SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006768
Gene Symbol: BRAP
Description: Homo sapiens BRCA1 associated protein (BRAP), mRNA.
Gene Location: chr12(-):112079949-112123790
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.111642673A>G COSN8694855 AOCS-168-1-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-5p cataacctAGTTCTCtttc
 0 UGAGAACU m7b Created no TS -0.160000 -1.240000
hsa-miR-146b-5p cataacctAGTTCTCtttc
 0 UGAGAACU m7b Created no TS -0.151000 -1.630000
hsa-miR-3123 cataacctaATTCTCTttc
 8
 CAGAGAAU m7b (m7b->m6b) -0.124000 no TS 0.360000
hsa-miR-3925-5p cataacctaGTTCTCTTtc
 0 AAGAGAAC m8a (m7a->m8a) no TS -0.153000 -1.600000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.111642975T>C COSN8694856 AOCS-091-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-142-5p tttgCTTTATaattagcca
 6
 CAUAAAGU m6b Disrupted 0.039000 no TS 1.180000
hsa-miR-340-5p tttgCTTTATAAttagcca
 6
 UUAUAAAG m8a Disrupted 0.195000 0.128000 3.110000
hsa-miR-5590-3p tttgCTTTATaattagcca
 6
 AAUAAAGU m6b Disrupted 0.039000 no TS No effect
hsa-miR-9-3p tttGCTTTATaattagcca
 0 AUAAAGCU m7a (m7a->m6b) -0.008000 -0.008000 0.320000
hsa-miR-944 tttgctttATAATTagcca
 8
 AAAUUAUU m6b Disrupted 0.176000 0.048000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.111643428G>T COSN10097729 C0025T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3921 caaatCTCAGAGtgggtat
 7
 UCUCUGAG m7b Disrupted -0.097000 no TS 1.040000
hsa-miR-4251 caaaTCTCAGagtgggtat
 7
 CCUGAGAA m6b Disrupted -0.012000 no TS 0.060000
hsa-miR-4301 caaatctcaTAGTGGGtat
 6
 UCCCACUA m7b (m6b->m7b) -0.171000 -0.339000 0.110000
hsa-miR-4329 caaaTCTCAGagtgggtat
 7
 CCUGAGAC m6b Disrupted -0.038000 no TS 0.430000
hsa-miR-4653-5p caaatCTCAGAGtgggtat
 7
 UCUCUGAG m7b Disrupted -0.106000 no TS No effect
hsa-miR-4712-3p caaaTCTCATagtgggtat
 0 AAUGAGAG m6b Created no TS -0.012000 0.030000
hsa-miR-4714-5p caaatcTCAGAGTgggtat
 6
 AACUCUGA m7b Disrupted -0.044000 no TS 1.980000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.111643700A>G COSN8288766 ASHPC_0009_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3682-3p catatcatTATCATCtccc
 2
 UGAUGAUA m7b Disrupted -0.085000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.111644043G>C COSN195797 PD4199a [NS][NS][NS][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p tgatgtagTGAATGTaaag
 9
 AACAUUCA m7b Disrupted -0.400000 -0.221000 3.050000
hsa-miR-181b-5p tgatgtagTGAATGTaaag
 9
 AACAUUCA m7b Disrupted -0.400000 -0.221000 1.550000
hsa-miR-181c-5p tgatgtagTGAATGTaaag
 9
 AACAUUCA m7b Disrupted -0.393000 -0.214000 0.470000
hsa-miR-181d tgatgtagTGAATGTaaag
 9
 AACAUUCA m7b Disrupted -0.411000 -0.232000 0.040000
hsa-miR-4262 tgatgtagTGAATGTaaag
 9
 GACAUUCA m7b Disrupted -0.414000 -0.214000 0.060000
hsa-miR-4999-3p tgatGTAGTGAatgtaaag
 3
 UCACUACC m7a Disrupted -0.147000 no TS No effect
hsa-miR-181a-5p tgatgtagTGAATGTaaag
 0 AACAUUCA m7b Disrupted -0.4 -0.221 3.05
hsa-miR-181b-5p tgatgtagTGAATGTaaag
 0 AACAUUCA m7b Disrupted -0.4 -0.221 1.55
hsa-miR-181c-5p tgatgtagTGAATGTaaag
 0 AACAUUCA m7b Disrupted -0.393 -0.214 0.47
hsa-miR-181d tgatgtagTGAATGTaaag
 0 AACAUUCA m7b Disrupted -0.411 -0.232 0.04
hsa-miR-4262 tgatgtagTGAATGTaaag
 0 GACAUUCA m7b Disrupted -0.414 -0.214 0.06
hsa-miR-4999-3p tgatGTAGTGAatgtaaag
 0 UCACUACC m7a Disrupted -0.147 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.111644163C>T COSN1142155 BN04T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1321 actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.114000 -0.114000 No effect
hsa-miR-211-3p actgttcTCCCTGacactg
 3
 GCAGGGAC m6b Disrupted -0.290000 -0.143000 5.560000
hsa-miR-3925-5p actGTTCTCTctgacactg
 0 AAGAGAAC m7b (m6c->m7b) no TS -0.132000 No effect
hsa-miR-4270 actgttCTCCCTGAcactg
 2
 UCAGGGAG m8a Disrupted -0.540000 -0.134000 4.380000
hsa-miR-4441 actgttCTCCCTGacactg
 2
 ACAGGGAG m7b Disrupted -0.539000 -0.144000 1.630000
hsa-miR-4756-3p actgttcTCTCTGacactg
 3
 CCAGAGAU m6b Created -0.053000 -0.152000 0.750000
hsa-miR-4756-5p actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.127000 -0.127000 0.430000
hsa-miR-1321 actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.114000 -0.114000 No effect
hsa-miR-211-3p actgttcTCCCTGacactg
 3
 GCAGGGAC m6b Disrupted -0.290000 -0.143000 5.560000
hsa-miR-3925-5p actGTTCTCTctgacactg
 0 AAGAGAAC m7b (m6c->m7b) no TS -0.132000 No effect
hsa-miR-4270 actgttCTCCCTGAcactg
 2
 UCAGGGAG m8a Disrupted -0.540000 -0.134000 4.380000
hsa-miR-4441 actgttCTCCCTGacactg
 2
 ACAGGGAG m7b Disrupted -0.539000 -0.144000 1.630000
hsa-miR-4756-3p actgttcTCTCTGacactg
 3
 CCAGAGAU m6b Created -0.053000 -0.152000 0.750000
hsa-miR-4756-5p actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.127000 -0.127000 0.430000
hsa-miR-1321 actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.114 -0.114 No effect
hsa-miR-211-3p actgttcTCCCTGacactg
 0 GCAGGGAC m6b Disrupted -0.29 -0.143 5.56
hsa-miR-3925-5p actGTTCTCTctgacactg
 0 AAGAGAAC m7b (m6c->m7b) no TS -0.132 No effect
hsa-miR-4270 actgttCTCCCTGAcactg
 0 UCAGGGAG m8a Disrupted -0.54 -0.134 4.38
hsa-miR-4441 actgttCTCCCTGacactg
 0 ACAGGGAG m7b Disrupted -0.539 -0.144 1.63
hsa-miR-4756-3p actgttcTCTCTGacactg
 0 CCAGAGAU m6b Created -0.053 -0.152 0.75
hsa-miR-4756-5p actgttCTCCCTGacactg
 0 CAGGGAGG m7a Disrupted -0.127 -0.127 0.43

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
111642242 rs142187177 C C hsa-miR-3120-5p
hsa-miR-3182
hsa-miR-4743-3p
hsa-miR-6888-3p
2
2
3
3
 atCAGACAGAagt
atcagACAGAAGt
atcaGACAGAAgt
atcAGACAGAAgt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.399
-0.154
-0.174
-0.333
G hsa-miR-146a-3p
hsa-miR-301a-5p
hsa-miR-3921
hsa-miR-4653-5p
hsa-miR-4768-5p
hsa-miR-6817-3p
hsa-miR-6833-3p
hsa-miR-6873-3p
hsa-miR-7110-3p
hsa-miR-942-5p
2
2
2
2
3
2
3
3
3
2
 aTCAGAGAgaagt
aTCAGAGAgaagt
aTCAGAGAgaagt
aTCAGAGAgaagt
atcaGAGAGAAgt
atCAGAGAGAagt
atcaGAGAGAAgt
atcAGAGAGAAgt
atcAGAGAGAagt
atcagAGAGAAGt
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 -0.113
-0.128
-0.111
-0.111
-0.164
-0.385
-0.155
-0.287
-0.135
-0.152
111643098 rs59185961 C T hsa-miR-340-5p
21
 ataaTTTATAAcc
 Created
N
 0.128
C hsa-miR-183-3p
7
 aTAATTCAtaacc
 Disrupted
N
 0.003
111643625 rs2339821 G G hsa-miR-2861
hsa-miR-3918
hsa-miR-4512
hsa-miR-4685-5p
hsa-miR-6837-5p
1
2
1
3
3
 aacCAGGCCCtgg
aaccaGGCCCTGg
aaccAGGCCCTgg
aaccagGCCCTGG
aaccagGCCCTGG
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.162
-0.175
-0.136
-0.159
-0.15
T hsa-miR-211-3p
hsa-miR-3199
hsa-miR-4515
hsa-miR-7113-5p
hsa-miR-8052
2
1
1
3
1
 aaccaGTCCCTGg
aacCAGTCCCtgg
aaCCAGTCCctgg
aaccagTCCCTGG
aacCAGTCCCtgg
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.117
-0.145
-0.19
-0.129
-0.136

Genome Browser