SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015657
Gene Symbol:	ABCA12
Description:	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 12 (ABCA12), transcript variant 2, mRNA.
Gene Location:	chr2(-):215796265-215896810
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.214931561T>C			COSN8766105		SS6003149		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3940-5p	ccaataAACCCAaagttta	0	GUGGGUUG	m6b	Created	no TS	-0.183000	-11.810000
hsa-miR-4507	ccaataAACCCAaagttta	0	CUGGGUUG	m6b	Created	no TS	-0.186000	-10.760000
hsa-miR-629-5p	ccaaTAAACCCAaagttta	0	UGGGUUUA	m8a	Created	no TS	-0.418000	-1.520000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.214932008C>A			COSN7797868		PCSI_0002_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3157-3p	tagagAGGGCAatttaccc	2	CUGCCCUA	m6b	Disrupted	-0.176000	no TS	0.100000
hsa-miR-4290	tagaGAGGGCAatttaccc	4	UGCCCUCC	m7a	Disrupted	-0.175000	no TS	No effect
hsa-miR-4446-5p	tagagAGGGAAATttaccc	6	AUUUCCCU	m8a	Created	-0.191000	-0.284000	No effect
hsa-miR-513a-3p	tagagaggGAAATTTAccc	0	UAAAUUUC	m8a	Created	-0.052000	0.046000	-5.720000
hsa-miR-513c-3p	tagagaggGAAATTTAccc	0	UAAAUUUC	m8a	Created	-0.052000	0.046000	-5.530000
hsa-miR-642a-5p	tagAGAGGGAaatttaccc	6	GUCCCUCU	m7b	(m6c->m7b)	-0.189000	-0.492000	-1.430000
hsa-miR-874	tagagAGGGCAatttaccc	2	CUGCCCUG	m6b	Disrupted	-0.149000	no TS	5.760000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.214932059G>T			COSN6937906		8044719		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3065-3p	catggggacGTGCTGAacc	2	UCAGCACC	m7a	(m7a->m6a)	-0.089000	no TS	7.440000
hsa-miR-545-3p	catggggacTTGCTGAacc	0	UCAGCAAA	m7a	(m6a->m7a)	no TS	-0.035000	-0.200000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
214931901	rs189866805	-	G	hsa-miR-3679-3p hsa-miR-6887-3p	1 1	gggagGGGGGAAt gGGAGGGGggaat	Unknown Unknown	N N	-0.115 -0.186
			A	hsa-miR-1470 hsa-miR-3938 hsa-miR-4667-3p hsa-miR-5193 hsa-miR-642a-5p hsa-miR-6749-3p	1 1 1 1 1 1	gggaGGAGGGAat gggaggAGGGAAT gggAGGAGGGAat ggGAGGAGGgaat gggagGAGGGAAt GGGAGGAgggaat	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	-0.139 -0.019 -0.33 -0.129 -0.103 -0.155

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