SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000025
Gene Symbol: ADRB3
Description: Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA.
Gene Location: chr8(-):37820513-37824184
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963044C>T COSN2275009 RK177_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2110 caccTTCCCCAgctacaaa
2
UUGGGGAA m7b Disrupted -0.131000 no TS 0.720000
hsa-miR-4271 cacCTTCCCCagctacaaa
2
GGGGGAAG m7b (m7b->m6c) -0.402000 no TS 0.920000
hsa-miR-4667-5p cacctTCCCCAGctacaaa
2
ACUGGGGA m7b Disrupted -0.246000 no TS 2.080000
hsa-miR-4700-5p cacctTCCCCAGctacaaa
2
UCUGGGGA m7b Disrupted -0.256000 no TS 2.180000
hsa-miR-4725-3p cacCTTCCCCAgctacaaa
2
UGGGGAAG m8a Disrupted -0.392000 no TS 2.090000
hsa-miR-4731-5p caccttCCCCAGCtacaaa
0 UGCUGGGG m7b Disrupted -0.622000 -0.278000 2.180000
hsa-miR-4747-5p caCCTTCCCTagctacaaa
2
AGGGAAGG m8a (m7b->m8a) -0.793000 -0.825000 -0.420000
hsa-miR-5196-5p caCCTTCCCTagctacaaa
2
AGGGAAGG m8a (m7b->m8a) -0.786000 -0.818000 -0.120000
hsa-miR-5584-5p caccTTCCCTagctacaaa
1
CAGGGAAA m6b Created 0.019000 -0.089000 -3.670000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963181T>C COSN7671605 ASHPC_0016_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3939 gtgtgtgTGCGCGTgtgtg
0 UACGCGCA m7b Created no TS -0.340000 1.810000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963640T>C COSN8518882 J10_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-578 cagggttcACAAGAAGgtg
0 CUUCUUGU m8a Created 0.000000 0.000000 -0.220000
hsa-miR-581 cagggttCACAAGAaggtg
0 UCUUGUGU m7a Created no TS -0.039000 -0.140000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963669C>T COSN4939897 PD4109a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-221-5p gaaggacttTGCCAGGgtt
0 ACCUGGCA m7b (m6b->m7b) no TS -0.162000 -1.020000
hsa-miR-3128 gaaggactTTGCCAGggtt
0 UCUGGCAA m7b Created no TS -0.090000 -4.890000


Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963782C>T COSN8518883 2173_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr8:g.37963787C>- ICGC_519943 TCGA-F4-6703-01A-11D-1835-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.37964016C>G COSN8315150 TCGA-AC-A3W6-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-299-5p agatgttttGTAAACCcca
0 UGGUUUAC m7b (m6b->m7b) no TS -0.152000 No effect
hsa-miR-520d-5p agatgtTTTGTAaacccca
0 CUACAAAG m6b Created no TS 0.048000 -0.480000
hsa-miR-524-5p agatgtTTTGTAaacccca
0 CUACAAAG m6b Created no TS 0.045000 No effect
hsa-miR-570-3p agaTGTTTTCtaaacccca
0 CGAAAACA m7b (m7b->m6c) -0.052000 0.011000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.37964094G>A ICGC_500238 TCGA-G4-6588-01A-11D-1771-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1291 cctgacgaCAGGGCCAtgt
0 UGGCCCUG m8a Created no TS -0.463 -0.05
hsa-miR-146b-3p cctgacgACAGGGCcatgt
0 UGCCCUGU m7b Created no TS -0.211 -0.44
hsa-miR-328 cctgacgacAGGGCCAtgt
0 CUGGCCCU m7b (m6b->m7b) no TS -0.195 No effect
hsa-miR-339-5p cctgacGACAGGGccatgt
0 UCCCUGUC m7b Created no TS -0.186 -0.11

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
37963044 rs201274361 C C hsa-miR-2110
hsa-miR-4271
hsa-miR-4667-5p
hsa-miR-4700-5p
hsa-miR-4725-3p
hsa-miR-4731-5p
hsa-miR-6780b-5p
hsa-miR-8089
2
2
2
2
2
2
2
2
cTTCCCCAgctac
CTTCCCCAgctac
ctTCCCCAGctac
ctTCCCCAGctac
CTTCCCCAgctac
cttCCCCAGCtac
CTTCCCCAgctac
ctTCCCCAGctac
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
-0.131
-0.402
-0.246
-0.256
-0.392
-0.344
-0.381
-0.246
A hsa-miR-4453
hsa-miR-450a-1-3p
hsa-miR-4538
hsa-miR-4747-5p
hsa-miR-5196-5p
2
2
2
2
2
cttcCCAAGCTAc
cTTCCCAAgctac
cttcCCAAGCTAc
CTTCCCAagctac
CTTCCCAagctac
Created
Created
Created
Created
Created
N
N
N
N
N
-0.4
-0.096
-0.411
-0.204
-0.203
37963047 rs199791905 C C hsa-miR-2110
hsa-miR-4271
hsa-miR-4667-5p
hsa-miR-4700-5p
hsa-miR-4725-3p
hsa-miR-4731-5p
hsa-miR-4747-5p
hsa-miR-5196-5p
hsa-miR-6780b-5p
hsa-miR-8089
2
2
2
2
2
2
2
2
2
2
caccTTCCCCAgc
cacCTTCCCCAgc
cacctTCCCCAGc
cacctTCCCCAGc
cacCTTCCCCAgc
caccttCCCCAGC
caCCTTCCCcagc
caCCTTCCCcagc
cacCTTCCCCAgc
cacctTCCCCAGc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
-0.131
-0.402
-0.246
-0.256
-0.392
-0.344
-0.22
-0.211
-0.381
-0.246
T hsa-miR-204-3p
hsa-miR-3153
hsa-miR-4646-5p
hsa-miR-4668-5p
hsa-miR-6730-5p
hsa-miR-6733-5p
hsa-miR-6739-5p
2
2
2
2
1
2
2
cacctTTCCCAGc
cacCTTTCCCAgc
cacctTTCCCAGc
caccTTTCCCAgc
cACCTTTCccagc
cacCTTTCCCAgc
cacCTTTCCCAgc
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
-0.217
-0.293
-0.208
-0.074
-0.115
-0.251
-0.283
37963063 rs200661120 C C hsa-miR-3927-3p
hsa-miR-4451
hsa-miR-4747-5p
hsa-miR-5196-5p
hsa-miR-6831-5p
7
6
7
7
7
ccTCTACCTtccc
cCTCTACCttccc
cctctaCCTTCCC
cctctaCCTTCCC
ccTCTACCTtccc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.141
-0.211
-0.283
-0.297
-0.141
T hsa-miR-4662a-3p
7
cctCTATCTTccc
Created
N
-0.096
37963177 rs201029362 -
C hsa-miR-3939
0 tgTGCGCGTgtgt
Unknown
N
-0.339
37963181 rs199958013 T
C hsa-miR-3939
0 tgtgTGCGCGTgt
Created
N
-0.34
37963536 rs199764189 T T hsa-miR-495-3p
hsa-miR-5688
hsa-miR-570-3p
4
4
9
cGTTTGTTttctt
cGTTTGTTttctt
cgttTGTTTTCtt
Disrupted
Disrupted
Disrupted
N
N
N
0.055
0.027
-0.016
37963537 rs200723701 G G hsa-miR-495-3p
hsa-miR-5688
hsa-miR-570-3p
4
4
12
ccGTTTGTTttct
ccGTTTGTTttct
ccgttTGTTTTCt
Disrupted
Disrupted
Disrupted
N
N
N
0.055
0.027
-0.016
37964051 rs201210193 C C hsa-miR-570-3p
5
gGTTTTCAccatc
Disrupted
N
0.029
T hsa-miR-548ac
hsa-miR-548ae
hsa-miR-548ah-3p
hsa-miR-548aj-3p
hsa-miR-548am-3p
hsa-miR-548aq-3p
hsa-miR-548d-3p
hsa-miR-548h-3p
hsa-miR-548j-3p
hsa-miR-548x-3p
hsa-miR-548z
4
5
5
5
5
5
4
4
5
5
4
GGTTTTTAccatc
gGTTTTTAccatc
gGTTTTTAccatc
gGTTTTTAccatc
gGTTTTTAccatc
gGTTTTTAccatc
GGTTTTTAccatc
GGTTTTTAccatc
gGTTTTTAccatc
gGTTTTTAccatc
GGTTTTTAccatc
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
-0.049
0.079
0.079
0.079
0.079
0.079
-0.049
-0.049
0.076
0.079
-0.049

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