SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001188
Gene Symbol:	BAK1
Description:	Homo sapiens BCL2-antagonist/killer 1 (BAK1), mRNA.
Gene Location:	chr6(-):33540322-33548070
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.33572911->G			cosmic_v64_1870281		NA		[upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-125a-5p	gttataTCAGGGAaaagga	0	UCCCUGAG	m7a	Disrupted	-0.548000	-0.394000	0.300000
hsa-miR-125b-5p	gttataTCAGGGAaaagga	0	UCCCUGAG	m7a	Disrupted	-0.606000	-0.445000	0.010000
hsa-miR-331-3p	gttatatCAGGGGaaaagga	0	GCCCCUGG	m6b	Created	-0.396000	-0.580000	-0.160000
hsa-miR-345-3p	gttataTCAGGGaaaagga	0	GCCCUGAA	m6b	Disrupted	-0.232000	-0.085000	0.870000
hsa-miR-3679-3p	gttatatcaGGGGAAaagga	0	CUUCCCCC	m6b	Created	-0.231000	-0.360000	-0.060000
hsa-miR-4319	gttataTCAGGGAaaagga	0	UCCCUGAG	m7a	Disrupted	-0.569000	-0.415000	1.090000
hsa-miR-4446-5p	gttatatcAGGGAAAagga	0	AUUUCCCU	m7b	Disrupted	-0.167000	-0.051000	-1.030000
hsa-miR-4732-3p	gttataTCAGGGaaaagga	0	GCCCUGAC	m6b	Disrupted	-0.379000	-0.228000	1.160000
hsa-miR-4755-5p	gttatatcAGGGAAAagga	0	UUUCCCUU	m7a	Disrupted	-0.085000	no TS	-0.970000
hsa-miR-5006-3p	gttatatcAGGGAAAagga	0	UUUCCCUU	m7a	Disrupted	-0.092000	no TS	-1.210000
hsa-miR-670	gttataTCAGGGAaaagga	0	GUCCCUGA	m7b	Disrupted	-0.447000	-0.071000	0.880000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.33573526C>T			COSN15118594		LP6005690-DNA_C02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3065-3p	tctgctaGGTGCTGgggag	0	UCAGCACC	m7b	Created	no TS	-0.154000	-0.190000
hsa-miR-4738-5p	tctgctagGCGCTGGggag	1	ACCAGCGC	m7b	Disrupted	-0.253000	no TS	2.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.33573570T>G			COSN7870975		8012341		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3150b-3p	gtggccgTCTCCTCcctca	1	UGAGGAGA	m7b	Disrupted	-0.390000	-0.357000	No effect
hsa-miR-4784	gtggccgTCTCCTCcctca	1	UGAGGAGA	m7b	Disrupted	-0.368000	-0.344000	No effect
hsa-miR-765	gtggccgtCTCCTCCctca	1	UGGAGGAG	m7b	Disrupted	-0.238000	-0.124000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.33573665G>T			COSN7870976		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1470	agcttCGGAGGGCccctgc	2	GCCCUCCG	m8a	Disrupted	-0.219000	no TS	No effect
hsa-miR-4290	agcttcGGAGGGCccctgc	3	UGCCCUCC	m7b	Disrupted	-0.170000	no TS	0.010000
hsa-miR-4529-5p	agcttcgGATGGCCcctgc	0	AGGCCAUC	m7b	Created	no TS	-0.129000	-0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
33572653	rs1051940	G	G	hsa-miR-4713-5p hsa-miR-629-3p hsa-miR-6867-3p	2 2 2	ggGGGAGAAgttc ggGGGAGAAgttc ggGGGAGAAgttc	Disrupted Disrupted Disrupted	N N N	-0.119 -0.101 -0.133
			A	hsa-miR-3679-3p hsa-miR-4446-5p hsa-miR-5003-3p	0	GGGGGAAAagttc ggGGGAAAAgttc ggggGAAAAGTtc	Created Created Created	N N N	-0.361 -0.054 0.013
33572915	rs145004927	T	A	hsa-miR-410-3p	0	tGTTATATcaggg	Created	N	-0.003
			T	hsa-miR-345-3p	1	tgttatTTCAGGG	Disrupted	N	-0.186

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