SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_031448
Gene Symbol: C19orf12
Description: Homo sapiens chromosome 19 open reading frame 12 (C19orf12), transcript variant 1, mRNA.
Gene Location: chr19(-):30189792-30206452
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr19:g.29699033T>C COSN5850745 HX31T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3622a-5p gcctaaccaCGTGCCTGgt
 2
 CAGGCACG m8a (m7a->m8a) -0.183000 -0.420000 -2.080000
hsa-miR-4717-3p gcctaaCCATGTGcctggt
 2
 ACACAUGG m7b Disrupted -0.161000 0.026000 0.660000
hsa-miR-5582-5p gcctaaccaTGTGCCTggt
 2
 UAGGCACA m7b (m7b->m6b) -0.559000 -0.357000 0.460000
hsa-miR-5589-3p gcctaacCATGTGCctggt
 2
 UGCACAUG m7b Disrupted -0.450000 -0.304000 1.020000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29699190C>T COSN14988474 SM-4AX85 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1295a cactgcgccCGGCCTAtgt
 1
 UUAGGCCG m7b (m7b->m6b) -0.340000 -0.118000 -0.190000
hsa-miR-15a-3p cactgcgccTGGCCTatgt
 0 CAGGCCAU m6b Created no TS -0.158000 No effect
hsa-miR-4755-3p cactgcGCCTGGCctatgt
 3
 AGCCAGGC m7b Created -0.007000 -0.196000 No effect
hsa-miR-5704 cactgcgccTGGCCTAtgt
 2
 UUAGGCCA m7b (m6b->m7b) -0.100000 -0.271000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr19:g.29699868A>G COSN1765034 RK075_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr19:g.29700097A>T COSN6141637 RK183_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-188-5p ctgcAGGGATaaatgccca
 0 CAUCCCUU m6b Created no TS -0.013000 -12.020000
hsa-miR-4446-5p ctgcAGGGAAAaatgccca
 1
 AUUUCCCU m7b Disrupted 0.114000 no TS 0.660000
hsa-miR-4729 ctgcagggATAAATGccca
 0 UCAUUUAU m7b Created 0.161000 0.430000 -3.790000
hsa-miR-4755-5p ctgcAGGGAAAaatgccca
 1
 UUUCCCUU m7a Disrupted 0.132000 0.088000 0.310000
hsa-miR-5006-3p ctgcAGGGAAAaatgccca
 1
 UUUCCCUU m7a Disrupted 0.142000 0.098000 0.110000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29700528T>G COSN6141638 RK119_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1286 ttcctgctcGTCCTGCAaa
 2
 UGCAGGAC m8a (m7a->m8a) -0.288000 -0.349000 -0.100000
hsa-miR-2278 ttcCTGCTCTtcctgcaaa
 4
 GAGAGCAG m7b (m7b->m6c) 0.023000 no TS No effect
hsa-miR-4436a ttcctgctcGTCCTGCaaa
 0 GCAGGACA m7a (m6a->m7a) NA NA -0.070000
hsa-miR-873-5p ttcctgctcTTCCTGCaaa
 0 GCAGGAAC m7a (m7a->m6a) NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29700678C>G COSN9848537 C0054T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1914-5p gtgccctaGCACAGGccac
 3
 CCCUGUGC m7b Disrupted -0.012000 no TS -0.110000
hsa-miR-214-5p gtgccctagGACAGGCcac
 0 UGCCUGUC m7b (m6b->m7b) no TS 0.024000 0.140000
hsa-miR-5008-3p gtgccctAGCACAGGccac
 2
 CCUGUGCU m8a Disrupted 0.030000 no TS 0.040000
hsa-miR-5571-3p gtgcCCTAGGACaggccac
 0 GUCCUAGG m8a Created no TS 0.048000 No effect
hsa-miR-676-3p gtgcccTAGGACAGgccac
 0 CUGUCCUA m8a Created no TS 0.132000 -1.890000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29701734C>T COSN1765035 RK066_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 atagactTGTCTGatgcca
 1
 CCAGACAG m6b Created 0.113000 0.100000 -2.880000
hsa-miR-4269 atagactTGCCTGatgcca
 2
 GCAGGCAC m6b Disrupted -0.282000 -0.240000 No effect
hsa-miR-4514 atagactTGCCTGatgcca
 0 ACAGGCAG m6b Disrupted -0.190000 -0.160000 No effect
hsa-miR-4742-5p atagacTTGCCTGAtgcca
 2
 UCAGGCAA m8a Disrupted -0.145000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29701743A>G COSN1765036 RK086_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1271-5p tgGTGCCAAGtagacttgc
 1
 CUUGGCAC m8a (m7b->m8a) -0.162000 -0.068000 1.070000
hsa-miR-138-1-3p tggtgccAAGTAGacttgc
 0 GCUACUUC m6b Created no TS 0.036000 No effect
hsa-miR-138-2-3p tggtgccAAATAGacttgc
 1
 GCUAUUUC m6b Disrupted 0.112000 no TS 0.010000
hsa-miR-5002-5p tggtgCCAAATagacttgc
 1
 AAUUUGGU m6b Disrupted 0.062000 no TS 0.070000
hsa-miR-934 tggtgccaAGTAGACttgc
 0 UGUCUACU m7b Created no TS -0.058000 0.210000
hsa-miR-96-5p tgGTGCCAAAtagacttgc
 1
 UUUGGCAC m8a (m8a->m7b) -0.172000 -0.077000 2.900000
hsa-miR-1271-5p tgGTGCCAAGtagacttgc
 0 CUUGGCAC m8a (m7b->m8a) -0.162 -0.068 1.07
hsa-miR-138-1-3p tggtgccAAGTAGacttgc
 0 GCUACUUC m6b Created no TS 0.036 No effect
hsa-miR-138-2-3p tggtgccAAATAGacttgc
 0 GCUAUUUC m6b Disrupted 0.112 no TS 0.01
hsa-miR-5002-5p tggtgCCAAATagacttgc
 0 AAUUUGGU m6b Disrupted 0.062 no TS 0.07
hsa-miR-934 tggtgccaAGTAGACttgc
 0 UGUCUACU m7b Created no TS -0.058 0.21
hsa-miR-96-5p tgGTGCCAAAtagacttgc
 0 UUUGGCAC m8a (m8a->m7b) -0.172 -0.077 2.9


Mutation Mutation ID Sample Name Cancer Type
chr19:g.29701756A>G COSN15263066 LP6007520-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr19:g.29702430G>A COSN4967337 SS6003113 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-127-5p gcagGCTTCAGaggcgtct
 3
 CUGAAGCU m7a Created 0.035000 0.035000 No effect
hsa-miR-1281 gcaggcttcGGAGGCGtct
 0 UCGCCUCC m7b (m7b->m6b) -0.219000 no TS No effect
hsa-miR-146a-3p gcaggcTTCAGAGGcgtct
 0 CCUCUGAA m8a Created -0.030000 0.004000 No effect
hsa-miR-4671-5p gcaggCTTCGGaggcgtct
 0 ACCGAAGA m6b Disrupted -0.137000 no TS 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.29702628C>T COSN15316590 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-3p gaagccCAGTGGatgcccc
 0 ACCACUGC m6b Created no TS -0.088000 No effect
hsa-miR-181a-2-3p gaagccCAGTGGatgcccc
 0 ACCACUGA m6b Created no TS -0.100000 No effect
hsa-miR-378g gaAGCCCAGTggatgcccc
 3
 ACUGGGCU m8a (m7b->m8a) -0.163000 -0.191000 No effect
hsa-miR-1273g-3p gaagccCAGTGGatgcccc
 0 ACCACUGC m6b Created no TS -0.088000 No effect
hsa-miR-181a-2-3p gaagccCAGTGGatgcccc
 0 ACCACUGA m6b Created no TS -0.100000 No effect
hsa-miR-378g gaAGCCCAGTggatgcccc
 3
 ACUGGGCU m8a (m7b->m8a) -0.163000 -0.191000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
29699340 rs117537955 C C hsa-miR-4253
hsa-miR-6862-5p
1
1
 CATGCCCggctaa
CATGCCCggctaa
 Disrupted
Disrupted
N
N
 -0.156
-0.137
T hsa-miR-4645-5p
hsa-miR-4662a-5p
hsa-miR-4673
hsa-miR-4676-5p
hsa-miR-4755-3p
hsa-miR-575
hsa-miR-6858-3p
1
2
1
1
1
1
1
 caTGCCTGGctaa
catgccTGGCTAA
caTGCCTGGctaa
catgcCTGGCTAa
catGCCTGGCtaa
catgcCTGGCTAa
catgcCTGGCTAa
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.167
-0.128
-0.223
-0.154
-0.297
-0.154
-0.145
29699806 rs111907753 G G hsa-miR-1911-3p
hsa-miR-4514
hsa-miR-4645-5p
hsa-miR-4673
hsa-miR-4692
hsa-miR-6753-5p
2
2
2
2
2
2
 ctGCCTGGTAcaa
CTGCCTGgtacaa
cTGCCTGGtacaa
cTGCCTGGtacaa
CTGCCTGgtacaa
ctgCCTGGTAcaa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.32
-0.119
-0.164
-0.136
-0.138
-0.106
C hsa-miR-1827
2
 CTGCCTCgtacaa
 Created
N
 -0.134
29700050 rs78094750 T C hsa-miR-181a-3p
hsa-miR-5188
4
4
 tgtgtcCGATGGA
tgtGTCCGATgga
 Created
Created
N
N
 -0.093
-0.163
T hsa-miR-1324
hsa-miR-6884-3p
4
4
 tgTGTCTGAtgga
tgtgtcTGATGGA
 Disrupted
Disrupted
N
N
 0.012
0.024
29700526 rs73548135 C C hsa-miR-1286
hsa-miR-4722-5p
hsa-miR-6077
hsa-miR-6511b-5p
hsa-miR-6811-5p
1
1
3
1
1
 gctctTCCTGCAa
gctctTCCTGCAa
gCTCTTCCtgcaa
gctcttCCTGCAA
gctcttCCTGCAA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.016
0.015
0.078
-0.021
-0.018
T hsa-miR-1273h-3p
hsa-miR-1276
hsa-miR-298
hsa-miR-3678-3p
1
3
1
1
 gctcttTCTGCAA
GCTCTTTctgcaa
gctctTTCTGCAa
gctcttTCTGCAA
 Created
Created
Created
Created
N
N
N
N
 0.016
0.056
0.045
0.019
29701176 rs182215624 T T hsa-miR-4729
5
 aATAAATGttttt
 Disrupted
N
 0.105
C hsa-miR-424-3p
2
 aataaACGTTTTt
 Created
N
 -0.004
29701351 rs189239161 C
T hsa-miR-5589-3p
0 aggttATGTGCAa
 Created
N
 0.007
29701985 rs143608870 G
A hsa-miR-146a-3p
hsa-miR-301a-5p
hsa-miR-3675-3p
hsa-miR-3921
hsa-miR-4251
hsa-miR-4329
hsa-miR-4653-5p
hsa-miR-6761-5p
1
1
1
1
2
2
1
2
 tatcTCAGAGAta
tatcTCAGAGAta
tatctcAGAGATA
tatCTCAGAGAta
taTCTCAGAgata
taTCTCAGAgata
tatCTCAGAGAta
taTCTCAGAgata
 Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
 -0.072
-0.083
-0.038
-0.276
-0.053
-0.062
-0.255
-0.056
29702424 rs180882102 G G hsa-miR-1281
1
 GGAGGCGtctgct
 Disrupted
N
 -0.219
A hsa-miR-6778-3p
hsa-miR-6791-3p
hsa-miR-6829-3p
hsa-miR-6836-3p
1
1
1
1
 GGAGGCAtctgct
GGAGGCAtctgct
GGAGGCAtctgct
GGAGGCAtctgct
 Created
Created
Created
Created
N
N
N
N
 -0.129
-0.156
-0.153
-0.171
29702431 rs140718921 C C hsa-miR-4671-5p
1
 aggCTTCGGAggc
 Disrupted
N
 -0.137
T hsa-miR-519d-5p
1
 aggcTTTGGAGgc
 Created
N
 0.013
29702628 rs117867574 C
T hsa-miR-1273g-3p
hsa-miR-181a-2-3p
hsa-miR-6509-3p
1
1
1
 gccCAGTGGAtgc
gccCAGTGGAtgc
gccCAGTGGAtgc
 Created
Created
Created
N
N
N
 -0.088
-0.1
-0.092

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