SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_015570
Gene Symbol: AUTS2
Description: Homo sapiens autism susceptibility candidate 2 (AUTS2), transcript variant 2, mRNA.
Gene Location: chr7(+):69063905-70257885
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791162A>G COSN2233424 RK014_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p atgttTTGTATAttatatg
17
CUAUACAA m7b Disrupted -0.144000 no TS -0.280000
hsa-let-7b-3p atgttTTGTATAttatatg
17
CUAUACAA m7b Disrupted -0.144000 no TS -0.020000
hsa-let-7f-1-3p atgttTTGTATAttatatg
17
CUAUACAA m7b Disrupted -0.163000 no TS -1.110000
hsa-miR-1277-5p atgttttgTATATTatatg
13
AAAUAUAU m6b Disrupted 0.199000 0.193000 1.450000
hsa-miR-369-3p atgttttgtGTATTATatg
11
AAUAAUAC m7b (m6c->m7b) 0.005000 -0.168000 -0.770000
hsa-miR-374c-5p atgttttgTGTATTATatg
0 AUAAUACA m8a Created no TS -0.081000 -0.660000
hsa-miR-4666a-3p atgttTTGTATattatatg
17
CAUACAAU m6b Disrupted -0.057000 no TS 0.380000
hsa-miR-4731-3p atgttTTGTGTattatatg
13
CACACAAG m6b Created -0.376000 -0.478000 No effect
hsa-miR-5692b atgttttgtATATTATatg
11
AAUAAUAU m7b (m7b->m6c) -0.099000 0.009000 No effect
hsa-miR-5692c atgttttgtATATTATatg
11
AAUAAUAU m7b (m7b->m6c) -0.099000 0.009000 -0.050000
hsa-miR-655 atgttttgTGTATTATatg
0 AUAAUACA m8a Created no TS -0.127000 -1.430000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791202A>G COSN15032743 LP6005409-DNA_H01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5580-3p agcccagtCATATGTtctc
5
CACAUAUG m7b Disrupted -0.110000 -0.024000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791218C>G COSN8517544 3498_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4771 ctcacGTCTGCTacttttt
0 AGCAGACU m7a Created NA NA -1.110000
hsa-miR-562 ctcacgtctGCTACTTTtt
0 AAAGUAGC m8a (m7b->m8a) no TS -0.194000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791378T>A COSN1353060 HCC82T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-602 aaggCCGTGTacatagtta
0 GACACGGG m6b Disrupted -0.181000 no TS 6.940000
hsa-miR-602 aaggCCGTGTacatagtta
0 GACACGGG m6b Disrupted -0.181 no TS 6.94

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791569T>C COSN6890321 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1277-5p gttcccATATATTgttata
13
AAAUAUAU m7b Disrupted 0.199000 0.069000 No effect
hsa-miR-3115 gttCCCATATattgttata
0 AUAUGGGU m7a (m7a->m6a) NA NA 0.850000
hsa-miR-338-5p gttcccatATATTGTTata
18
AACAAUAU m8a Disrupted -0.067000 -0.030000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70791819C>G COSN8037228 8057484 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-361-3p ttgtgggctCTGGGGGAaa
0 UCCCCCAG m8a (m8a->m7b) -0.470000 -0.333000 No effect
hsa-miR-4690-3p ttgTGGGCTGtgggggaaa
0 GCAGCCCA m7b (m6b->m7b) no TS -0.083000 -0.020000
hsa-miR-5685 ttgTGGGCTGTgggggaaa
0 ACAGCCCA m8a Created no TS -0.046000 -0.050000


Mutation Mutation ID Sample Name Cancer Type
chr7:g.70792149T>G COSN8037229 8052570 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.70792518G>A COSN8517545 J73_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20b-3p ttaACTACAGaccattgtt
0 ACUGUAGU m7b (m7b->m6b) -0.321000 no TS 5.862500
hsa-miR-3674 ttaaCTACAAaccattgtt
0 AUUGUAGA m6b Created no TS -0.079000 -1.600000
hsa-miR-5087 ttaactACAAACCattgtt
0 GGGUUUGU m7b Created no TS -0.330000 -1.080000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.70792612G>A COSN4871345 tumor_4177376 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-3p atgttgtgCAGTGTTtttt
0 UAACACUG m7b Created no TS -0.154000 -0.010000
hsa-miR-200a-3p atgttgtgCAGTGTTtttt
0 UAACACUG m7b Created no TS -0.163000 -0.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
70791090 rs188289236 - T hsa-miR-361-3p
hsa-miR-622
3
5
acagaCTGGGGGg
aCAGACTGggggg
Unknown
Unknown
N
N
-0.25
-0.12
70791092 rs191344881 G G hsa-miR-361-3p
3
agaCTGGGGGgga
Disrupted
N
-0.066

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