SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004360
Gene Symbol: CDH1
Description: Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.
Gene Location: chr16(+):68771194-68869444
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr16:g.68833862G>A COSN7269152 8031121 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3127-3p aaaGAAGGGGAgaagtcag
 3
 UCCCCUUC m8a Disrupted -0.405000 no TS 0.010000
hsa-miR-4755-5p aaagAAGGGAAgaagtcag
 0 UUUCCCUU m7b Created no TS -0.093000 -0.080000
hsa-miR-4778-3p aaagaaggGAAGAAGtcag
 2
 UCUUCUUC m7b Created -0.026000 -0.086000 -2.840000
hsa-miR-5006-3p aaagAAGGGAAgaagtcag
 0 UUUCCCUU m7b Created no TS -0.102000 No effect
hsa-miR-623 aaagAAGGGAagaagtcag
 0 AUCCCUUG m6b Created no TS -0.112000 -0.450000
hsa-miR-629-3p aaagaagGGGAGAAgtcag
 2
 GUUCUCCC m7b Disrupted -0.265000 -0.120000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr16:g.68834125T>A COSN7269153 8062308 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr16:g.68834753C>T COSN8601916 J90_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr16:g.68835430C>T COSN7269154 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-21-3p gtgtgGGTGTTGataattg
 0 CAACACCA m7a Created NA NA No effect
hsa-miR-3065-3p gtgtgGGTGCTGAtaattg
 10
 UCAGCACC m8a Disrupted -0.448000 no TS 0.230000
hsa-miR-374a-3p gtgtgggtgCTGATAAttg
 0 CUUAUCAG m7b (m7b->m6c) -0.093000 no TS 1.410000
hsa-miR-421 gtgtgggTGTTGATaattg
 1
 AUCAACAG m7a Created -0.086000 -0.086000 -1.830000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
68833600 rs1138533 G G hsa-miR-2355-5p
hsa-miR-3679-3p
hsa-miR-4446-5p
2
1
1
 ttCTGGGGAAaaa
ttctGGGGAAAaa
ttctgGGGAAAAa
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.488
-0.181
-0.11
A hsa-miR-3925-3p
hsa-miR-515-5p
hsa-miR-519e-5p
hsa-miR-629-3p
hsa-miR-766-3p
2
2
2
1
2
 ttCTGGAGAaaaa
ttcTGGAGAAaaa
ttcTGGAGAAaaa
ttctGGAGAAAaa
ttCTGGAGAaaaa
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.177
-0.153
-0.147
-0.111
-0.155

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