SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000051
Gene Symbol:	ATM
Description:	Homo sapiens ataxia telangiectasia mutated (ATM), mRNA.
Gene Location:	chr11(+):108093558-108239826
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108365786A>G			ICGC_A96EA9D0-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1224-3p	gccgAGGTGGGcggatcac	0	CCCCACCU	m7b	Created	no TS	-0.109	-4.69
hsa-miR-572	gccgaggtGAGCGGAtcac	0	GUCCGCUC	m7b	Disrupted	-0.292	no TS	0.36

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108366669A>G			COSN5893961		RK081_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3688-3p	agggTTTCCATAcctgaag	1	UAUGGAAA	m8a	Disrupted	0.090000	no TS	0.420000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108366932A>G			COSN5893962		RK150_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3972	agaCTGGCAGattgttcca	3	CUGCCAGC	m7a	(m6a->m7a)	-0.025000	no TS	0.450000
hsa-miR-4727-5p	agacTGGCAGATtgttcca	2	AUCUGCCA	m8a	Created	-0.070000	-0.078000	-1.230000
hsa-miR-4776-3p	agacTGGCAAattgttcca	2	CUUGCCAU	m6b	Disrupted	0.008000	no TS	0.080000
hsa-miR-5006-5p	agaCTGGCAAattgttcca	3	UUGCCAGG	m7a	(m7a->m6a)	-0.010000	no TS	0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108367773A>C			COSN4696212		PD4109a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4470	cttgGTTTGCCttctggag	2	UGGCAAAC	m7b	Created	-0.183000	-0.222000	-5.310000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108367964T>C			COSN10077511		C0047T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-205-3p	gggTGAAATCagaaattat	6	GAUUUCAG	m7a	(m6a->m7a)	0.106000	0.110000	-0.030000
hsa-miR-29a-5p	gggtgAAATCAGaaattat	1	ACUGAUUU	m7b	Created	-0.082000	-0.034000	-0.040000
hsa-miR-3920	gggtgaAATCAGaaattat	3	ACUGAUUA	m6b	Created	-0.101000	-0.070000	-0.300000
hsa-miR-4263	gggtgaaaTTAGAAattat	3	AUUCUAAG	m6b	Disrupted	0.042000	-0.029000	-0.010000
hsa-miR-4735-5p	gggtgAAATTAGaaattat	0	CCUAAUUU	m7b	Disrupted	0.143000	0.025000	0.020000
hsa-miR-4762-3p	gggtgaaATCAGAAattat	1	CUUCUGAU	m7b	Created	-0.084000	-0.095000	-0.140000
hsa-miR-576-5p	gggtgaaATTAGAAattat	3	AUUCUAAU	m7b	Disrupted	0.026000	-0.013000	0.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108368403A>T			COSN15538075		AOCS-064-1-6		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-26a-1-3p	taatcatAGAATAGttgtt	0	CCUAUUCU	m7b	Disrupted	-0.328000	-0.190000	1.670000
hsa-miR-26a-2-3p	taatcatAGAATAGttgtt	0	CCUAUUCU	m7b	Disrupted	-0.356000	-0.190000	7.770000
hsa-miR-26a-1-3p	taatcatAGAATAGttgtt	0	CCUAUUCU	m7b	Disrupted	-0.328000	-0.190000	1.670000
hsa-miR-26a-2-3p	taatcatAGAATAGttgtt	0	CCUAUUCU	m7b	Disrupted	-0.356000	-0.190000	7.770000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
108365713	rs147355837	T	T	hsa-miR-1276 hsa-miR-4263 hsa-miR-4311 hsa-miR-4509 hsa-miR-4744 hsa-miR-4799-5p hsa-miR-576-5p hsa-miR-583	2 4 2 2 1 4 4 2	aCTCTTTAgaaat actctTTAGAAAt aCTCTTTAgaaat actCTTTAGAaat acTCTTTAGAaat actcTTTAGAAat actctTTAGAAAt aCTCTTTAgaaat	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.043 0.006 -0.019 -0.049 -0.174 -0.009 0.014 -0.024
			C	hsa-miR-4709-3p hsa-miR-4762-3p	2 4	aCTCTTCAgaaat actctTCAGAAAt	Created Created	N N	-0.156 -0.042
108365879	rs3092835	A	A	hsa-miR-4735-5p hsa-miR-4775 hsa-miR-590-3p	2 2 2	acaaAAATTAGcc acaAAAATTAgcc acaAAAATTAgcc	Disrupted Disrupted Disrupted	N N N	0.025 0.092 0.14
108366329	rs12284801	G	G	hsa-miR-4762-3p hsa-miR-4766-5p	2 2	cttTCAGAAAttg CTTTCAGAaattg	Disrupted Disrupted	N N	-0.016 -0.106
			A	hsa-miR-488-3p hsa-miR-510-3p	2 2	CTTTCAAaaattg cTTTCAAAaattg	Created Created	N N	-0.002 0.04
108368913	rs11558526	G	G	hsa-miR-26a-1-3p hsa-miR-26a-2-3p hsa-miR-554	2 2 2	agactAGAATAGt agactAGAATAGt aGACTAGAatagt	Disrupted Disrupted Disrupted	N N N	-0.19 -0.19 -0.174
			A	hsa-miR-4474-5p	2	AGACTAAaatagt	Created	N	-0.133

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