SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_020469
Gene Symbol:	ABO
Description:	Homo sapiens ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (ABO), mRNA.
Gene Location:	chr9(-):136130562-136150630
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.133255299G>C			COSN1374717		HX16T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1908	cgcccttCCCGCCacagaa	0	CGGCGGGG	m6b	Created	-1.604000	-1.844000	-0.150000
hsa-miR-4743	cgccctTCCGGCCAcagaa	0	UGGCCGGA	m8a	Disrupted	-0.560000	no TS	19.300000
hsa-miR-4747-5p	cgcCCTTCCCgccacagaa	0	AGGGAAGG	m7b	(m6c->m7b)	no TS	-0.111000	-10.620000
hsa-miR-5196-5p	cgcCCTTCCCgccacagaa	0	AGGGAAGG	m7b	(m6c->m7b)	no TS	-0.102000	-0.010000
hsa-miR-663a	cgcccttCCCGCCacagaa	0	AGGCGGGG	m6b	Created	-1.615000	-1.855000	0.070000
hsa-miR-663b	cgcccttccGGCCACagaa	0	GGUGGCCC	m6b	Disrupted	-0.186000	no TS	12.570000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.133255639T>A			COSN1374718		HCC101T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-18a-3p	tgggAGGGCAGccggcagc	0	ACUGCCCU	m7b	Created	no TS	-0.062000	5.350000
hsa-miR-4290	tgGGAGGGCAgccggcagc	2	UGCCCUCC	m8a	(m7b->m8a)	-0.187000	-0.400000	-0.630000
hsa-miR-4687-5p	tggGAGGGCTGccggcagc	2	CAGCCCUC	m8a	Disrupted	-0.105000	no TS	0.700000
hsa-miR-18a-3p	tgggAGGGCAGccggcagc	0	ACUGCCCU	m7b	Created	no TS	-0.062000	5.350000
hsa-miR-4290	tgGGAGGGCAgccggcagc	2	UGCCCUCC	m8a	(m7b->m8a)	-0.187000	-0.400000	-0.630000
hsa-miR-4687-5p	tggGAGGGCTGccggcagc	2	CAGCCCUC	m8a	Disrupted	-0.105000	no TS	0.700000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
133255294	rs111926917	-	C	hsa-miR-134-3p hsa-miR-4652-3p hsa-miR-4743-3p hsa-miR-663b hsa-miR-7108-5p hsa-miR-7114-5p	1 0 0 0 0 1	cggCCACAGAaac cggccACAGAAAc cggccACAGAAAc cGGCCACAgaaac cGGCCACAgaaac cggCCACAGAaac	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	-0.115 -0.006 -0.014 -0.186 -0.244 -0.123
			T	hsa-miR-4482-3p hsa-miR-7159-3p	0	cggccATAGAAAc cggcCATAGAAAc	Unknown Unknown	N N	0.026 -0.122
133255299	rs62641787	-	G	hsa-miR-4743-5p hsa-miR-6125 hsa-miR-663b hsa-miR-7108-5p	0	cctTCCGGCCAca CCTTCCGgccaca ccttccGGCCACA ccttccGGCCACA	Unknown Unknown Unknown Unknown	N N N N	-0.56 -0.194 -0.186 -0.244
			C	hsa-miR-1908-5p hsa-miR-4747-5p hsa-miR-5196-5p hsa-miR-663a hsa-miR-6787-5p	0	ccttCCCGCCAca CCTTCCCgccaca CCTTCCCgccaca ccttCCCGCCAca ccttCCCGCCAca	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.24 -0.111 -0.102 -0.24 -0.233
133255354	rs187099314	-	G	hsa-miR-1908-5p hsa-miR-4706 hsa-miR-4749-5p hsa-miR-663a hsa-miR-6777-5p hsa-miR-6787-5p hsa-miR-6889-5p	1 1 1 1 1 1 1	ctCCCCGCCAcag cTCCCCGCcacag cTCCCCGCcacag ctCCCCGCCAcag CTCCCCGccacag ctCCCCGCCAcag CTCCCCGccacag	Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N	-0.527 -0.271 -0.234 -0.527 -0.223 -0.538 -0.223
			A	hsa-miR-1343-5p hsa-miR-3150a-3p hsa-miR-3175 hsa-miR-491-5p hsa-miR-541-3p hsa-miR-654-5p hsa-miR-6763-5p hsa-miR-6769a-5p hsa-miR-6769b-5p hsa-miR-6825-5p hsa-miR-92a-2-5p hsa-miR-939-5p	1 1 1 1 1 1 1 1 1 1 1 1	CTCCCCAccacag CTCCCCAccacag CTCCCCAccacag cTCCCCACcacag ctcCCCACCAcag ctcCCCACCAcag CTCCCCAccacag ctcCCCACCAcag ctcCCCACCAcag CTCCCCAccacag ctCCCCACCAcag CTCCCCAccacag	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N N N	-0.147 -0.125 -0.148 -0.151 -0.154 -0.161 -0.143 -0.167 -0.167 -0.207 -0.426 -0.143
133255356	rs201070878	-	-	hsa-miR-149-3p hsa-miR-1908-5p hsa-miR-4706 hsa-miR-4728-5p hsa-miR-4749-5p hsa-miR-663a hsa-miR-6777-5p hsa-miR-6785-5p hsa-miR-6787-5p hsa-miR-6825-5p hsa-miR-6883-5p hsa-miR-6889-5p	1 1 1 1 1 1 1 1 1 1 1 1	CCCTCCCcgccac ccctCCCCGCCAc cccTCCCCGCcac CCCTCCCcgccac cccTCCCCGCcac ccctCCCCGCCAc ccCTCCCCGccac CCCTCCCcgccac ccctCCCCGCCAc cCCTCCCCgccac CCCTCCCcgccac ccCTCCCCGccac	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N N N	-0.189 -0.527 -0.271 -0.152 -0.234 -0.527 -0.223 -0.208 -0.538 -0.174 -0.189 -0.223
			T	hsa-miR-25-5p hsa-miR-4730 hsa-miR-4779 hsa-miR-658 hsa-miR-765	1 1 1 1 1	ccctcCTCCGCCAc ccctccTCCGCCAc CCCTCCTccgccac ccctCCTCCGCcac ccCTCCTCCgccac	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.503 -0.237 -0.177 -0.278 -0.141
133255506	rs7469795	G	A	hsa-miR-1343-5p hsa-miR-3150a-3p hsa-miR-3175 hsa-miR-491-5p hsa-miR-541-3p hsa-miR-654-5p hsa-miR-6763-5p hsa-miR-6769a-5p hsa-miR-6769b-5p hsa-miR-6825-5p hsa-miR-92a-2-5p hsa-miR-939-5p	0	CTCCCCAccacag CTCCCCAccacag CTCCCCAccacag cTCCCCACcacag ctcCCCACCAcag ctcCCCACCAcag CTCCCCAccacag ctcCCCACCAcag ctcCCCACCAcag CTCCCCAccacag ctCCCCACCAcag CTCCCCAccacag	Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N	-0.128 -0.1 -0.129 -0.135 -0.147 -0.154 -0.118 -0.16 -0.16 -0.207 -0.406 -0.128
			G	hsa-miR-1908-5p hsa-miR-4706 hsa-miR-4749-5p hsa-miR-663a hsa-miR-6777-5p hsa-miR-6787-5p hsa-miR-6889-5p	0	ctCCCCGCCAcag cTCCCCGCcacag cTCCCCGCcacag ctCCCCGCCAcag CTCCCCGccacag ctCCCCGCCAcag CTCCCCGccacag	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.516 -0.252 -0.215 -0.537 -0.198 -0.527 -0.236

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