SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_018125
Gene Symbol:	ARHGEF10L
Description:	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10-like (ARHGEF10L), transcript variant 2, mRNA.
Gene Location:	chr1(+):17866329-18024370
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.17697430A>G			COSN9367522		C0056T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1204	accaaGGCCACGcccggct	0	UCGUGGCC	m7b	Disrupted	-0.278000	no TS	1.790000
hsa-miR-1268a	accaaggcCACGCCCGgct	0	CGGGCGUG	m8a	Disrupted	-0.463000	-0.245000	0.720000
hsa-miR-1268b	accaaggcCACGCCCGgct	0	CGGGCGUG	m8a	Disrupted	-0.463000	-0.245000	0.720000
hsa-miR-3178	accaaggcCGCGCCCggct	0	GGGGCGCG	m7b	Created	no TS	-0.242000	-5.080000
hsa-miR-4479	accaagGCCGCGCccggct	0	CGCGCGGC	m7b	Created	no TS	-0.305000	-3.840000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.17697816T>C			COSN8636947		J76_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-2-3p	taaagtCTGTACAtattgg	12	CUGUACAG	m7b	Disrupted	-0.233000	no TS	0.110000
hsa-let-7g-3p	taaagtCTGTACAtattgg	12	CUGUACAG	m7b	Disrupted	-0.233000	no TS	2.860000
hsa-miR-143-5p	taaagtCTGCACatattgg	0	GGUGCAGU	m6b	Created	no TS	-0.176000	-0.130000
hsa-miR-3166	taaaGTCTGCacatattgg	0	CGCAGACA	m6b	Created	no TS	-0.204000	-0.010000
hsa-miR-4771	taaAGTCTGCacatattgg	0	AGCAGACU	m7b	(m6b->m7b)	no TS	-0.526000	0.350000
hsa-miR-499b-5p	taAAGTCTGTacatattgg	10	ACAGACUU	m8a	(m8a->m7a)	-0.259000	-0.231000	1.310000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
17697702	rs3766314	C	C	hsa-miR-1268a hsa-miR-1268b hsa-miR-644a	3 3 3	gccaCACGCCCct gccaCACGCCCct GCCACACgcccct	Disrupted Disrupted Disrupted	N N N	-0.245 -0.245 -0.149
			T	hsa-miR-4253 hsa-miR-4688 hsa-miR-6743-5p hsa-miR-6862-5p	3 9 12 4	gccaCATGCCCct gccacaTGCCCCT gccacaTGCCCCT gccaCATGCCCct	Created Created Created Created	N N N N	-0.157 -0.186 -0.186 -0.157

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