SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_080649
Gene Symbol: APEX1
Description: Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 4, mRNA.
Gene Location: chr14(+):20923289-20925926
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr14:g.20457577C>A COSN1639515 RK082_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3659 ttaAACACTCttcagagaa
 2
 UGAGUGUU m7b (m7b->m6b) -0.248000 no TS 13.510000
hsa-miR-4427 ttaaacacTATTCAGAgaa
 0 UCUGAAUA m8a Created no TS -0.231000 -3.850000
hsa-miR-4709-3p ttaaacaCTCTTCAgagaa
 2
 UUGAAGAG m7b Disrupted -0.179000 no TS 8.290000
hsa-miR-5187-3p ttaaacactATTCAGagaa
 0 ACUGAAUC m6b Created no TS -0.080000 0.280000
hsa-miR-5585-3p ttaaacaCTATTCAGagaa
 0 CUGAAUAG m8a Created no TS -0.148000 -4.100000
hsa-miR-3659 ttaAACACTCttcagagaa
 2
 UGAGUGUU m7b (m7b->m6b) -0.248000 no TS 13.510000
hsa-miR-4427 ttaaacacTATTCAGAgaa
 0 UCUGAAUA m8a Created no TS -0.231000 -3.850000
hsa-miR-4709-3p ttaaacaCTCTTCAgagaa
 2
 UUGAAGAG m7b Disrupted -0.179000 no TS 8.290000
hsa-miR-5187-3p ttaaacactATTCAGagaa
 0 ACUGAAUC m6b Created no TS -0.080000 0.280000
hsa-miR-5585-3p ttaaacaCTATTCAGagaa
 0 CUGAAUAG m8a Created no TS -0.148000 -4.100000
hsa-miR-3659 ttaAACACTCttcagagaa
 2
 UGAGUGUU m7b (m7b->m6b) -0.248000 no TS 13.510000
hsa-miR-4427 ttaaacacTATTCAGAgaa
 0 UCUGAAUA m8a Created no TS -0.231000 -3.850000
hsa-miR-4709-3p ttaaacaCTCTTCAgagaa
 2
 UUGAAGAG m7b Disrupted -0.179000 no TS 8.290000
hsa-miR-5187-3p ttaaacactATTCAGagaa
 0 ACUGAAUC m6b Created no TS -0.080000 0.280000
hsa-miR-5585-3p ttaaacaCTATTCAGagaa
 0 CUGAAUAG m8a Created no TS -0.148000 -4.100000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.20457665A>G COSN8588396 3402_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3189-3p aagCCCAAGGttttttatt
 0 CCCUUGGG m7b (m6b->m7b) no TS -0.269000 -12.170000
hsa-miR-548ac aagcccaaGGTTTTTtatt
 0 CAAAAACC m7b Created -0.111000 -0.245000 -4.150000
hsa-miR-548c-3p aagcccaaGATTTTTtatt
 0 CAAAAAUC m7b Disrupted -0.067000 no TS 1.170000
hsa-miR-548d-3p aagcccaaGGTTTTTtatt
 0 CAAAAACC m7b Created -0.083000 -0.198000 -1.210000
hsa-miR-548h-3p aagcccaaGGTTTTTtatt
 0 CAAAAACC m7b Created -0.101000 -0.235000 -3.480000
hsa-miR-548z aagcccaaGGTTTTTtatt
 0 CAAAAACC m7b Created -0.101000 -0.235000 -3.480000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.20457694A>T COSN8140352 ASHPC_0009_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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