SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001186
Gene Symbol: BACH1
Description: Homo sapiens BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1), transcript variant 2, mRNA.
Gene Location: chr21(+):30671219-30718469
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr21:g.29343586C>T COSN8565244 tumor_4163639 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-3p catggacttTCTATTTcct
 15
 UAAAUAGA m7b (m6c->m7b) -0.095000 -0.044000 No effect
hsa-miR-4476 catggaCTTCCTatttcct
 1
 CAGGAAGG m6b Disrupted -0.023000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr21:g.29343971C>T COSN5984562 RK162_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1253 tgctcTCTTCTCcaaattt
 10
 AGAGAAGA m7b Disrupted -0.049000 -0.065000 2.950000
hsa-miR-1270 tgctctctTCTCCAaattt
 1
 CUGGAGAU m6b Disrupted -0.036000 no TS 0.360000
hsa-miR-3148 tgctctcTTTTCCAaattt
 0 UGGAAAAA m7a Created -0.019000 0.066000 No effect
hsa-miR-3978 tgctctctTTTCCAaattt
 0 GUGGAAAG m6b Created no TS 0.049000 -0.040000
hsa-miR-4311 tgcTCTCTTTtccaaattt
 0 GAAAGAGA m7b (m6b->m7b) no TS 0.082000 -0.440000
hsa-miR-4434 tgctctCTTCTCCaaattt
 7
 AGGAGAAG m7b Disrupted -0.191000 -0.093000 0.030000
hsa-miR-4516 tgctctCTTCTCCaaattt
 7
 GGGAGAAG m7b Disrupted -0.156000 -0.058000 1.500000
hsa-miR-4531 tgctctcTTCTCCAaattt
 7
 AUGGAGAA m7b Disrupted -0.135000 -0.110000 0.010000
hsa-miR-5197-3p tgctCTCTTCTccaaattt
 1
 AAGAAGAG m7b Disrupted 0.011000 no TS 0.100000
hsa-miR-5703 tgctctCTTCTCCaaattt
 7
 AGGAGAAG m7b Disrupted -0.211000 -0.081000 0.120000
hsa-miR-620 tgctctctTCTCCAaattt
 1
 AUGGAGAU m6b Disrupted -0.029000 no TS 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.29344660G>A COSN7143246 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3941 tgtGTGTGTAtgtgtgtgt
 0 UUACACAC m7b (m6b->m7b) 0.042000 0.075000 0.130000
hsa-miR-4789-3p tgtgtgtgTATGTGTGtgt
 1
 CACACAUA m8a Created 0.149000 0.254000 0.400000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.29344666G>A COSN7143247 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-329 tgtgtgtGTGTGTatgtgt
 0 AACACACC m6b Disrupted 0.037000 0.034000 0.150000
hsa-miR-362-3p tgtgtgtGTGTGTatgtgt
 0 AACACACC m6b Disrupted 0.037000 0.034000 0.100000
hsa-miR-3941 tgtgtgtGTGTGTAtgtgt
 0 UUACACAC m7b Disrupted 0.042000 0.035000 0.200000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.29345005C>A COSN10025188 C0059T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-452-5p acctatAAACAGTTtagca
 0 AACUGUUU m8a Disrupted -0.056000 no TS 2.450000
hsa-miR-4676-3p acctatAAACAGTttagca
 0 CACUGUUU m7b Disrupted -0.010000 no TS 0.110000
hsa-miR-548av-3p acctataaaCAGTTTagca
 10
 AAAACUGC m6b Disrupted 0.043000 no TS 0.020000
hsa-miR-548g-3p acctataaACAGTTTagca
 3
 AAAACUGU m7b Disrupted -0.100000 -0.097000 0.600000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.29345931A>G COSN8611632 J46_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3617 tttttttATGTCTTTcata
 2
 AAAGACAU m8a Created 0.136000 -0.083000 -0.370000
hsa-miR-641 tttttttATGTCTTTcata
 2
 AAAGACAU m8a Created 0.117000 -0.083000 -1.400000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
29342938 rs1056826 C C hsa-miR-3148
hsa-miR-4509
hsa-miR-651-3p
9
9
10
 TTTTTCCtttagt
tttttCCTTTAGt
ttTTTCCTTtagt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.141
-0.235
-0.152
29343164 rs2070401 A A hsa-miR-302f
2
 acAGCAATTtaac
 Disrupted
N
 -0.103
G hsa-miR-548av-3p
hsa-miR-548g-3p
2
2
 acaGCAGTTTAac
acagCAGTTTAac
 Created
Created
N
N
 -0.242
-0.029
29343272 rs141400608 C C hsa-miR-450a-1-3p
hsa-miR-4747-5p
hsa-miR-5196-5p
2
2
2
 tttcTTCCCAAgc
tttCTTCCCAagc
tttCTTCCCAagc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.141
-0.123
-0.116
T hsa-miR-3978
2
 tttCTTTCCAAgc
 Created
N
 -0.24
29344675 rs143788431 T T hsa-miR-4643
hsa-miR-466
hsa-miR-4789-3p
2
2
1
 tATGTGTAtgtat
tATGTGTAtgtat
TATGTGTAtgtat
 Disrupted
Disrupted
Disrupted
N
N
N
 0.084
0.012
0.149
C hsa-miR-5589-3p
2
 tATGTGCAtgtat
 Created
N
 0.027

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