SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_032043
Gene Symbol:	BRIP1
Description:	Homo sapiens BRCA1 interacting protein C-terminal helicase 1 (BRIP1), mRNA.
Gene Location:	chr17(-):59756546-59940920
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61680768G>A			COSN15357206		AOCS-034-3-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273g-3p	gccaggcGCAGTGGctcac	2	ACCACUGC	m7b	Created	-0.278000	-0.218000	No effect
hsa-miR-4252	gccaggcgCAGTGGCtcac	0	GGCCACUG	m7b	Created	-0.218000	-0.155000	-2.240000
hsa-miR-1273g-3p	gccaggcGCAGTGGctcac	2	ACCACUGC	m7b	Created	-0.278000	-0.218000	No effect
hsa-miR-4252	gccaggcgCAGTGGCtcac	0	GGCCACUG	m7b	Created	-0.218000	-0.155000	-2.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61680826G>A			COSN8244846		PCSI_0084_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4289	tttattttCACAATGCtac	3	GCAUUGUG	m8a	Created	-0.071000	-0.139000	-0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61681331C>A			COSN5418875		RK298_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4431	attctGAGTCGattttcat	0	GCGACUCU	m6b	Disrupted	-0.114000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61681902T>C			COSN6108687		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1295b-3p	tctgtatGGCCTATTattt	0	AAUAGGCC	m8a	Created	no TS	-0.173000	-0.240000
hsa-miR-15a-3p	tctgtATGGCCTattattt	2	CAGGCCAU	m7b	Created	-0.112000	-0.288000	-0.160000
hsa-miR-4529-5p	tctgtATGGCCTattattt	0	AGGCCAUC	m7a	Created	NA	NA	-2.000000
hsa-miR-5704	tctgtaTGGCCTAttattt	2	UUAGGCCA	m7b	Created	-0.118000	-0.292000	-0.050000
hsa-miR-591	tctgtATGGTCTattattt	0	AGACCAUG	m7a	Disrupted	NA	NA	5.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61682900C>G			COSN7441834		8012211		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1827	tgcccttctCTGCCTCcct	2	UGAGGCAG	m7b	(m7b->m6b)	-0.464000	-0.342000	-0.240000
hsa-miR-3154	tgCCCTTCTGtgcctccct	2	CAGAAGGG	m8a	(m7b->m8a)	-0.073000	-0.073000	No effect
hsa-miR-3919	tgcccTTCTCTGCctccct	2	GCAGAGAA	m8a	Disrupted	0.060000	0.032000	No effect
hsa-miR-5582-5p	tgcccttcTGTGCCTccct	0	UAGGCACA	m7b	Created	no TS	-0.101000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.61683215G>A			BRIP1_E20_UTR_3		SJHYPO009_D		Hypodiploid_ALL
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-32-3p	ttgTAAATTGaataagtgg	0	CAAUUUAG	m7a	(m7a->m6b)	0.218	0.209	No effect
hsa-miR-4272	ttgtaaaTTGAATaagtgg	0	CAUUCAAC	m6b	Disrupted	-0.069	no TS	No effect
hsa-miR-4775	ttgtAAATTAAataagtgg	0	UUAAUUUU	m7a	Created	1.037	1.068	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
61679705	rs73326602	A	A	hsa-miR-452-3p	1	tagtAGATGAAtc	Disrupted	N	-0.059
			T	hsa-miR-4272 hsa-miR-606	1 1	tagtaGTTGAATc tAGTAGTTgaatc	Created Created	N N	-0.128 -0.172
61681332	rs140267868	T	T	hsa-miR-4431	8	tctGAGTCGAttt	Disrupted	N	-0.114
			C	hsa-miR-24-3p hsa-miR-6741-3p	8 8	tCTGAGCCgattt tctGAGCCGAttt	Created Created	N N	-0.106 -0.121
61682680	rs116292412	A	A	hsa-miR-4775 hsa-miR-590-3p	4 4	acataAAAATTAA acataAAAATTAa	Disrupted Disrupted	N N	0.108 0.121
			G	hsa-miR-5571-5p	4	acataAGAATTAa	Created	N	0.028

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