SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000024
Gene Symbol:	ADRB2
Description:	Homo sapiens adrenergic, beta-2-, receptor, surface (ADRB2), mRNA.
Gene Location:	chr5(+):148206155-148208197
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.148828580C>T			COSN2076160		RK007_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1178	ttgttttccTGAGCAAagt	0	UUGCUCAC	m7a	(m6b->m7a)	no TS	-0.156000	-11.230000
hsa-miR-3664-3p	ttgtttTCCTGAGcaaagt	0	UCUCAGGA	m7b	Created	no TS	-0.251000	-3.100000
hsa-miR-423-3p	ttgttttcCCGAGCaaagt	0	AGCUCGGU	m6b	Disrupted	-0.308000	no TS	16.960000
hsa-miR-425-3p	ttgttTTCCCGAgcaaagt	0	AUCGGGAA	m7b	Disrupted	-0.313000	no TS	2.770000
hsa-miR-4518	ttgttttCCTGAGCaaagt	0	GCUCAGGG	m7a	Created	NA	NA	-4.020000
hsa-miR-4668-5p	ttgTTTTCCCgagcaaagt	0	AGGGAAAA	m7b	(m7b->m6b)	-0.116000	no TS	3.040000
hsa-miR-873-5p	ttgttTTCCTGagcaaagt	0	GCAGGAAC	m6b	Created	no TS	-0.106000	-0.230000
hsa-miR-1178	ttgttttccTGAGCAAagt	0	UUGCUCAC	m7a	(m6b->m7a)	no TS	-0.156	-11.23
hsa-miR-3664-3p	ttgtttTCCTGAGcaaagt	0	UCUCAGGA	m7b	Created	no TS	-0.251	-3.1
hsa-miR-423-3p	ttgttttcCCGAGCaaagt	0	AGCUCGGU	m6b	Disrupted	-0.308	no TS	16.96
hsa-miR-425-3p	ttgttTTCCCGAgcaaagt	0	AUCGGGAA	m7b	Disrupted	-0.313	no TS	2.77
hsa-miR-4518	ttgttttCCTGAGCaaagt	0	GCUCAGGG	m7a	Created	NA	NA	-4.02
hsa-miR-4668-5p	ttgTTTTCCCgagcaaagt	0	AGGGAAAA	m7b	(m7b->m6b)	-0.116	no TS	3.04
hsa-miR-873-5p	ttgttTTCCTGagcaaagt	0	GCAGGAAC	m6b	Created	no TS	-0.106	-0.23

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
148828356	rs76224012	A	A	hsa-miR-7154-5p hsa-miR-8060	2 2	attTTCATGActt attTTCATGActt	Disrupted Disrupted	N N	-0.153 -0.051
			C	hsa-miR-873-5p	2	attTTCCTGActt	Created	N	-0.096
148828581	rs150245162	G	G	hsa-miR-423-3p hsa-miR-425-3p	0	tttcCCGAGCAaa tTTCCCGAgcaaa	Disrupted Disrupted	N N	-0.308 -0.313
			A	hsa-miR-1273e hsa-miR-3153 hsa-miR-450a-1-3p hsa-miR-4668-5p hsa-miR-6733-5p hsa-miR-6739-5p hsa-miR-6885-3p	0	tttccCAAGCAAa TTTCCCAagcaaa tTTCCCAAgcaaa TTTCCCAagcaaa TTTCCCAagcaaa TTTCCCAagcaaa tttcccAAGCAAA	Created Created Created Created Created Created Created	N N N N N N N	-0.14 -0.093 -0.176 -0.143 -0.103 -0.1 -0.051

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