SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005845
Gene Symbol:	ABCC4
Description:	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), transcript variant 2, mRNA.
Gene Location:	chr13(-):95672082-95953687
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.95020479A>T			COSN5349621		RK088_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-181a-5p	tgtTGAATGTatcaacaaa	0	AACAUUCA	m7b	(m6c->m7b)	no TS	-0.084000	-0.740000
hsa-miR-181b-5p	tgtTGAATGTatcaacaaa	0	AACAUUCA	m7b	(m6c->m7b)	no TS	-0.063000	-8.060000
hsa-miR-181c-5p	tgtTGAATGTatcaacaaa	0	AACAUUCA	m7b	(m6c->m7b)	no TS	-0.084000	-0.130000
hsa-miR-181d	tgtTGAATGTatcaacaaa	0	AACAUUCA	m7b	(m6c->m7b)	no TS	-0.063000	-4.040000
hsa-miR-4262	tgtTGAATGTatcaacaaa	0	GACAUUCA	m7b	(m6c->m7b)	no TS	-0.095000	-0.270000
hsa-miR-664-3p	tgttgAATGAATcaacaaa	2	UAUUCAUU	m7b	Disrupted	0.109000	0.082000	0.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.95020602G>T			COSN8587896		951_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4327	ttatTGCAAGCattgacta	3	GGCUUGCA	m7b	Disrupted	-0.293000	no TS	0.220000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.95020948A>G			COSN8426895		AOCS-091-3-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130b-5p	atatgttctGAAAGAGaag	5	ACUCUUUC	m7b	(m6b->m7b)	-0.003000	-0.145000	-1.220000
hsa-miR-30a-3p	atatgttCTGAAAGagaag	7	CUUUCAGU	m7a	Created	-0.140000	-0.140000	-0.010000
hsa-miR-30d-3p	atatgttCTGAAAGagaag	7	CUUUCAGU	m7a	Created	-0.159000	-0.159000	-0.040000
hsa-miR-30e-3p	atatgttCTGAAAGagaag	7	CUUUCAGU	m7a	Created	-0.168000	-0.168000	No effect
hsa-miR-4773	ataTGTTCTGaaagagaag	5	CAGAACAG	m7a	(m6b->m7a)	-0.056000	no TS	No effect
hsa-miR-5687	atatGTTCTAAaagagaag	5	UUAGAACG	m7a	Disrupted	-0.087000	no TS	0.010000
hsa-miR-589-3p	ataTGTTCTGAaagagaag	0	UCAGAACA	m8a	Created	no TS	-0.218000	-2.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.95020989A>G			COSN8587897		J1_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.95021070G>T			COSN8426896		AOCS-116-1-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-337-3p	aaccaATAGGAacaacaaa	5	CUCCUAUA	m6b	Disrupted	-0.063000	no TS	6.430000
hsa-miR-4326	aaccaatAGGAACAacaaa	2	UGUUCCUC	m7a	Disrupted	-0.108000	no TS	0.250000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
95020604	rs9516520	A	A	hsa-miR-106a-3p hsa-miR-4327	3 3	tATTGCAAgcatt tatTGCAAGCAtt	Disrupted Disrupted	N N	-0.028 -0.293
95020881	rs4148553	G	G	hsa-miR-205-5p hsa-miR-3657 hsa-miR-4669	5 5 5	acTGAAGGAcaca actgaaGGACACA actgaaGGACACA	Disrupted Disrupted Disrupted	N N N	-0.047 -0.116 -0.131
			A	hsa-miR-30a-3p hsa-miR-30d-3p hsa-miR-30e-3p hsa-miR-4711-3p hsa-miR-511-5p hsa-miR-6830-3p	2 2 2 3 4 3	ACTGAAAgacaca ACTGAAAgacaca ACTGAAAgacaca actgaAAGACACA actgAAAGACAca actGAAAGACAca	Created Created Created Created Created Created	N N N N N N	-0.01 -0.01 -0.019 -0.151 0.007 -0.133
95021445	rs141863654	G	A	hsa-miR-4272 hsa-miR-539-5p hsa-miR-6074	1 1 1	TTGAATAtttctc ttgaatATTTCTC tTGAATATttctc	Created Created Created	N N N	-0.039 -0.111 -0.16
			G	hsa-miR-181a-5p hsa-miR-181b-5p hsa-miR-181c-5p hsa-miR-181d-5p hsa-miR-4262 hsa-miR-494-3p hsa-miR-543	1 1 1 1 1 1 1	tTGAATGTttctc tTGAATGTttctc tTGAATGTttctc tTGAATGTttctc tTGAATGTttctc ttgaATGTTTCtc ttGAATGTTtctc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.16 -0.16 -0.151 -0.16 -0.16 -0.112 -0.125

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