SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000685
Gene Symbol: AGTR1
Description: Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA.
Gene Location: chr3(+):148415657-148460790
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742204A>T COSN9135363 AOCS-094-6-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-105-5p atgaGCATTTGctactttt
 0 UCAAAUGC m7b Created no TS -0.150000 -2.370000
hsa-miR-155-5p atgAGCATTAgctactttt
 0 UUAAUGCU m7b (m7b->m6b) -0.128000 no TS 6.100000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742345G>C COSN5038550 HCC162 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-22-5p cggctgctcGAAGAACaat
 0 AGUUCUUC m7b (m7b->m6c) -0.230000 -0.046000 2.920000
hsa-miR-432-5p cggctgCTCCAAGAacaat
 0 UCUUGGAG m8a Created no TS -0.338000 -18.980000
hsa-miR-22-5p cggctgctcGAAGAACaat
 0 AGUUCUUC m7b (m7b->m6c) -0.230000 -0.046000 2.920000
hsa-miR-432-5p cggctgCTCCAAGAacaat
 0 UCUUGGAG m8a Created no TS -0.338000 -18.980000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742550C>A COSN1269563 HCC121T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1537 gttttcgtgACGGTTTTca
 0 AAAACCGU m8a (m7b->m8a) no TS -0.162000 -0.160000
hsa-miR-1537 gttttcgtgACGGTTTTca
 0 AAAACCGU m8a (m7b->m8a) no TS -0.162 -0.16


Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742616T>C COSN8488453 783_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742711T>C COSN8488454 J46_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742712A>T COSN8488455 J46_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p agatggcTTTTTTGTataa
 0 ACAAAAAA m8a Created no TS 0.049000 -0.870000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.148742716G>T COSN9135364 AOCS-139-19-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p ggcttatTTGTATAatggt
 6
 CUAUACAA m7b Disrupted -0.160000 no TS 3.910000
hsa-let-7b-3p ggcttatTTGTATAatggt
 6
 CUAUACAA m7b Disrupted -0.160000 no TS 4.170000
hsa-let-7f-1-3p ggcttatTTGTATAatggt
 6
 CUAUACAA m7b Disrupted -0.160000 no TS 1.760000
hsa-let-7f-2-3p ggcttattTGTATAatggt
 6
 CUAUACAG m6b Disrupted -0.034000 no TS 3.020000
hsa-miR-1185-1-3p ggcttattTGTATAatggt
 6
 AUAUACAG m6b Disrupted -0.034000 no TS 0.030000
hsa-miR-1185-2-3p ggcttattTGTATAatggt
 6
 AUAUACAG m6b Disrupted -0.031000 no TS -0.190000
hsa-miR-300 ggcttatTTGTATAatggt
 8
 UAUACAAG m7a Disrupted -0.019000 no TS 1.380000
hsa-miR-3163 ggcttatTTTTATAatggt
 7
 UAUAAAAU m7a Created -0.069000 0.014000 -0.010000
hsa-miR-381 ggcttatTTGTATAatggt
 8
 UAUACAAG m7a Disrupted -0.029000 no TS 7.840000
hsa-miR-4666a-3p ggcttatTTGTATaatggt
 8
 CAUACAAU m6b Disrupted -0.020000 no TS 0.100000
hsa-miR-4789-5p ggcttattTGTATAatggt
 0 GUAUACAC m6b Disrupted -0.233000 -0.203000 No effect
hsa-miR-548c-3p ggcttATTTTTataatggt
 0 CAAAAAUC m6b Created no TS 0.096000 0.160000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
148742201 rs5186 A A hsa-miR-155-5p
hsa-miR-6847-3p
7
7
 atgAGCATTAgct
ATGAGCAttagct
 Disrupted
Disrupted
LT
N
 -0.128
-0.147

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