SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002985
Gene Symbol: CCL5
Description: Homo sapiens chemokine (C-C motif) ligand 5 (CCL5), mRNA.
Gene Location: chr17(-):34198495-34207377
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.35871796T>G ICGC_8C3E5A04-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-143-5p tgtgccACTGCACtccagc
 0 GGUGCAGU m7b Created -0.211 -0.323 -0.01
hsa-miR-3616-5p tgtgcCACTTCActccagc
 0 AUGAAGUG m7b Disrupted -0.037 no TS 6.13
hsa-miR-4795-5p tgtgCCACTTCactccagc
 0 AGAAGUGG m7b Disrupted -0.248 no TS 10.55
hsa-miR-5693 tgtGCCACTGCactccagc
 0 GCAGUGGC m8a Created -0.06 -0.239 0.99
hsa-miR-573 tgtgcCACTTCActccagc
 0 CUGAAGUG m7b Disrupted -0.037 no TS 4.42

Mutation Mutation ID Sample Name Cancer Type
chr17:g.35872073A>G ICGC_E6C3AC54-2A78-11E2-9A67-27FD496BB9B8 CPCG_0103_Pr_P_P7 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4258 gggcgtggTGGCGGGcgcc
 0 CCCCGCCA m7b Created no TS -0.188 -6.85
hsa-miR-4707-3p gggcgtggtGGCGGGCgcc
 0 AGCCCGCC m7b (m6b->m7b) no TS -0.284 -5.69

Mutation Mutation ID Sample Name Cancer Type
chr17:g.35872111A>G ICGC_B86E63E4-2A78-11E2-A284-1BFD496BB9B8 CPCG_0103_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273f tgaaaccCCATCTCtacta
 0 GGAGAUGG m7b Disrupted -0.166 no TS No effect
hsa-miR-193b-5p tgAAACCCCGtctctacta
 0 CGGGGUUU m8a (m7b->m8a) -0.312 -0.145 -0.01
hsa-miR-3170 tgaAACCCCAtctctacta
 0 CUGGGGUU m7b (m7b->m6c) -0.218 no TS No effect
hsa-miR-4708-5p tgaaacccCATCTCTacta
 0 AGAGAUGC m7a Disrupted NA NA 0.01
hsa-miR-483-5p tgaaacCCCGTCTctacta
 0 AAGACGGG m7b Created no TS -0.237 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.35872121A>G ICGC_69D551B6-2A78-11E2-9E37-02FD496BB9B8 CPCG_0099_Pr_P_P1 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-197-3p gccaacaTGGTGAAacccc
 0 UUCACCAC m7a Created no TS -0.096 No effect
hsa-miR-4716-5p gccAACATGGtgaaacccc
 0 UCCAUGUU m7b (m6c->m7b) no TS -0.043 No effect
hsa-miR-5096 gccaacatGGTGAAACccc
 0 GUUUCACC m8a Created no TS -0.15 -3.59
hsa-miR-96-3p gccaACATGATgaaacccc
 0 AAUCAUGU m7b Disrupted -0.111 no TS 2.42


Mutation Mutation ID Sample Name Cancer Type
chr17:g.35872142G>A ICGC_8C3E63BE-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.35872143C>T ICGC_AF935DE2-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-371a-5p tcaggaGTTTGAGaccagc
 0 ACUCAAAC m7b Created no TS -0.112 -1.72
hsa-miR-371b-5p tcaggagTTTGAGaccagc
 0 ACUCAAAA m6b Created no TS 0.034 -4.23
hsa-miR-373-5p tcaggagTTTGAGaccagc
 0 ACUCAAAA m6b Created no TS 0.034 -4.71
hsa-miR-616-5p tcaggagTTTGAGaccagc
 0 ACUCAAAA m6b Created no TS 0.027 -6.13

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
35871567 rs180681504 - G hsa-miR-3672
hsa-miR-6864-3p
0 tccgccGTCTCAA
tccgccGTCTCAA
 Unknown
Unknown
N
N
 -0.067
-0.067
A hsa-miR-1273f
hsa-miR-143-3p
hsa-miR-25-5p
hsa-miR-4708-5p
hsa-miR-4730
hsa-miR-4770
hsa-miR-6088
0 tccgCCATCTCAa
tccgcCATCTCAa
TCCGCCAtctcaa
tccgcCATCTCAa
TCCGCCAtctcaa
tccgcCATCTCAa
tccgcCATCTCAa
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
 -0.258
-0.067
-0.231
-0.075
-0.328
-0.074
-0.07
35871589 rs1065341 - A hsa-miR-143-5p
hsa-miR-4255
hsa-miR-4326
hsa-miR-6499-3p
0 aggaacACTGCAC
agGAACACTgcac
AGGAACActgcac
aggaACACTGCAc
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 -0.15
-0.045
-0.184
-0.288
G hsa-miR-3944-5p
0 aggaacGCTGCAC
 Unknown
N
 -0.189
35871982 rs1143512 - G hsa-miR-4634
hsa-miR-5693
0 gaTCGCGCCActg
gatcgcGCCACTG
 Unknown
Unknown
N
N
 -0.515
-0.06
A hsa-miR-4466
hsa-miR-675-5p
0 gatCGCACCActg
gatCGCACCActg
 Unknown
Unknown
N
N
 -0.177
-0.177
35872107 rs1142896 - C hsa-miR-1273f
hsa-miR-411-5p
hsa-miR-6832-5p
1
0
1
 CCATCTCtactaa
ccatcTCTACTAa
ccaTCTCTACtaa
 Unknown
Unknown
Unknown
N
N
N
 -0.166
-0.098
-0.19
G hsa-miR-5683
1
 cCATCTGTActaa
 Unknown
N
 -0.221
35872109 rs1142895 - C hsa-miR-1273f
hsa-miR-6832-5p
1
1
 ccCCATCTCtact
ccccaTCTCTACt
 Unknown
Unknown
N
N
 -0.166
-0.19
G hsa-miR-411-5p
1
 ccccatGTCTACT
 Unknown
N
 -0.22
35872123 rs41446448 - T hsa-miR-4781-3p
hsa-miR-96-3p
1
1
 CCAACATgatgaa
ccaACATGATgaa
 Unknown
Unknown
N
N
 -0.071
-0.111

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