SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003600
Gene Symbol:	AURKA
Description:	Homo sapiens aurora kinase A (AURKA), transcript variant 2, mRNA.
Gene Location:	chr20(-):54944444-54967351
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.56369863C>T			COSN195679		PD4198a		[NS][NS][NS][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-21-3p	gcaTGGTGTTttcacagga	0	CAACACCA	m7b	(m6c->m7b)	no TS	-0.109000	-11.350000
hsa-miR-3591-3p	gcaTGGTGTTTtcacagga	0	AAACACCA	m8a	Created	no TS	-0.146000	-2.650000
hsa-miR-3611	gcatggtgtCTTCACAgga	1	UUGUGAAG	m7b	(m7b->m6b)	-0.061000	no TS	0.850000
hsa-miR-570-3p	gcatggTGTTTTCacagga	0	CGAAAACA	m7b	Created	no TS	0.006000	-1.400000
hsa-miR-21-3p	gcaTGGTGTTttcacagga	0	CAACACCA	m7b	(m6c->m7b)	no TS	-0.109	-11.35
hsa-miR-3591-3p	gcaTGGTGTTTtcacagga	0	AAACACCA	m8a	Created	no TS	-0.146	-2.65
hsa-miR-3611	gcatggtgtCTTCACAgga	0	UUGUGAAG	m7b	(m7b->m6b)	-0.061	no TS	0.85
hsa-miR-570-3p	gcatggTGTTTTCacagga	0	CGAAAACA	m7b	Created	no TS	0.006	-1.4

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
56369861	rs182111018	T	T	hsa-miR-3611	1	gtgtCTTCACAgg	Disrupted	N	-0.061
			G	hsa-miR-1273h-3p hsa-miR-143-5p hsa-miR-1914-5p hsa-miR-3166 hsa-miR-3944-5p hsa-miR-4771	1 1 1 1 1 1	gtGTCTGCAcagg gtgtCTGCACAgg gtgtctGCACAGG gTGTCTGCAcagg gtgtCTGCACAgg gtGTCTGCAcagg	Created Created Created Created Created Created	N N N N N N	-0.142 -0.076 -0.252 -0.294 -0.084 -0.109

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