SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_005100
Gene Symbol: AKAP12
Description: Homo sapiens A kinase (PRKA) anchor protein 12 (AKAP12), transcript variant 1, mRNA.
Gene Location: chr6(+):151561133-151679694
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.151357245A>G ICGC_A157035A-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1227 tggagtgcaGTGGCACGat
0 CGUGCCAC m8a (m7b->m8a) no TS -0.051 -1.881
hsa-miR-1273g-3p tggagtGCAGTGGcacgat
0 ACCACUGC m7b Created -0.072 -0.177 -5.63
hsa-miR-25-3p tggaGTGCAATGgcacgat
0 CAUUGCAC m8a Disrupted 0.089 no TS 0.01
hsa-miR-32-5p tggaGTGCAATggcacgat
0 UAUUGCAC m7b Disrupted 0.089 no TS No effect
hsa-miR-363-3p tggaGTGCAATggcacgat
0 AAUUGCAC m7b Disrupted 0.07 no TS 0.01
hsa-miR-367-3p tggaGTGCAATggcacgat
0 AAUUGCAC m7b Disrupted 0.079 no TS 0.21
hsa-miR-4252 tggagtgCAGTGGCacgat
0 GGCCACUG m7b Created no TS -0.047 -2.03
hsa-miR-4793-3p tggAGTGCAGtggcacgat
0 UCUGCACU m7b (m6b->m7b) -0.119 -0.051 No effect
hsa-miR-92a-3p tggaGTGCAATggcacgat
0 UAUUGCAC m7b Disrupted 0.089 no TS 0.04
hsa-miR-92b-3p tggaGTGCAATggcacgat
0 UAUUGCAC m7b Disrupted 0.089 no TS 0.01

Mutation Mutation ID Sample Name Cancer Type
chr6:g.151357265C>T ICGC_A1570832-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4746-3p tcagctCACCGCaacctcc
0 AGCGGUGC m6b Disrupted -0.08 no TS 9.31
hsa-miR-4792 tcaGCTCACCGcaacctcc
0 CGGUGAGC m8a Disrupted -0.175 -0.141 1.25

Mutation Mutation ID Sample Name Cancer Type
chr6:g.151357288C>A 10_5013 6408 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
151357243 rs1134084 C C hsa-miR-25-3p
hsa-miR-32-5p
hsa-miR-363-3p
hsa-miR-367-3p
hsa-miR-4325
hsa-miR-7703
hsa-miR-92a-3p
hsa-miR-92b-3p
1
1
1
1
1
1
1
1
ggaGTGCAATggc
ggaGTGCAATggc
ggaGTGCAATggc
ggaGTGCAATggc
ggAGTGCAAtggc
gGAGTGCAAtggc
ggaGTGCAATggc
ggaGTGCAATggc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
0.089
0.089
0.07
0.079
0.033
-0.013
0.089
0.089
G hsa-miR-4436b-5p
hsa-miR-6509-3p
hsa-miR-6777-3p
1
1
1
ggAGTGGAAtggc
ggAGTGGAAtggc
gGAGTGGAatggc
Created
Created
Created
N
N
N
0.028
0.045
-0.012

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