SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000927
Gene Symbol: ABCB1
Description: Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), mRNA.
Gene Location: chr7(-):87133178-87342639
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Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.87503884A>C COSN15377497 0091_CRUK_PC_0091_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4795-3p gtgtctATAATAaaactaa
7
AUAUUAUU m6b Disrupted -0.014000 no TS 2.510000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.87503969T>C COSN8806315 SS6003314 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2110 tttatatTTCCCCAtttgg
0 UUGGGGAA m7b Created no TS -0.257000 -1.750000
hsa-miR-3153 tttataTTTCCCCatttgg
0 GGGGAAAG m7a Created -0.134000 no TS 1.440000
hsa-miR-4271 tttatatTTCCCCatttgg
0 GGGGGAAG m6b Created no TS -0.186000 -2.920000
hsa-miR-4668-5p tttataTTTTCCCatttgg
0 AGGGAAAA m7b Disrupted -0.346000 no TS 3.120000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
87503886 rs200185314 T T hsa-miR-4795-3p
21
tgtctATAATAAa
Disrupted
N
-0.014
C hsa-miR-3674
hsa-miR-5701
3
21
tgTCTACAAtaaa
tgtctACAATAAa
Created
Created
N
N
-0.188
-0.071
87503887 rs201306530 A A hsa-miR-4795-3p
21
gtgtctATAATAA
Disrupted
N
-0.014
G hsa-miR-556-3p
hsa-miR-6504-3p
21
10
gtgtctGTAATAA
gtgtCTGTAATAa
Created
Created
N
N
-0.067
-0.257

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