SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005159
Gene Symbol: ACTC1
Description: Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA.
Gene Location: chr15(-):35080296-35087927
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.34788314T>C COSN5396413 RK060_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-3p cagAAGAGGCaagcaccca
 0 CGCCUCUU m7b (m6c->m7b) no TS -0.325000 -2.280000
hsa-miR-3152-5p cagaaGAGGCAAgcaccca
 0 AUUGCCUC m7b Created no TS -0.225000 -1.840000
hsa-miR-4327 cagaagagGCAAGCaccca
 0 GGCUUGCA m6b Created no TS -0.160000 -2.990000
hsa-miR-4777-3p cagaaGAGGTAagcaccca
 2
 AUACCUCA m6b Disrupted -0.140000 no TS 0.020000
hsa-miR-636 cagaagaggCAAGCACcca
 0 UGUGCUUG m7b (m6b->m7b) no TS -0.130000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.34788630A>G COSN5173601 PD3905a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1282 ggtGCAAACGttattgtac
 0 UCGUUUGC m7b (m6c->m7b) no TS -0.261000 -0.860000
hsa-miR-33a-3p ggtgcAAACATTattgtac
 2
 CAAUGUUU m7b Disrupted 0.050000 no TS 0.240000
hsa-miR-409-3p ggtgcaAACATTattgtac
 2
 GAAUGUUG m6b Disrupted 0.044000 no TS 0.130000
hsa-miR-4307 ggtgcAAACATTattgtac
 0 AAUGUUUU m7a Disrupted 0.071000 0.071000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.34789004C>T COSN7043523 8057574 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-944 taaAATAATTTttctaact
 0 AAAUUAUU m8a Created no TS 0.061000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.34789988A>G 9_21084 CRC-3-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200a-5p aattgaaTAAGATagttct
 8
 CAUCUUAC m6b Disrupted -0.033 no TS No effect
hsa-miR-200b-5p aattgaaTAAGATagttct
 8
 CAUCUUAC m6b Disrupted -0.039 no TS 0.05

Mutation Mutation ID Sample Name Cancer Type
chr15:g.34790156C>T COSN5753952 HCC159 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302b-5p gagcattGTTAAAGTtcag
 1
 ACUUUAAC m8a Created -0.101000 -0.184000 -0.030000
hsa-miR-302d-5p gagcattGTTAAAGTtcag
 1
 ACUUUAAC m8a Created -0.110000 -0.203000 -1.460000
hsa-miR-514a-3p gagcatTGTCAAagttcag
 0 AUUGACAC m6b Disrupted -0.056000 no TS 0.520000
hsa-miR-514b-3p gagcatTGTCAAagttcag
 0 AUUGACAC m6b Disrupted -0.056000 no TS 0.710000
hsa-miR-302b-5p gagcattGTTAAAGTtcag
 1
 ACUUUAAC m8a Created -0.101000 -0.184000 -0.030000
hsa-miR-302d-5p gagcattGTTAAAGTtcag
 1
 ACUUUAAC m8a Created -0.110000 -0.203000 -1.460000
hsa-miR-514a-3p gagcatTGTCAAagttcag
 0 AUUGACAC m6b Disrupted -0.056000 no TS 0.520000
hsa-miR-514b-3p gagcatTGTCAAagttcag
 0 AUUGACAC m6b Disrupted -0.056000 no TS 0.710000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.34790357G>A COSN5753954 HCC174 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3145-5p atgcttcTTGGAGTcttcc
 10
 AACUCCAA m7b Disrupted -0.353000 -0.196000 No effect
hsa-miR-3653 atgCTTCTTAGagtcttcc
 0 CUAAGAAG m8a Created no TS -0.053000 -0.190000
hsa-miR-5695 atgcttCTTGGAGTcttcc
 8
 ACUCCAAG m8a Disrupted -0.204000 no TS 3.040000
hsa-miR-3145-5p atgcttcTTGGAGTcttcc
 10
 AACUCCAA m7b Disrupted -0.353000 -0.196000 No effect
hsa-miR-3653 atgCTTCTTAGagtcttcc
 0 CUAAGAAG m8a Created no TS -0.053000 -0.190000
hsa-miR-5695 atgcttCTTGGAGTcttcc
 8
 ACUCCAAG m8a Disrupted -0.204000 no TS 3.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
34788730 rs533021 A A hsa-miR-4680-5p
hsa-miR-520f-5p
hsa-miR-618
4
6
6
 gagtttAGAGTTC
gagTTTAGAGttc
gagttTAGAGTTc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.17
-0.053
-0.098
G hsa-miR-3145-5p
hsa-miR-519d-5p
6
6
 gagtTTGGAGTtc
gagTTTGGAGttc
 Created
Created
N
N
 -0.148
-0.082
34789373 rs589759 A G hsa-miR-4684-5p
hsa-miR-520f-5p
0 gtctTAGAGAAtg
gtcTTAGAGAatg
 Created
Created
N
N
 0.051
0.045
A hsa-miR-208a-3p
hsa-miR-208b-3p
hsa-miR-302b-5p
hsa-miR-302d-5p
hsa-miR-3658
hsa-miR-499a-5p
0 GTCTTAAagaatg
GTCTTAAagaatg
gtcTTAAAGAatg
gtcTTAAAGAatg
gTCTTAAAgaatg
GTCTTAAagaatg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.021
0.021
0.121
0.121
0.117
0.03
34790275 rs149031785 A
T hsa-miR-3653
14
 gCTTCTTAtattt
 Created
N
 -0.12

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