SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002313
Gene Symbol: ABLIM1
Description: Homo sapiens actin binding LIM protein 1 (ABLIM1), transcript variant 2, mRNA.
Gene Location: chr10(-):116190868-116418058
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr10:g.114431367A>G COSN1472115 RK046_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-543 tgaaagcaAATGTTTagaa
 4
 AAACAUUC m7a Disrupted 0.047000 0.047000 No effect
hsa-miR-543 tgaaagcaAATGTTTagaa
 0 AAACAUUC m7a Disrupted 0.047 0.047 No effect

Mutation Mutation ID Sample Name Cancer Type
chr10:g.114431540T>C COSN10060255 C0021T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4323 ctttTGGGGCTttatgtac
 4
 CAGCCCCA m7b Created -0.090000 -0.408000 -0.170000
hsa-miR-548aa cttttggGGTTTTatgtac
 0 AAAAACCA m6b Disrupted -0.001000 0.001000 0.730000
hsa-miR-548ap-3p cttttggGGTTTTatgtac
 0 AAAAACCA m6b Disrupted -0.001000 0.001000 0.650000
hsa-miR-548as-3p cttttgGGGTTTTAtgtac
 0 UAAAACCC m8a Disrupted -0.170000 no TS 1.850000
hsa-miR-548at-3p cttttggGGTTTTatgtac
 0 CAAAACCG m6b Disrupted -0.045000 no TS 1.180000
hsa-miR-548t-3p cttttggGGTTTTatgtac
 0 AAAAACCA m6b Disrupted -0.001000 0.001000 0.730000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.114432012A>T COSN8149633 ASHPC_0011_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130b-5p agaaGAAAGAGaaaccttc
 7
 ACUCUUUC m7b Disrupted -0.022000 0.073000 0.060000
hsa-miR-4753-3p agaagAAAGAGAAaccttc
 7
 UUCUCUUU m8a Disrupted -0.148000 -0.170000 0.010000
hsa-miR-4768-5p agaagaaAGAGAAaccttc
 9
 AUUCUCUC m6b Disrupted -0.055000 -0.089000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr10:g.114433318T>A 11_66 2542 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3129-3p ctgcacatTTAGTTaaact
 4
 AAACUAAU m6b Disrupted 0.233 0.111 No effect
hsa-miR-5583-5p ctgcacatTTAGTTaaact
 4
 AAACUAAU m6b Disrupted 0.223 0.104 No effect


Mutation Mutation ID Sample Name Cancer Type
chr10:g.114433995A>T COSN6057432 RK220_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.114434171G>C COSN8530229 AOCS-105-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p tagcctTTGCTGTctcagt
 0 CACAGCAA m7b Created no TS 0.069000 -0.020000
hsa-miR-4524a-3p tagcctttgCTGTCTCAgt
 3
 UGAGACAG m8a (m7a->m8a) 0.025000 0.016000 0.860000
hsa-miR-4524b-3p tagcctttgCTGTCTCagt
 0 GAGACAGG m7a (m6a->m7a) NA NA No effect
hsa-miR-545-3p tagccTTTGCTGtctcagt
 5
 UCAGCAAA m7b Created -0.038000 0.087000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.114434534A>G COSN1112769 HX13T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2054 taggATTACAagctgtctc
 2
 CUGUAAUA m6b Disrupted 0.123000 no TS 3.460000
hsa-miR-2054 taggATTACAagctgtctc
 0 CUGUAAUA m6b Disrupted 0.123 no TS 3.46

Mutation Mutation ID Sample Name Cancer Type
chr10:g.114435208A>T COSN8919043 SS6003149 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1264 aggaAAGACTTGtttttct
 0 CAAGUCUU m8a Created no TS -0.044000 -0.020000
hsa-miR-511 aggAAAGACAtgtttttct
 0 GUGUCUUU m7b (m7b->m6c) 0.033000 0.005000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
114431542 rs117804319 G G hsa-miR-548aa
hsa-miR-548ap-3p
hsa-miR-548as-3p
hsa-miR-548at-3p
hsa-miR-548ay-3p
hsa-miR-548t-3p
hsa-miR-6771-3p
2
2
2
2
2
2
4
 ttttggGGTTTTA
ttttggGGTTTTA
ttttgGGGTTTTA
ttttggGGTTTTA
ttttggGGTTTTA
ttttggGGTTTTA
ttttGGGGTTTta
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.002
-0.002
-0.17
-0.045
-0.038
-0.002
-0.232
A hsa-miR-3145-5p
hsa-miR-519d-5p
hsa-miR-548a-3p
hsa-miR-548ar-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-5582-3p
3
3
2
2
2
2
2
2
 ttTTGGAGTttta
tTTTGGAGtttta
ttttggAGTTTTA
ttttggAGTTTTA
ttttggAGTTTTA
ttttggAGTTTTA
ttttggAGTTTTA
ttttggAGTTTTA
 Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
 -0.218
-0.154
0.04
0.047
0.04
0.04
0.04
0.043

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