SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001142649
Gene Symbol: ANO5
Description: Homo sapiens anoctamin 5 (ANO5), transcript variant 2, mRNA.
Gene Location: chr11(+):22214721-22304913
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr11:g.22279930T>G COSN8217824 PCSI_0303_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr11:g.22280381T>C COSN6998422 8032817 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1253 agaattccTCTTCTCgaga
 2
 AGAGAAGA m7b Created -0.098000 -0.158000 -0.140000
hsa-miR-3125 agaaTTCCTCTtctcgaga
 4
 UAGAGGAA m7b Created -0.035000 -0.131000 -0.010000
hsa-miR-3916 agaaTTCCTCTTctcgaga
 4
 AAGAGGAA m8a Created -0.072000 -0.168000 -0.020000
hsa-miR-5197-3p agaattcCTCTTCTcgaga
 2
 AAGAAGAG m7b Created -0.275000 -0.312000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr11:g.22280505C>G COSN10083148 C0015T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr11:g.22280516C>A COSN8217825 PCSI_0002_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273e tcaggttcTCAAGCAAaga
 0 UUGCUUGA m8a Disrupted -0.183000 no TS 5.480000
hsa-miR-146a-5p tcagGTTCTCAagcaaaga
 2
 UGAGAACU m7a Disrupted -0.053000 no TS 0.020000
hsa-miR-146b-5p tcagGTTCTCAagcaaaga
 2
 UGAGAACU m7a Disrupted -0.053000 no TS 0.020000
hsa-miR-5687 tcagGTTCTAAagcaaaga
 0 UUAGAACG m7a Created no TS -0.050000 No effect
hsa-miR-589-5p tcaGGTTCTCAagcaaaga
 2
 UGAGAACC m8a Disrupted -0.244000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.22281037A>T COSN5903725 RK197_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1290 acatgcacaAAAATCCttg
 2
 UGGAUUUU m7b (m7b->m6c) 0.019000 no TS 0.020000
hsa-miR-2113 acatGCACAAAaatccttg
 2
 AUUUGUGC m7b Disrupted -0.030000 no TS No effect
hsa-miR-455-5p acatGCACATAaatccttg
 0 UAUGUGCC m7a Created no TS -0.039000 -0.110000
hsa-miR-5010-3p acatgCACAAAAatccttg
 2
 UUUUGUGU m7a Disrupted 0.054000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.22281129A>G COSN1524436 RK061_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1470 attagcactGGAGGGatat
 0 GCCCUCCG m6b Created no TS -0.097000 -7.700000
hsa-miR-1825 attaGCACTGGAgggatat
 0 UCCAGUGC m8a Created no TS -0.146000 -1.590000
hsa-miR-199a-5p attagCACTGGagggatat
 8
 CCCAGUGU m6b Created -0.212000 -0.251000 No effect
hsa-miR-199b-5p attagCACTGGagggatat
 8
 CCCAGUGU m6b Created -0.212000 -0.254000 No effect
hsa-miR-3925-3p attagcACTGGAGggatat
 0 ACUCCAGU m7b Created no TS -0.004000 -5.670000
hsa-miR-4473 attAGCACTAGagggatat
 0 CUAGUGCU m8a Disrupted -0.118000 no TS 0.320000
hsa-miR-642a-5p attagcactAGAGGGAtat
 0 GUCCCUCU m7b (m7b->m6c) -0.104000 no TS 0.640000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.22282374G>T COSN8439073 AOCS-148-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-500a-5p attaagaAAGGATTgtttt
 1
 UAAUCCUU m7b Disrupted -0.076000 no TS 2.030000
hsa-miR-501-5p attaagAAAGGATTgtttt
 0 AAUCCUUU m8a Disrupted -0.055000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.22282446T>G COSN10083149 C0100T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
22281124 rs78944911 G G hsa-miR-4473
hsa-miR-512-3p
hsa-miR-520f-3p
hsa-miR-6080
2
2
2
2
 ttattAGCACTAg
ttattAGCACTAg
ttattAGCACTAg
ttattaGCACTAG
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.118
-0.013
-0.038
-0.148
A hsa-miR-2053
hsa-miR-4255
hsa-miR-569
2
2
2
 ttATTAACActag
ttattAACACTAg
ttATTAACActag
 Created
Created
Created
N
N
N
 0.044
0.021
0.083

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