SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001168
Gene Symbol:	BIRC5
Description:	Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2, mRNA.
Gene Location:	chr17(+):76210276-76221716
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78223612C>T			ICGC_1428647		TCGA-D1-A17Q-01A-11D-A12J-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78223653C>A			ICGC_1428648		TCGA-D1-A17Q-01A-11D-A12J-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3617	tagcaATGTCTTaggaaag	0	AAAGACAU	m7b	Disrupted	-0.205	no TS	1.15
hsa-miR-374c-5p	tagcaaTGTATTAggaaag	0	AUAAUACA	m7b	Created	no TS	-0.131	-0.56
hsa-miR-641	tagcaATGTCTTaggaaag	0	AAAGACAU	m7b	Disrupted	-0.194	no TS	1.58
hsa-miR-655	tagcaaTGTATTAggaaag	0	AUAAUACA	m7b	Created	no TS	-0.085	-3.85

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78223659A>G			cosmic_v64_1651109				Colorectal
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3124-3p	tgtcttAGGAAAGgagatc	0	ACUUUCCU	m7b	Disrupted	-0.203	-0.059	No effect
hsa-miR-3667-3p	tgtcttagGGAAGGagatc	0	ACCUUCCU	m6b	Created	no TS	-0.148	-6.1
hsa-miR-384	tgtctTAGGAAaggagatc	0	AUUCCUAG	m6b	Disrupted	-0.066	no TS	0.54
hsa-miR-3124-3p	tgtcttAGGAAAGgagatc	32767	ACUUUCCU	m7b	Disrupted	-0.203000	-0.059000	No effect
hsa-miR-3667-3p	tgtcttagGGAAGGagatc	32767	ACCUUCCU	m6b	Created	no TS	-0.148000	-6.100000
hsa-miR-384	tgtctTAGGAAaggagatc	32767	AUUCCUAG	m6b	Disrupted	-0.066000	no TS	0.540000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78223712->T			ICGC_ssm_v3_22274		BN50T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3617	tgtttTGTCTTTgaaagtgg	0	AAAGACAU	m7a	Created	-0.205000	-0.205000	0.750000
hsa-miR-548u	tgttttGTCTTTGaaagtgg	0	CAAAGACU	m7a	Created	NA	NA	-1.480000
hsa-miR-641	tgtttTGTCTTTgaaagtgg	0	AAAGACAU	m7a	Created	-0.194000	-0.194000	1.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78223775TC>-			ICGC_1428649		TCGA-AP-A0LP-01A-12D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78224056G>T			ICGC_6865AF92-2A78-11E2-848B-FEFC496BB9B8		CPCG_0006_Pr_P_F0		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3529-3p	tgTTGTTGTTtttttttgt	0	AACAACAA	m8a	(m7a->m8a)	-0.221	-0.263	-1.75
hsa-miR-5003-5p	tgtTGTTGTGtttttttgt	0	UCACAACA	m7b	(m7b->m6b)	-0.248	-0.077	0.09

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78225488G>A			COSN4770657		tumor_4177376		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1538	gagcccctCGGGCCaactg	32767	CGGCCCGG	m6b	Disrupted	-0.242000	no TS	0.010000
hsa-miR-3184-5p	gaGCCCCTCAggccaactg	32767	UGAGGGGC	m8a	(m7a->m8a)	-0.354000	-0.584000	-1.910000
hsa-miR-328	gagcccctcGGGCCAactg	32767	CUGGCCCU	m6b	Disrupted	-0.185000	no TS	6.800000
hsa-miR-423-5p	gaGCCCCTCAggccaactg	32767	UGAGGGGC	m8a	(m7a->m8a)	-0.345000	-0.572000	-0.230000
hsa-miR-4745-3p	gagcccctCGGGCCAactg	32767	UGGCCCGG	m7a	Disrupted	-0.246000	no TS	No effect
hsa-miR-544b	gagccCCTCAGGccaactg	32767	ACCUGAGG	m7b	Created	no TS	-0.105000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.78225600C>A			COSN9323436		AOCS-057-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4424	agagTAACTCacaattgcc	32767	AGAGUUAA	m6b	Disrupted	-0.101000	no TS	4.330000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
78223650	rs140169554	C	T	hsa-miR-3617-5p hsa-miR-641	0	tagcaATGTCTTA tagcaATGTCTTA	Created Created	N N	-0.205 -0.194
			C	hsa-miR-208a-3p hsa-miR-208b-3p	0	tagcaaCGTCTTA tagcaaCGTCTTA	Disrupted Disrupted	N N	-0.172 -0.19
78223658	rs17882627	G	G	hsa-miR-3124-3p hsa-miR-3685 hsa-miR-384	0	tcttAGGAAAGga tctTAGGAAAgga tctTAGGAAAgga	Disrupted Disrupted Disrupted	N N N	-0.144 -0.061 -0.066
			A	hsa-miR-4263 hsa-miR-576-5p hsa-miR-627-3p	0	tCTTAGAAAagga tcTTAGAAAagga tcttAGAAAAGga	Created Created Created	N N N	-0.219 -0.006 -0.121
78224046	rs146639575	-	TTG	hsa-miR-3065-5p hsa-miR-3529-3p hsa-miR-3613-3p	0	cagttttTTTGTTGttg cagtttttTTGTTGTtg cagtTTTTTTGttgttg	Unknown Unknown Unknown	N N N	-0.002 -0.081 -0.005
			-
78224052	rs202011142	-	T	hsa-miR-3529-3p hsa-miR-5003-5p	0	TTGTTGTtgtgtt ttgtTGTTGTGtt	Unknown Unknown	N N	-0.095 0.002
			-
78224053	rs199602253	T	T	hsa-miR-3529-3p hsa-miR-5003-5p	0	tgTTGTTGTgttt tgtTGTTGTGttt	Disrupted Disrupted	N N	-0.117 -0.016
			G	hsa-miR-21-3p hsa-miR-3591-3p	0	tgttgTGGTGTTt tgttgTGGTGTTt	Created Created	N N	-0.17 -0.18
78224054	rs200361238	G	G	hsa-miR-3529-3p hsa-miR-5003-5p	0	gTTGTTGTgtttt gtTGTTGTGtttt	Disrupted Disrupted	N N	-0.063 -0.171
78224056	rs201472247	T	G	hsa-miR-5003-5p	0	TGTTGTGtttttt	Created	N	-0.171
78225222	rs17879923	G	G	hsa-miR-3180 hsa-miR-3180-3p hsa-miR-3184-5p hsa-miR-3196 hsa-miR-423-5p hsa-miR-6816-5p	0	ggagCCGCCCCtc ggagCCGCCCCtc ggagccGCCCCTC ggagCCGCCCCtc ggagccGCCCCTC ggagCCGCCCCtc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.218 -0.218 -0.114 -0.208 -0.133 -0.208
			A	hsa-miR-1914-3p hsa-miR-4651 hsa-miR-5194 hsa-miR-608 hsa-miR-6738-5p hsa-miR-6782-5p	0	ggagccACCCCTC ggagCCACCCCtc ggagccACCCCTC ggagCCACCCCtc ggagccACCCCTC ggagcCACCCCTc	Created Created Created Created Created Created	N N N N N N	-0.087 -0.123 -0.069 -0.123 -0.106 -0.101

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