SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_182511
Gene Symbol: CBLN2
Description: Homo sapiens cerebellin 2 precursor (CBLN2), mRNA.
Gene Location: chr18(-):70203914-70211723
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr18:g.72536923A>T COSN1756360 RK052_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537077G>T COSN4776316 tumor_4176133 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537113G>T ICGC_BC9257F0-2A78-11E2-9C69-1CFD496BB9B8 CPCG_0103_Pr_P_P3 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537487A>T COSN8604777 J54_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-5p tcccTCCTCAaccccactt
 5
 GUGAGGAC m6b Disrupted -0.049000 no TS No effect
hsa-miR-193b-5p tccctcctcAACCCCactt
 2
 CGGGGUUU m6b Disrupted -0.107000 no TS 0.010000
hsa-miR-197-5p tccctccTCTACCCcactt
 0 CGGGUAGA m7b Created no TS -0.125000 -0.120000
hsa-miR-3132 tccctccTCTACCCcactt
 0 UGGGUAGA m7b Created no TS -0.144000 No effect
hsa-miR-3150b-3p tccCTCCTCAaccccactt
 8
 UGAGGAGA m7a (m7a->m6b) -0.067000 no TS No effect
hsa-miR-3170 tccctcctcAACCCCActt
 2
 CUGGGGUU m7b (m7b->m6b) -0.106000 no TS No effect
hsa-miR-3916 tcccTCCTCTaccccactt
 0 AAGAGGAA m6b Created no TS -0.025000 No effect
hsa-miR-4451 tccctcCTCTACCccactt
 0 UGGUAGAG m7b Created no TS -0.095000 0.010000
hsa-miR-4689 tccCTCCTCAAccccactt
 5
 UUGAGGAG m8a Disrupted -0.146000 no TS 0.080000
hsa-miR-4784 tccCTCCTCAaccccactt
 8
 UGAGGAGA m7a (m7a->m6b) -0.060000 no TS -1.360000
hsa-miR-877-5p tcccTCCTCTACcccactt
 11
 GUAGAGGA m8a Created -0.132000 -0.156000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537609C>T COSN1756361 RK066_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-526b-5p ggaacctgTCAAGAagtgc
 17
 CUCUUGAG m6b Disrupted -0.015000 no TS No effect
hsa-miR-552 ggaACCTGTTaagaagtgc
 4
 AACAGGUG m7a (m6b->m7a) -0.109000 -0.109000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537649G>T COSN8604778 4472_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2116-3p catgtggcTGGGAGGactt
 0 CCUCCCAU m7a Disrupted NA NA -1.930000
hsa-miR-449b-3p caTGTGGCTGggaggactt
 1
 CAGCCACA m8a (m8a->m7b) -0.057000 -0.084000 No effect
hsa-miR-4691-3p catGTGGCTGGgaggactt
 1
 CCAGCCAC m8a Disrupted -0.123000 no TS 6.310000
hsa-miR-4691-5p catgtggctTGGAGGACtt
 0 GUCCUCCA m8a (m7a->m8a) no TS -0.123000 -5.290000
hsa-miR-532-3p catgtggcTGGGAGGactt
 0 CCUCCCAC m7a Disrupted NA NA -1.440000
hsa-miR-5695 catgtggCTTGGAGgactt
 0 ACUCCAAG m7b Created no TS -0.029000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537650T>A COSN9343880 AOCS-139-12-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2116-3p ccatgtggcTGGGAGGact
 0 CCUCCCAU m7a (m7a->m6a) NA NA -0.350000
hsa-miR-3064-3p ccaTGTGGCAgggaggact
 0 UUGCCACA m7b (m6c->m7b) no TS -0.071000 4.200000
hsa-miR-449b-3p ccaTGTGGCTGggaggact
 1
 CAGCCACA m8a Disrupted -0.057000 no TS No effect
hsa-miR-4691-3p ccatGTGGCTGGgaggact
 1
 CCAGCCAC m8a Disrupted -0.123000 no TS 6.310000
hsa-miR-4722-3p ccatgTGGCAGGgaggact
 0 ACCUGCCA m7b Created no TS -0.077000 0.100000
hsa-miR-532-3p ccatgtggcTGGGAGGact
 0 CCUCCCAC m7a (m7a->m6a) NA NA -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537829C>T COSN4965794 SS6003308 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1468 tcgtcccAACGGAaggaga
 0 CUCCGUUU m6b Disrupted -0.110000 no TS No effect
hsa-miR-3122 tcGTCCCAACggaaggaga
 3
 GUUGGGAC m8a (m8a->m7b) -0.227000 -0.254000 -1.980000
hsa-miR-4425 tcgTCCCAACggaaggaga
 0 UGUUGGGA m7b (m7b->m6c) -0.115000 no TS 0.190000
hsa-miR-1468 tcgtcccAACGGAaggaga
 0 CUCCGUUU m6b Disrupted -0.110000 no TS No effect
hsa-miR-3122 tcGTCCCAACggaaggaga
 3
 GUUGGGAC m8a (m8a->m7b) -0.227000 -0.254000 -1.980000
hsa-miR-4425 tcgTCCCAACggaaggaga
 0 UGUUGGGA m7b (m7b->m6c) -0.115000 no TS 0.190000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.72537842A>G COSN6134265 RK212_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5003-5p gtaTGTTGTGttgtcgtcc
 0 UCACAACA m7b (m6c->m7b) no TS -0.151000 -5.850000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
72537836 rs145307033 G G hsa-miR-1302
hsa-miR-3122
hsa-miR-3913-5p
hsa-miR-4298
hsa-miR-92b-5p
3
3
3
3
1
 attgtcGTCCCAA
attgtcGTCCCAA
attgtcGTCCCAA
attgtcGTCCCAA
attgtCGTCCCAa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.14
-0.099
-0.081
-0.133
-0.206
A hsa-miR-450b-3p
hsa-miR-5089-5p
hsa-miR-5187-5p
hsa-miR-6513-5p
hsa-miR-6728-5p
hsa-miR-6744-5p
hsa-miR-769-3p
3
3
1
3
1
3
3
 attgtcATCCCAA
attgtcATCCCAA
attgTCATCCCAa
attgtcATCCCAA
attgtCATCCCAA
attGTCATCCcaa
attgtcATCCCAA
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.108
-0.079
-0.306
-0.071
-0.316
-0.177
-0.094

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