SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_005159 |
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Gene Symbol: | ACTC1 |
Description: | Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA. |
Gene Location: | chr15(-):35080296-35087927 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.34788314T>C | COSN5396413 | RK060_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-2682-3p |
cagAAGAGGCaagcaccca |
0 | CGCCUCUU | m7b | (m6c->m7b) | no TS | -0.325000 |
-2.280000 |
|
hsa-miR-3152-5p |
cagaaGAGGCAAgcaccca |
0 | AUUGCCUC | m7b | Created | no TS | -0.225000 |
-1.840000 |
|
hsa-miR-4327 |
cagaagagGCAAGCaccca |
0 | GGCUUGCA | m6b | Created | no TS | -0.160000 |
-2.990000 |
|
hsa-miR-4777-3p |
cagaaGAGGTAagcaccca |
2 |
AUACCUCA | m6b | Disrupted | -0.140000 | no TS |
0.020000 |
|
hsa-miR-636 |
cagaagaggCAAGCACcca |
0 | UGUGCUUG | m7b | (m6b->m7b) | no TS | -0.130000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.34788630A>G | COSN5173601 | PD3905a | [breast][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1282 |
ggtGCAAACGttattgtac |
0 | UCGUUUGC | m7b | (m6c->m7b) | no TS | -0.261000 |
-0.860000 |
|
hsa-miR-33a-3p |
ggtgcAAACATTattgtac |
2 |
CAAUGUUU | m7b | Disrupted | 0.050000 | no TS |
0.240000 |
|
hsa-miR-409-3p |
ggtgcaAACATTattgtac |
2 |
GAAUGUUG | m6b | Disrupted | 0.044000 | no TS |
0.130000 |
|
hsa-miR-4307 |
ggtgcAAACATTattgtac |
0 | AAUGUUUU | m7a | Disrupted | 0.071000 | 0.071000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.34789004C>T | COSN7043523 | 8057574 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-944 |
taaAATAATTTttctaact |
0 | AAAUUAUU | m8a | Created | no TS | 0.061000 |
-0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.34789988A>G | 9_21084 | CRC-3-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-200a-5p |
aattgaaTAAGATagttct |
8 |
CAUCUUAC | m6b | Disrupted | -0.033 | no TS | No effect | |
hsa-miR-200b-5p |
aattgaaTAAGATagttct |
8 |
CAUCUUAC | m6b | Disrupted | -0.039 | no TS |
0.05 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.34790156C>T | COSN5753952 | HCC159 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-302b-5p |
gagcattGTTAAAGTtcag |
1 |
ACUUUAAC | m8a | Created | -0.101000 | -0.184000 |
-0.030000 |
|
hsa-miR-302d-5p |
gagcattGTTAAAGTtcag |
1 |
ACUUUAAC | m8a | Created | -0.110000 | -0.203000 |
-1.460000 |
|
hsa-miR-514a-3p |
gagcatTGTCAAagttcag |
0 | AUUGACAC | m6b | Disrupted | -0.056000 | no TS |
0.520000 |
|
hsa-miR-514b-3p |
gagcatTGTCAAagttcag |
0 | AUUGACAC | m6b | Disrupted | -0.056000 | no TS |
0.710000 |
|
hsa-miR-302b-5p |
gagcattGTTAAAGTtcag |
1 |
ACUUUAAC | m8a | Created | -0.101000 | -0.184000 |
-0.030000 |
|
hsa-miR-302d-5p |
gagcattGTTAAAGTtcag |
1 |
ACUUUAAC | m8a | Created | -0.110000 | -0.203000 |
-1.460000 |
|
hsa-miR-514a-3p |
gagcatTGTCAAagttcag |
0 | AUUGACAC | m6b | Disrupted | -0.056000 | no TS |
0.520000 |
|
hsa-miR-514b-3p |
gagcatTGTCAAagttcag |
0 | AUUGACAC | m6b | Disrupted | -0.056000 | no TS |
0.710000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr15:g.34790357G>A | COSN5753954 | HCC174 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3145-5p |
atgcttcTTGGAGTcttcc |
10 |
AACUCCAA | m7b | Disrupted | -0.353000 | -0.196000 | No effect |
hsa-miR-3653 |
atgCTTCTTAGagtcttcc |
0 | CUAAGAAG | m8a | Created | no TS | -0.053000 |
-0.190000 |
hsa-miR-5695 |
atgcttCTTGGAGTcttcc |
8 |
ACUCCAAG | m8a | Disrupted | -0.204000 | no TS |
3.040000 |
hsa-miR-3145-5p |
atgcttcTTGGAGTcttcc |
10 |
AACUCCAA | m7b | Disrupted | -0.353000 | -0.196000 | No effect |
hsa-miR-3653 |
atgCTTCTTAGagtcttcc |
0 | CUAAGAAG | m8a | Created | no TS | -0.053000 |
-0.190000 |
hsa-miR-5695 |
atgcttCTTGGAGTcttcc |
8 |
ACUCCAAG | m8a | Disrupted | -0.204000 | no TS |
3.040000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
34788730 | rs533021 | A | A |
hsa-miR-4680-5p hsa-miR-520f-5p hsa-miR-618 |
4 6 6 |
gagtttAGAGTTC gagTTTAGAGttc gagttTAGAGTTc |
Disrupted Disrupted Disrupted |
N N N |
-0.17 -0.053 -0.098 |
G |
hsa-miR-3145-5p hsa-miR-519d-5p |
6 6 |
gagtTTGGAGTtc gagTTTGGAGttc |
Created Created |
N N |
-0.148 -0.082 |
|||
34789373 | rs589759 | A | G |
hsa-miR-4684-5p hsa-miR-520f-5p |
0 |
gtctTAGAGAAtg gtcTTAGAGAatg |
Created Created |
N N |
0.051 0.045 |
A |
hsa-miR-208a-3p hsa-miR-208b-3p hsa-miR-302b-5p hsa-miR-302d-5p hsa-miR-3658 hsa-miR-499a-5p |
0 |
GTCTTAAagaatg GTCTTAAagaatg gtcTTAAAGAatg gtcTTAAAGAatg gTCTTAAAgaatg GTCTTAAagaatg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
0.021 0.021 0.121 0.121 0.117 0.03 |
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34790275 | rs149031785 | A | |||||||
T |
hsa-miR-3653 |
14 |
gCTTCTTAtattt |
Created |
N |
-0.12 |