
hsa-miR-4668-3p gataGATTTTaaaaaaaag
 0 GAAAAUCC m6b Disrupted 0.819000 0.755000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
92607814 rs148984125 - T hsa-miR-570-3p
4
 tTGTTTTCctatt
 Unknown
N
 0.048
- hsa-miR-4261
hsa-miR-4496
4
4
 tTGTTTCCtatt
ttGTTTCCTAtt
 Unknown
Unknown
N
N
 -0.034
-0.07
92608050 rs191304750 C C hsa-miR-1297
hsa-miR-26a-5p
hsa-miR-26b-5p
hsa-miR-4465
hsa-miR-498
hsa-miR-5697
10
10
10
10
9
10
 ccctTACTTGAAa
ccctTACTTGAAa
ccctTACTTGAAa
ccctTACTTGAAa
cccttaCTTGAAA
ccctTACTTGAaa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
LT
LT
N
N
N
 0.077
0.088
0.088
0.088
0.084
0.079
T hsa-miR-3671
hsa-miR-607
10
9
 ccctTATTTGAAa
cccttATTTGAAA
 Created
Created
N
N
 0.207
0.25
92608112 rs42032 T C hsa-miR-7845-5p
0 tgtgGTCCCTAga
 Created
N
 -0.04
T hsa-miR-3914
0 tgtGGTTCCTAga
 Disrupted
N
 -0.089
92608520 rs74960681 T
A hsa-miR-3074-5p
hsa-miR-3606-3p
hsa-miR-4282
hsa-miR-513a-3p
hsa-miR-513c-3p
hsa-miR-7152-5p
10
11
13
11
11
10
 CAGGAAAtttttt
cagGAAATTTttt
caggAAATTTTtt
cagGAAATTTttt
cagGAAATTTttt
CAGGAAAtttttt
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.004
0.121
0.198
0.121
0.121
-0.02
92609310 rs188870214 C C hsa-miR-3170
hsa-miR-4260
hsa-miR-450a-2-3p
hsa-miR-5572
hsa-miR-579-3p
hsa-miR-664b-3p
hsa-miR-6737-5p
hsa-miR-6812-5p
hsa-miR-6819-5p
hsa-miR-6855-5p
hsa-miR-6881-5p
1
3
3
1
21
21
1
1
1
1
1
 atACCCCAAatga
ataCCCCAAAtga
ataCCCCAAAtga
atACCCCAAAtga
atacccCAAATGA
atacccCAAATGA
atACCCCAAatga
atACCCCAAatga
atACCCCAAatga
atACCCCAAatga
aTACCCCAaatga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
N
 -0.079
-0.064
-0.037
-0.15
0.077
0.115
-0.066
-0.066
-0.066
-0.076
-0.097
T hsa-miR-2909
hsa-miR-4729
hsa-miR-5696
hsa-miR-6755-5p
hsa-miR-6841-5p
3
21
21
1
1
 ataCCCTAAAtga
atacccTAAATGA
atacccTAAATGA
aTACCCTAaatga
aTACCCTAaatga
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.035
0.141
0.145
-0.058
-0.074
92610217 rs42035 T T hsa-miR-132-3p
hsa-miR-144-3p
hsa-miR-16-1-3p
hsa-miR-194-5p
hsa-miR-212-3p
2
2
2
3
2
 aaatACTGTTAca
aaATACTGTtaca
aAATACTGttaca
aaataCTGTTACA
aaatACTGTTAca
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
LT
N
N
 0.062
0.011
0.037
0.03
0.066
92610300 rs147757451 T T hsa-miR-338-5p
2
 aacATATTGTtac
 Disrupted
N
 0.15
C hsa-miR-132-3p
hsa-miR-144-3p
hsa-miR-194-5p
hsa-miR-212-3p
hsa-miR-567
2
2
2
2
2
 aacatACTGTTAc
aacATACTGTtac
aacataCTGTTAC
aacatACTGTTAc
AACATACtgttac
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.083
0.074
0.022
0.083
0.07
92610866 rs55741533 - T hsa-miR-548c-3p
4
 aATTTTTAaaagg
 Unknown
N
 0.214
- hsa-miR-4282
3
 AATTTTAaaagg
 Unknown
N
 0.152
92610888 rs141085929 G
A hsa-miR-2116-5p
hsa-miR-22-5p
hsa-miR-4677-5p
0 AAGAACAttcatt
AAGAACAttcatt
AAGAACAttcatt
 Created
Created
Created
N
N
N
 0.027
0.073
0.058
92611948 rs74980371 G G hsa-miR-500a-3p
hsa-miR-507
hsa-miR-557
hsa-miR-6804-3p
5
6
11
5
 ctcaAGGTGCAAa
ctcaagGTGCAAA
ctcaagGTGCAAA
ctcaAGGTGCAaa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.075
0.077
0.096
-0.019
A hsa-miR-3680-3p
hsa-miR-526b-5p
6
3
 ctcaagATGCAAA
CTCAAGAtgcaaa
 Created
Created
N
N
 0.14
0.005
92612411 rs150253716 G G hsa-miR-3977
hsa-miR-4686
9
2
 ttTGAAGCAgata
tttgaAGCAGATA
 Disrupted
Disrupted
N
N
 -0.018
0.007
A hsa-miR-607
7
 TTTGAAAcagata
 Created
N
 0.187
92612527 rs191315649 G
A hsa-miR-3134
hsa-miR-4534
hsa-miR-6757-3p
hsa-miR-8082
2
2
1
2
 TCCATCAgtgtag
TCCATCAgtgtag
tccatCAGTGTAg
TCCATCAgtgtag
 Created
Created
Created
Created
N
N
N
N
 0.021
0.038
0.045
0.038
92612669 rs114715342 T T hsa-miR-1252-3p
hsa-miR-5680
hsa-miR-6508-5p
hsa-miR-8067
5
3
3
3
 CTCATTTctaggc
ctCATTTCTAggc
ctcaTTTCTAGgc
ctcaTTTCTAGgc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 0.111
0.213
0.105
0.086
C hsa-miR-3135a
2
 ctcattCCTAGGC
 Created
N
 -0.137
92613389 rs73710416 T T hsa-miR-4666b
hsa-miR-4684-3p
hsa-miR-5011-3p
2
2
2
 agtgCATGCAAca
agtgcaTGCAACA
agtgCATGCAAca
 Disrupted
Disrupted
Disrupted
N
N
N
 0.03
0.031
0.032
A hsa-miR-1273e
hsa-miR-4325
hsa-miR-4327
hsa-miR-7703
2
7
3
7
 agtgCAAGCAAca
AGTGCAAgcaaca
agTGCAAGCAaca
AGTGCAAgcaaca
 Created
Created
Created
Created
N
N
N
N
 0.038
0.01
-0.036
-0.009
92613953 rs183424870 C C hsa-miR-1292-5p
hsa-miR-4471
hsa-miR-8059
4
4
4
 gctGTTCCCAtgc
gctGTTCCCAtgc
gctGTTCCCAtgc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.05
-0.039
-0.036
T hsa-miR-3688-3p
hsa-miR-4261
4
4
 gctgTTTCCATgc
gcTGTTTCCAtgc
 Created
Created
N
N
 0.105
0.03
92614269 rs42037 A A hsa-miR-4668-3p
1
 GATTTTAaaaaaa
 Disrupted
N
 0.064
T hsa-miR-548c-3p
1
 GATTTTTAaaaaa
 Created
N
 0.099
92614879 rs3731389 G G hsa-miR-1236-3p
hsa-miR-4753-3p
hsa-miR-4778-3p
hsa-miR-6515-3p
hsa-miR-6809-3p
hsa-miR-942-5p
11
12
9
11
12
12
 gaaGAAGAGAagc
gaagAAGAGAAgc
GAAGAAGAgaagc
gaaGAAGAGAagc
gaagAAGAGAAgc
gaagaAGAGAAGc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.064
-0.026
-0.185
-0.068
-0.012
-0.133
A hsa-miR-103a-2-5p
hsa-miR-4659a-3p
hsa-miR-4659b-3p
hsa-miR-627-3p
hsa-miR-6875-3p
13
9
9
9
9
 gaagaaAAGAAGC
GAAGAAAagaagc
GAAGAAAagaagc
gaAGAAAAGAagc
GAAGAAAagaagc
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.146
-0.096
-0.096
-0.122
-0.012

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