SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001678
Gene Symbol: ATP1B2
Description: Homo sapiens ATPase, Na+/K+ transporting, beta 2 polypeptide (ATP1B2), mRNA.
Gene Location: chr17(+):7554253-7561089
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.7656106C>G COSN9323264 AOCS-078-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1266 tcccaaCCTGAGatcagtc
 2
 CCUCAGGG m6b Created -0.387000 -0.504000 0.490000
hsa-miR-1285-5p tcccaaccTGAGATCagtc
 0 GAUCUCAC m7a Created NA NA -0.030000
hsa-miR-3200-5p tcccaacCTCAGATcagtc
 1
 AAUCUGAG m7b Disrupted -0.072000 no TS 4.320000
hsa-miR-377-5p tccCAACCTCagatcagtc
 0 AGAGGUUG m7b (m7b->m6b) -0.288000 no TS 0.360000
hsa-miR-4518 tcccaaCCTGAGatcagtc
 2
 GCUCAGGG m6b Created -0.399000 -0.502000 No effect
hsa-miR-4695-3p tcccaaccTGAGATCAgtc
 0 UGAUCUCA m8a Created no TS -0.217000 1.130000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7656349C>T COSN9323266 AOCS-145-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4694-3p cctTCCATTTctaagctct
 0 CAAAUGGA m7b (m6b->m7b) no TS -0.027000 -1.910000
hsa-miR-5680 ccttcCATTTCTaagctct
 0 GAGAAAUG m7b Created no TS 0.000000 -0.080000
hsa-miR-613 ccttcCATTCCTaagctct
 0 AGGAAUGU m7a Disrupted NA NA 0.290000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7656947T>C ICGC_AF466D20-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4530 cccaaagTGCTGGGattac
 0 CCCAGCAG m7a Created NA NA No effect
hsa-miR-4733-5p cccaaagtgTTGGGATTac
 0 AAUCCCAA m8a (m8a->m7b) -0.001 no TS 2.42

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7656976C>T COSN6661010 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3178 cacCGCGCCCggccttcag
 0 GGGGCGCG m7b (m7b->m6b) -0.169000 no TS 0.010000
hsa-miR-4753-5p caccgcgccTGGCCTTcag
 11
 CAAGGCCA m7b (m6c->m7b) -0.115000 -0.110000 No effect
hsa-miR-4755-3p caccgcGCCTGGCcttcag
 0 AGCCAGGC m7b Created no TS -0.079000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7657411C>A COSN14629487 8065126 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-218-2-3p acaaaaaaAACCATaatgc
 0 CAUGGUUC m6b Created no TS -0.093000 -5.640000
hsa-miR-3115 acaaaaaaACCCATAatgc
 2
 AUAUGGGU m7b Disrupted -0.400000 no TS 1.460000
hsa-miR-584-5p acaaaaaaAACCATAAtgc
 0 UUAUGGUU m8a Created no TS -0.284000 -3.990000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7657457C>T COSN8246466 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2278 tgcctcCTGCTCTgaatat
 2
 GAGAGCAG m7b Disrupted -0.119000 no TS 3.270000
hsa-miR-4722-5p tgcCTCCTGCtctgaatat
 2
 GGCAGGAG m7b (m7b->m6b) -0.506000 -0.373000 No effect
hsa-miR-4773 tgcctcCTGTTCTGaatat
 0 CAGAACAG m8a Created no TS -0.070000 -0.150000
hsa-miR-589-3p tgcctccTGTTCTGAatat
 0 UCAGAACA m8a Created no TS -0.179000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7657517T>G COSN6661011 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-5p tcccttcacGTCCTCAtcc
 0 GUGAGGAC m7b (m6c->m7b) no TS -0.172000 -2.930000
hsa-miR-3915 tcccttcacTTCCTCAtcc
 0 UUGAGGAA m7b (m7b->m6c) -0.103000 no TS 0.010000
hsa-miR-3928 tcccttcacTTCCTCatcc
 0 GGAGGAAC m6b Disrupted -0.097000 no TS 0.070000
hsa-miR-4751 tcccttcacGTCCTCatcc
 0 AGAGGACC m6b Created no TS -0.164000 -0.370000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
7656040 rs35855036 - T hsa-miR-1253
hsa-miR-580-3p
hsa-miR-6770-5p
1
1
1
 ttgaCTTCTCAac
ttgacTTCTCAAc
ttgaCTTCTCAac
 Unknown
Unknown
Unknown
N
N
N
 -0.054
-0.042
-0.052
C hsa-miR-1224-5p
hsa-miR-3150b-3p
hsa-miR-3915
hsa-miR-4689
hsa-miR-4784
hsa-miR-6858-5p
1
1
1
1
1
1
 ttgacTCCTCAAc
ttgaCTCCTCAac
ttgacTCCTCAAc
ttgaCTCCTCAAc
ttgaCTCCTCAac
ttgaCTCCTCAAc
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
 -0.112
-0.115
-0.094
-0.325
-0.119
-0.325
7656172 rs181025749 - G hsa-miR-497-3p
1
 gttcTGGTTTAgc
 Unknown
N
 -0.023
A hsa-miR-2115-3p
hsa-miR-551b-5p
hsa-miR-589-3p
1
1
1
 gTTCTGATttagc
gttcTGATTTAgc
GTTCTGAtttagc
 Unknown
Unknown
Unknown
N
N
N
 -0.096
0.045
-0.076
7656544 rs116741402 C
T hsa-miR-589-3p
1
 ctggcaTGTTCTG
 Created
N
 -0.049
7656976 rs1050533 T C hsa-miR-3178
hsa-miR-6499-5p
0 CGCGCCCggcctt
cGCGCCCGgcctt
 Created
Created
N
N
 -0.169
-0.205
T hsa-miR-4753-5p
hsa-miR-4755-3p
1
0
 cgcgccTGGCCTT
cgcGCCTGGCctt
 Disrupted
Disrupted
N
N
 0.005
-0.079
7657517 rs1050541 T T hsa-miR-3915
hsa-miR-3928-3p
3
3
 cttcacTTCCTCA
cttcacTTCCTCA
 Disrupted
Disrupted
N
N
 -0.103
-0.097
G hsa-miR-1224-5p
hsa-miR-4751
hsa-miR-5004-5p
3
3
3
 cttcacGTCCTCA
cttcacGTCCTCA
cttcacGTCCTCA
 Created
Created
Created
N
N
N
 -0.172
-0.164
-0.141

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