SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_020371
Gene Symbol:	AVEN
Description:	Homo sapiens apoptosis, caspase activation inhibitor (AVEN), mRNA.
Gene Location:	chr15(-):34158427-34331303
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33866277A>G			COSN8742300		AOCS-063-1-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-26a-1-3p	agAGAATAGGtgcaaacaa	3	CCUAUUCU	m8a	(m7b->m8a)	-0.258000	-0.116000	0.030000
hsa-miR-26a-2-3p	agAGAATAGGtgcaaacaa	3	CCUAUUCU	m8a	(m7b->m8a)	-0.258000	-0.116000	0.070000
hsa-miR-3680-3p	agagaatagATGCAAAcaa	5	UUUUGCAU	m7b	(m7b->m6b)	-0.097000	no TS	0.390000
hsa-miR-500a-3p	agagaatAGGTGCAaacaa	0	AUGCACCU	m7b	Created	no TS	-0.476000	-4.400000
hsa-miR-507	agagaatagGTGCAAAcaa	0	UUUUGCAC	m7b	(m6b->m7b)	no TS	-0.132000	-5.010000
hsa-miR-557	agagaatagGTGCAAACaa	0	GUUUGCAC	m8a	(m7a->m8a)	no TS	-0.132000	-1.390000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33866537A>C			COSN8865238		SNUH_G22_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2861	tccttCAGGCCCagccagt	0	GGGGCCUG	m7b	Created	no TS	-0.465000	-5.860000
hsa-miR-4505	tccttcaggCCCAGCCagt	1	AGGCUGGG	m7b	(m6b->m7b)	-0.154000	-0.422000	-10.320000
hsa-miR-5589-5p	tccttcaggCCCAGCCagt	0	GGCUGGGU	m7a	(m6a->m7a)	NA	NA	-4.750000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33866560T>G			COSN1175894		HX16T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1224-3p	aacggcAGGTGGGcataag	3	CCCCACCU	m7b	Disrupted	-0.156000	no TS	1.070000
hsa-miR-1224-3p	aacggcAGGTGGGcataag	3	CCCCACCU	m7b	Disrupted	-0.156000	no TS	1.070000
hsa-miR-1224-3p	aacggcAGGTGGGcataag	0	CCCCACCU	m7b	Disrupted	-0.156	no TS	1.07

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
33866535	rs74008366	C	C	hsa-miR-3064-5p hsa-miR-3652 hsa-miR-4430 hsa-miR-4505 hsa-miR-5787 hsa-miR-6131 hsa-miR-6504-5p hsa-miR-6842-3p hsa-miR-7152-3p	2 1 1 1 1 1 2 1 1	caggacCAGCCAG caggaCCAGCCAg caggaCCAGCCAg caggaCCAGCCAg caggaCCAGCCAg cagGACCAGCcag caggacCAGCCAG caggaCCAGCCAg caGGACCAGccag	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.202 -0.159 -0.155 -0.154 -0.15 -0.217 -0.202 -0.248 -0.27
			G	hsa-miR-149-5p	2	caggacGAGCCAG	Created	N	-0.215
33866560	rs199781400	T	T	hsa-miR-1224-3p	3	ggcAGGTGGGcat	Disrupted	N	-0.156
			G	hsa-miR-4313 hsa-miR-6752-3p hsa-miR-6801-3p hsa-miR-6810-3p	2 2 3 3	ggcagGGGGGCAt GGCAGGGgggcat gGCAGGGGggcat gGCAGGGGggcat	Created Created Created Created	N N N N	-0.256 -0.206 -0.197 -0.206

Genome Browser