SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001202
Gene Symbol:	BMP4
Description:	Homo sapiens bone morphogenetic protein 4 (BMP4), transcript variant 1, mRNA.
Gene Location:	chr14(-):54416454-54423554
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.53949847A>G			COSN6637747		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-224-5p	accttatttGTGACTTtac	32767	CAAGUCAC	m7b	(m6b->m7b)	no TS	-0.242000	-2.180000
hsa-miR-4719	accttATTTGTGActttac	32767	UCACAAAU	m8a	Created	no TS	-0.198000	-1.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.53949884A>T			COSN15565142		C0010T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-587	aaaaaaaaATGGAAAaaat	32767	UUUCCAUA	m7a	Created	no TS	-0.101000	-7.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.53949885A>T			COSN7021582		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-202-5p	aaaaaaaaATAGGAAaaaa	32767	UUCCUAUG	m7a	Created	no TS	-0.151000	-2.600000
hsa-miR-337-3p	aaaaaaaaATAGGAaaaaa	32767	CUCCUAUA	m6b	Created	no TS	-0.155000	-2.500000
hsa-miR-3685	aaaaaaaaaTAGGAAAaaa	32767	UUUCCUAC	m7a	(m6a->m7a)	no TS	-0.119000	-2.610000
hsa-miR-384	aaaaaaaaaTAGGAAaaaa	32767	AUUCCUAG	m6b	Created	no TS	-0.131000	-4.280000
hsa-miR-202-5p	aaaaaaaaATAGGAAaaaa	32767	UUCCUAUG	m7a	Created	no TS	-0.151000	-2.600000
hsa-miR-337-3p	aaaaaaaaATAGGAaaaaa	32767	CUCCUAUA	m6b	Created	no TS	-0.155000	-2.500000
hsa-miR-3685	aaaaaaaaaTAGGAAAaaa	32767	UUUCCUAC	m7a	(m6a->m7a)	no TS	-0.119000	-2.610000
hsa-miR-384	aaaaaaaaaTAGGAAaaaa	32767	AUUCCUAG	m6b	Created	no TS	-0.131000	-4.280000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.53949902T>A			COSN6411862		HX18T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5692a	acttTTATTTaaaaaaaaa	32767	CAAAUAAU	m6b	Disrupted	0.092000	0.052000	0.150000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.53949910C>A			COSN6253810		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	atagctggaATTTTATtta	32767	UAUAAAAU	m7b	(m6b->m7b)	no TS	-0.042000	-0.410000
hsa-miR-548n	atagctggACTTTTattta	32767	CAAAAGUA	m6b	Disrupted	-0.017000	no TS	0.020000
hsa-miR-548t-5p	atagctggACTTTTattta	32767	CAAAAGUG	m6b	Disrupted	-0.015000	no TS	0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
53949884	rs76335800	-
			T	hsa-miR-153-5p hsa-miR-587	0	aAAAAATGgaaaa aaaaaATGGAAAa	Unknown Unknown	N N	-0.091 -0.101
53949901	rs76149166	-	A	hsa-miR-5692a	0	TTATTTAaaaaaa	Unknown	N	0.04
53949904	rs61983162	T	T	hsa-miR-5692a	0	cttTTATTTAaaa	Disrupted	N	0.04

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