SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000031
Gene Symbol:	ALAD
Description:	Homo sapiens aminolevulinate dehydratase (ALAD), mRNA.
Gene Location:	chr9(-):116148591-116163618
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.113386563T>C			COSN14749612		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-224-3p	cccctCCATTTatgtgatg	1	AAAAUGGU	m6b	Disrupted	0.027000	0.044000	0.340000
hsa-miR-376c	cccctccaTCTATGTgatg	0	AACAUAGA	m7b	Created	no TS	-0.097000	-2.210000
hsa-miR-4534	cccCTCCATCtatgtgatg	0	GGAUGGAG	m7b	(m6c->m7b)	no TS	-0.180000	-1.920000
hsa-miR-4694-3p	ccccTCCATTTatgtgatg	1	CAAAUGGA	m7b	Disrupted	-0.076000	0.052000	9.980000
hsa-miR-522-3p	cccctCCATTTatgtgatg	1	AAAAUGGU	m6b	Disrupted	0.030000	0.047000	3.900000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.113386947A>G			COSN1372150		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273d	ggggaATGGGTTgtggatg	2	GAACCCAU	m7b	Created	-0.242000	-0.320000	-3.230000
hsa-miR-660-5p	ggggAATGGGTtgtggatg	0	UACCCAUU	m7b	Created	no TS	-0.045000	-0.020000
hsa-miR-1273d	ggggaATGGGTTgtggatg	0	GAACCCAU	m7b	Created	-0.242	-0.32	-3.23
hsa-miR-660-5p	ggggAATGGGTtgtggatg	0	UACCCAUU	m7b	Created	no TS	-0.045	-0.02

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.113387673C>T			COSN6376467		RK186_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-873-5p	gagggaGTTCCTGactgct	5	GCAGGAAC	m7b	Disrupted	-0.145000	no TS	0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
113386563	rs11556126	T	T	hsa-miR-224-3p hsa-miR-4694-3p hsa-miR-522-3p	1 1 1	ctCCATTTAtgtg cTCCATTTAtgtg ctCCATTTAtgtg	Disrupted Disrupted Disrupted	N N N	-0.017 -0.128 -0.017
			C	hsa-miR-376c-3p hsa-miR-4534 hsa-miR-8082	0	ctccaTCTATGTg CTCCATCtatgtg CTCCATCtatgtg	Created Created Created	N N N	-0.097 -0.18 -0.162

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