SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_015230
Gene Symbol: ARAP2
Description: Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (ARAP2), mRNA.
Gene Location: chr4(-):36067619-36245979
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr4:g.36066437G>A COSN9038886 AOCS-088-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374a-3p ttttggggTGATAAaatag
 8
 CUUAUCAG m6b Disrupted -0.008000 no TS No effect
hsa-miR-556-3p ttttggGGTAATAaaatag
 0 AUAUUACC m7b Created no TS -0.174000 -1.342000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.36066456A>G COSN5570164 RK164_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-100-5p aaaaTACGGGTcatttgta
 0 AACCCGUA m7b Created no TS -0.361000 -2.880000
hsa-miR-4454 aaaataCGGATCatttgta
 0 GGAUCCGA m6b Disrupted -0.228000 no TS 6.030000
hsa-miR-99a-5p aaaaTACGGGTcatttgta
 0 AACCCGUA m7b Created no TS -0.361000 -3.270000
hsa-miR-99b-5p aaaaTACGGGTcatttgta
 0 CACCCGUA m7b Created no TS -0.361000 -7.070000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.36066808G>T COSN2026881 RK159_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-28-3p ttaATCTAGTttttttttt
 0 CACUAGAU m7b (m6c->m7b) no TS -0.163000 -3.630000
hsa-miR-548ac ttaatctaGGTTTTTtttt
 2
 CAAAAACC m7b Disrupted 0.095000 0.175000 0.420000
hsa-miR-548ae ttaatctAGTTTTTttttt
 1
 CAAAAACU m7b Created -0.013000 -0.039000 -0.130000
hsa-miR-548ah-3p ttaatctAGTTTTTttttt
 1
 CAAAAACU m7b Created -0.044000 -0.061000 -0.010000
hsa-miR-548aj-3p ttaatctAGTTTTTttttt
 1
 UAAAAACU m7b Created -0.044000 -0.070000 -0.080000
hsa-miR-548am-3p ttaatctAGTTTTTttttt
 1
 CAAAAACU m7b Created -0.044000 -0.061000 No effect
hsa-miR-548aq-3p ttaatctAGTTTTTttttt
 1
 CAAAAACU m7b Created -0.033000 -0.059000 -0.040000
hsa-miR-548d-3p ttaatctaGGTTTTTtttt
 2
 CAAAAACC m7b Disrupted 0.143000 0.185000 0.390000
hsa-miR-548h-3p ttaatctaGGTTTTTtttt
 2
 CAAAAACC m7b Disrupted 0.108000 0.178000 0.730000
hsa-miR-548x-3p ttaatctAGTTTTTttttt
 1
 UAAAAACU m7b Created -0.013000 -0.039000 -0.120000
hsa-miR-548z ttaatctaGGTTTTTtttt
 2
 CAAAAACC m7b Disrupted 0.108000 0.178000 0.730000
hsa-miR-708-3p ttaaTCTAGTTtttttttt
 5
 CAACUAGA m7b Created -0.125000 -0.284000 -4.250000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
36066459 rs182271449 C C hsa-miR-4454
0 aaaataCGGATCA
 Disrupted
N
 -0.228
T hsa-miR-640
0 aaaataTGGATCA
 Created
N
 -0.235

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