SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001650
Gene Symbol: AQP4
Description: Homo sapiens aquaporin 4 (AQP4), transcript variant a, mRNA.
Gene Location: chr18(-):24432007-24445716
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr18:g.26853371T>C COSN9328880 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.26853474C>A COSN6117170 RK193_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-135b-3p aaggtggtCCCTACActga
 0 AUGUAGGG m7b Disrupted -0.138000 -0.099000 0.130000
hsa-miR-3649 aaggtGGTCCCTacactga
 0 AGGGACCU m7a Disrupted NA NA 0.680000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.26853627T>A COSN9677245 C0052T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15a-5p gcatagTGCTGCTcccagg
 3
 UAGCAGCA m7b Disrupted 0.032000 -0.001000 2.780000
hsa-miR-15b-5p gcatagTGCTGCTcccagg
 3
 UAGCAGCA m7b Disrupted 0.032000 -0.001000 3.870000
hsa-miR-16-5p gcatagTGCTGCTcccagg
 3
 UAGCAGCA m7b Disrupted 0.042000 -0.019000 2.360000
hsa-miR-195-5p gcatagTGCTGCTcccagg
 3
 UAGCAGCA m7b Disrupted 0.042000 -0.019000 No effect
hsa-miR-424-5p gcatagTGCTGCTcccagg
 3
 CAGCAGCA m7b Disrupted 0.032000 -0.001000 2.710000
hsa-miR-4300 gcatagtgcAGCTCCCAgg
 10
 UGGGAGCU m8a (m7a->m8a) -0.028000 -0.056000 -4.520000
hsa-miR-4793-3p gcatAGTGCAGctcccagg
 0 UCUGCACU m7b Created no TS 0.008000 -0.220000
hsa-miR-497-5p gcatagTGCTGCTcccagg
 3
 CAGCAGCA m7b Disrupted 0.051000 -0.001000 5.080000
hsa-miR-558 gcatagtGCAGCTCccagg
 0 UGAGCUGC m7b Created -0.243000 -0.267000 -3.740000
hsa-miR-5591-5p gcatagtgcAGCTCCCAgg
 10
 UGGGAGCU m8a (m7a->m8a) -0.038000 -0.088000 -1.170000
hsa-miR-920 gcatagtgcAGCTCCCagg
 10
 GGGGAGCU m7b (m6b->m7b) -0.024000 -0.046000 -3.120000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.26854140T>A COSN9328881 AOCS-126-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-126-5p acttccAATAATagcattc
 2
 CAUUAUUA m6b Created 0.002000 0.198000 No effect
hsa-miR-4795-3p acttccAATAATAgcattc
 2
 AUAUUAUU m7b Created -0.050000 0.193000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.26854472G>A COSN7462675 8035567 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3187-3p tcagggggcATGGCCAcac
 0 UUGGCCAU m7b (m6b->m7b) no TS 0.081000 -2.990000
hsa-miR-4529-5p tcagggggcATGGCCacac
 0 AGGCCAUC m6b Created no TS 0.027000 -0.010000
hsa-miR-4701-5p tcagggggcGTGGCCAcac
 5
 UUGGCCAC m7b (m7b->m6b) -0.216000 -0.267000 No effect
hsa-miR-588 tcagggggcGTGGCCAcac
 5
 UUGGCCAC m7b (m7b->m6b) -0.197000 -0.267000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.26855485T>G COSN1204417 HX13T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
26852945 rs117796128 G
C hsa-miR-135b-3p
hsa-miR-4312
hsa-miR-8065
1
1
1
 atCCTACAAggcc
atcctACAAGGCc
aTCCTACAaggcc
 Created
Created
Created
N
N
N
 -0.058
-0.106
-0.058

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