SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_178427
Gene Symbol:	ARNT
Description:	Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 4, mRNA.
Gene Location:	chr1(-):150782180-150849244
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150809830G>A			COSN15010038		LP6005409-DNA_A02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-574-3p	tttggggTGAGCGTtgcct	0	CACGCUCA	m7b	Created	no TS	-0.201000	-2.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150810016G>A			COSN8642082		AOCS-086-3-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-145-3p	acaaccagAGGAATCtata	0	GGAUUCCU	m7b	Disrupted	-0.469000	-0.339000	1.900000
hsa-miR-3182	acaacCAGAAGaatctata	0	GCUUCUGU	m6b	Created	no TS	-0.080000	-2.350000
hsa-miR-326	acaaCCAGAGGaatctata	0	CCUCUGGG	m7a	Disrupted	NA	NA	2.360000
hsa-miR-4659a-3p	acaaccAGAAGAAtctata	4	UUUCUUCU	m7b	Created	-0.286000	-0.327000	-0.030000
hsa-miR-4659b-3p	acaaccAGAAGAAtctata	4	UUUCUUCU	m7b	Created	-0.286000	-0.327000	-0.590000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150810430T>A			COSN7177113		8030340		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-376a-3p	tatTCTATGAgcacactta	0	AUCAUAGA	m7b	(m6c->m7b)	no TS	-0.153000	-8.510000
hsa-miR-376b	tatTCTATGAgcacactta	0	AUCAUAGA	m7b	(m6c->m7b)	no TS	-0.153000	-5.440000
hsa-miR-376c	tatTCTATGTgcacactta	15	AACAUAGA	m7b	(m7b->m6c)	-0.120000	no TS	2.680000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150811479A>G			COSN6507075		CHC322T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3941	tgtGTGTGTAtgtgtgtgt	0	UUACACAC	m7b	(m7b->m6c)	-0.075000	no TS	No effect
hsa-miR-4789-3p	tgtgtgtgTATGTGTGtgt	0	CACACAUA	m8a	Disrupted	0.025000	no TS	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150811649G>A			COSN8642083		AOCS-166-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3124-3p	ttttGGAAAGaaattctga	8	ACUUUCCU	m6b	Disrupted	-0.083000	-0.010000	-0.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150811660G>T			9_127929		CRC-1-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
150811473	rs74127015	G
			A	hsa-miR-4643 hsa-miR-466 hsa-miR-4789-3p	0	ATGTGTAtgtgtg ATGTGTAtgtgtg atgtgTATGTGTg	Created Created Created	N N N	0.006 -0.061 -0.059
150811474	rs72334936	-	-	hsa-miR-4789-3p	0	gtgtgTATGTGTgtgtgtgtgtg	Unknown	N	0.025
			ATGTGT	hsa-miR-499a-3p hsa-miR-499b-3p	3 3	gtgtgtatGTGATGTgttgtgtgtgtgtg gtgtgtatGTGATGTgttgtgtgtgtgtg	Unknown Unknown	N N	-0.101 -0.101
150811478	rs138388886	-	-	hsa-miR-4789-3p	0	gtgtgtgTATGTGTgtgtg	Unknown	N	-0.001
			TGTG
150811479	rs61817635	G	A	hsa-miR-329-3p hsa-miR-362-3p hsa-miR-3941 hsa-miR-4789-3p hsa-miR-603	0	GTGTGTAtgtgtg GTGTGTAtgtgtg GTGTGTAtgtgtg gtgtgTATGTGTg GTGTGTAtgtgtg	Created Created Created Created Created	N N N N N	-0.05 -0.047 -0.075 0.025 -0.054
150811654	rs200023378	G	G	hsa-miR-3124-3p	4	gtttttGGAAAGA	Disrupted	N	-0.073
			T	hsa-miR-3613-3p hsa-miR-607	4 4	gTTTTTTGAaaga gtttTTTGAAAga	Created Created	N N	0.012 0.046

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